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RecruitingLast updated:25 November 2022

This phase I/II trial is evaluating a new type of immunotherapy (CTX110) in patients with B-Cell malignancies (Non-Hodgkin Lymphoma) that have got worse or not responded to prior treatmentA Phase 1/2 Dose Escalation and Cohort Expansion Study of the Safety and Efficacy of Allogeneic CRISPR-Cas9-Engineered T Cells (CTX110) in Subjects With Relapsed or Refractory B-Cell Malignancies

Clinical summary

Summary

This is a dose escalation and expansion trial. Eligible participants will receive CTX110 (a CD19-directed T-cell immunotherapy) by intravenous infusion, followed by lymphodepleting chemotherapy.

Age

People18+

Phase

I/II

More information

Trial Identifiers

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Commercial Sponsor

CRISPR Therapeutics AG

Scientific Title

A Phase 1/2 Dose Escalation and Cohort Expansion Study of the Safety and Efficacy of Allogeneic CRISPR-Cas9-Engineered T Cells (CTX110) in Subjects With Relapsed or Refractory B-Cell Malignancies

Eligibility

Inclusion

  • You have certain types of non-cancer medical conditions.
  • You have been diagnosed with a prior or secondary type of cancer.
  • You have had certain treatments, surgical procedures or drugs.

Exclusion

  • You have had treatment but your cancer has gotten worse or has not responded to the treatment you have been given.
Message

Clinical trials have complex eligibility criteria.

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