KEYLYNK-001 : Study of Chemotherapy With Pembrolizumab (MK-3475) Followed by Maintenance With Olaparib (MK-7339) for the First-Line Treatment of Women With BRCA Non-mutated Advanced Epithelial Ovarian Cancer (EOC)

Female<br/>OnlyGender Female
Only

RecruitingStatus Recruiting

Systemic<br/>Therapy TrialTypeSystemic
Therapy Trial

ThreePhase Three

18+Age Over 18

Female Reproductive<br/>System CancersCancer LocationFemale Reproductive
System Cancers

Systemic therapy | Female reproductive organsFallopian tube,Ovary,Peritoneal

Trial Overview Read MoreRead more

This phase III trial is evaluating the effectiveness and safety of chemotherapy (carboplatin and paclitaxel) in combination with two targeted therapies (Pembrolizumab and Olaparib) to treat women with epithelial ovarian, fallopian tube or primary peritoneal cancer..
 

This trial is treating patients with ovarian, fallopian tube and primary peritoneal cancers.

This is a systemic treatment.

You may be able to join this trial if:

  • You are able to swallow medication by mouth.
  • You have had a certain type of treatment or surgical procedure.

You may be excluded from this trial if:

  • You have a certain disease or psychological condition.
  • You have been diagnosed with a prior or secondary type of cancer.
  • You have had certain treatments, surgical procedures or drugs.
  • You have previously been treated (or are currently being treated) on a clinical trial.

Clinical trials have complex eligibility criteria - talk to your doctor about your interest in this trial.

Clinical Summary Read MoreRead more

Trial Identifiers

Use the hyperlinks, where available to access additional clinical trial information.

Scientific Title

Study of Chemotherapy With Pembrolizumab (MK-3475) Followed by Maintenance With Olaparib (MK-7339) for the First-Line Treatment of Women With BRCA Non-mutated Advanced Epithelial Ovarian Cancer (EOC)

Cooperative Group

European Network for Gynaecological Oncological Trial Groups

Commercial Sponsor

Merck Sharp & Dohme Corp

Summary

Patients eligible to participate in this trial will receive an initial 3-week cycle of carboplatin and paclitaxel administered intravenously. After the initial chemotherapy, patients will receive 5 x 3-week cycles of chemotherapy in combination with either pembrolizumab or a placebo on day one of each 3-week cycle for up to 35 cycles, and olaparib or a placebo administered orally twice per day starting on cycle 7. All participants may also receive Bevacizumab on Day 1 of each 3-week cycle.

Recruiting Hospitals Read MoreRead more

Western Health - Sunshine Hospital
St Albans
Ms Heike Raunow
Heike.Raunow@wh.org.au
03 8395 9167

Trial Overview: General information about a clinical trial. This section provides an overview of who might be able to join this trial and what type of treatment is involved.

Next