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RecruitingLast updated: 29 September 2022

LuPARP: This phase I trial is evaluating the combination of an oral therapy (olaparib) and a combination therapy (177Lu-PSMA) in patients with castration resistant prostate cancer that has spread to other parts of the body and progressed on other targeted treatments177Lu-PSMA-617 Therapy and Olaparib in Patients With Metastatic Castration Resistant Prostate Cancer

Clinical summary


To be eligible for this trial, patients must have metastatic castration resistant prostate cancer (mCRPC) that has progressed with a novel AR targeted agent (abiraterone and/or enzalutamide and/or apalutamide) and has not previously been exposed to platinums, PARP inhibitors or 177Lu-PSMA. Patients can have had prior exposure to docetaxel in the chemotherapy naïve setting or castrate setting. Eligible patients will be enrolled in the trial in two stages: a dose escalation and expansion stage. Depending on the stage of enrolment, patients will receive either escalating or fixed 7.4 GBq of 177Lu-PSMA every 6 weeks together with olaparib on days 2-15 of each cycle. A cycle is 42 days long. Patients will receive up to 4 cycles of treatment.


This trial is treating patients with castration resistant prostate cancer.


Urinary System Cancers Urinary System





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Commercial Sponsor

Peter MacCallum Cancer Centre

Scientific Title

177Lu-PSMA-617 Therapy and Olaparib in Patients With Metastatic Castration Resistant Prostate Cancer



  • You are able to swallow medication by mouth.
  • You have had treatment but your cancer has gotten worse or has not responded to the treatment you have been given.
  • Your cancer has spread to other parts of the body.


  • You have certain types of non-cancer medical conditions.
  • You have been diagnosed with a prior or secondary type of cancer.
  • You have had certain treatments, surgical procedures or drugs.
  • You have previously been treated (or are currently being treated) on a clinical trial.

Clinical trials have complex eligibility criteria.

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