PRINCE : Phase Ib/II Study of Radionuclide 177Lutetium-PSMA-617 Therapy in Combination With Pembrolizumab for Treatment of Metastatic Castration Resistant Prostate Cancer (mCRPC)

Male<br/>OnlyGender Male
Only

RecruitingStatus Recruiting

Systemic<br/>Therapy TrialTypeSystemic
Therapy Trial

OnePhase One

18+Age Over 18

Prostate<br/>CancersCancer LocationProstate
Cancers

Systemic therapy | Urinary systemProstate

Trial Overview Read MoreRead more

This phase Ib trial is evaluating the effectiveness of radionuclide therapy (177Lutetium-PSMA) in combination with immunotherapy (Pembrolizumab) to treat patients with Metastatic Castration Resistant Prostate Cancer.
 

This trial is treating patients with Prostate cancer.

This is a systemic therapy.

You may be able to join this trial if:

  • You have had a certain type of treatment or surgical procedure.
  • You have had treatment but your cancer has gotten worse or has not responded to the treatment you have been given.
  • Your cancer has spread to other parts of the body.

You may be excluded from this trial if:

  • You have a certain disease or psychological condition.
  • You have had certain treatments, surgical procedures or drugs.

Clinical trials have complex eligibility criteria - talk to your doctor about your interest in this trial.

Clinical Summary Read MoreRead more

Trial Identifiers

Use the hyperlinks, where available to access additional clinical trial information.

Scientific Title

Phase Ib/II Study of Radionuclide 177Lutetium-PSMA-617 Therapy in Combination With Pembrolizumab for Treatment of Metastatic Castration Resistant Prostate Cancer (mCRPC)

Other Non-Commercial Sponsor

Peter MacCallum Cancer Centre

Summary

This phase Ib trial is examining the safety, tolerability and effectiveness of combining radionuclide therapy (177Lu-PSMA) with immunotherapy (Pembrolizumab)for patients with metastatic Castration Resistant Prostate Cancer. Patients eligible for this trial will receive 177Lu-PSMA every 6 weeks for up to 4 cycles and pembrolizumab every 3 weeks for up to 35 cycles.

Recruiting Hospitals Read MoreRead more

PCCTU (Parkville Cancer Clinical Trials Unit) *
Parkville
Ms Marian Lieschke
marian.lieschke@petermac.org
03 8559 7140

Trial Overview: General information about a clinical trial. This section provides an overview of who might be able to join this trial and what type of treatment is involved.

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