PIVOT-10: This phase II trial is testing an experimental immunotherapy (NKTR-214) in combination with another standard type of immunotherapy (Nivolumab) in patients with advanced urothelial cancer that have low PD-L1 expressionA Phase 2, Randomized, Non-Comparative, Open-Label Study of NKTR-214 in Combination With Nivolumab and of Chemotherapy in Cisplatin Ineligible, Locally Advanced or Metastatic Urothelial Cancer Patients With Low PD-L1 Expression

Exclusion

• Patients who have an active, known or suspected autoimmune disease
• Patients must not have received prior IL-2 therapy
• Prior treatment with an anti PD-1, anti PD-L1, or anti cytotoxic T lymphocyte associated protein 4 (anti CTLA-4) antibody, agents that target IL-2 pathway, or any other antibody or drug specifically targeting T-cell co-stimulation or immune checkpoint pathways
• Patients with hypertension must be on a stable antihypertensive regimen for the 14 days prior to Cycle 1 Day 1

Additional protocol-defined inclusion/exclusion criteria applied