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CompletedLast updated: 2 October 2023

ARCUS Breast/Gyne: This phase I trial is testing different chemotherapy and immunotherapy combinations in patients with advanced triple-negative breast cancer or ovarian cancerA Phase 1/1b Study to Evaluate the Safety and Tolerability of Immunotherapy Combinations in Participants With Breast and Gynecologic Malignancies

Clinical summary


This is a dose escalation and expansion trial. The Dose Escalation phase will inform the Dose Expansion dose level for AB928 alone and in combination with IPI-549. Patients enrolled in the Dose Expansion phase will be assigned to received the recommended dose level of AB928 and/or IPI-549 in combination with standard PLD or NIP chemotherapy. Patients will be assigned to an Arm based on their tumour diagnosis.


This trial is treating patients with triple negative breast cancer or ovarian cancer.


Advanced Cancers Advanced





Trial Acronym

ARCUS Breast/Gyne

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Trial Identifiers

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Commercial Sponsor

Arcus Biosciences, Inc.

Scientific Title

A Phase 1/1b Study to Evaluate the Safety and Tolerability of Immunotherapy Combinations in Participants With Breast and Gynecologic Malignancies



  • Your cancer has spread to other parts of the body.


  • You have been diagnosed with a prior or secondary type of cancer.
  • You have certain types of non-cancer medical conditions.
  • You have had certain treatments, surgical procedures or drugs.
  • You have previously been treated (or are currently being treated) on a clinical trial.

Clinical trials have complex eligibility criteria.

Ask your doctor if this trial could be right for you.

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