Keychain 006 : A Phase 3 Study of Pembrolizumab in Combination With Pemetrexed/Platinum (Carboplatin or Cisplatin) Followed by Pembrolizumab and Maintenance Olaparib vs Maintenance Pemetrexed in the First-Line Treatment of Participants With Metastatic Nonsquamous Non-Small-Cell Lung Cancer

Male or<br/>FemaleGender Male or
Female

RecruitingStatus Recruiting

Systemic<br/>Therapy TrialTypeSystemic
Therapy Trial

ThreePhase Three

18+Age Over 18

Lung<br/>CancersCancer LocationLung
Cancers

Systemic therapy | LungMesothelioma

Trial Overview Read MoreRead more

This phase 3 trial is comparing the effectiveness of using either two targeted therapies (pembrolizumab and olaparib), or one targeted therapy (pembrolizumab) with a chemotherapy (pemetrexed) for the treatment of metastatic Non-Small-Cell Lung Cancer.
 

This trial is treating patients with Non-Small-Cell Lung Cancer.

This is a systemic therapy.

You may be able to join this trial if:

  • You are able to swallow medication by mouth.
  • Your cancer has spread to other parts of the body.

You may be excluded from this trial if:

  • You have a certain disease or psychological condition.
  • You have been diagnosed with a prior or secondary type of cancer.
  • You have had certain treatments, surgical procedures or drugs.

Clinical trials have complex eligibility criteria - talk to your doctor about your interest in this trial.

Clinical Summary Read MoreRead more

Trial Identifiers

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Scientific Title

A Phase 3 Study of Pembrolizumab in Combination With Pemetrexed/Platinum (Carboplatin or Cisplatin) Followed by Pembrolizumab and Maintenance Olaparib vs Maintenance Pemetrexed in the First-Line Treatment of Participants With Metastatic Nonsquamous Non-Small-Cell Lung Cancer

Commercial Sponsor

Merck

Summary

There will be two parts of this trial. The first part is the Induction phase. All patients eligible to participate in this trial will receive intravenous administration of Pembrolizumab, Pemetrexed and a platinum based chemotherapy during the Induction phase. The intravenous infusion will occur over four 21 day cycles on Day 1. Following Induction phase, the Maintenance phase will commence. People eligible to participate in the Maintenance phase will either receive intravenous administration of Pembrolizumab on Day 1 of each 21 day cycle and orally administered Olaparib twice daily, or Pembrolizumab and Pemetrexed both administered through intravenous infusion on Day 1 of each 21 day cycle. Maintenance will continue for up to 31 cycles.

Recruiting Hospitals Read MoreRead more

Monash Health, Medical Oncology
Clayton
Lung Research Study Coordinator
lung.oncresearch@monashhealth.org
0417607146

Trial Overview: General information about a clinical trial. This section provides an overview of who might be able to join this trial and what type of treatment is involved.

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