This phase III trial is comparing an immunotherapy to standard of care treatment in adults who have been diagnosed with B-cell Non-Hodgkin Lymphoma and have failed prior immunochemotherapy.
This trial is treating patients with B-Cell Non-Hodgkin Lymphoma.
This is a systemic therapy trial.
You may be able to join this trial if:
- You have had treatment but your cancer has gotten worse or has not responded to the treatment you have been given.
You may be excluded from this trial if:
- You have a certain disease or psychological condition.
- You have had certain treatments, surgical procedures or drugs.
Clinical trials have complex eligibility criteria - talk to your doctor about your interest in this trial.
Clinical Summary Read More
Trial Identifiers
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Scientific Title
Tisagenlecleucel Versus Standard of Care in Adult Patients With Relapsed or Refractory Aggressive B-cell Non-Hodgkin Lymphoma: A Randomized, Open Label, Phase III Trial
Commercial Sponsor
Novartis Pharmaceuticals
Summary
Eligible patients will be randomised to receive the investigator's choice of optional platinum-based immunochemotherapy followed by (1) lymphodepleting chemotherapy (containing fludarabine with cyclophosphamide or bendamustine) and a single dose of Tisagenlecleucel OR (2, in responding patients only) high dose chemotherapy and autologous hematopoietic stem cell transplant (HSCT).
Not Recruiting Hospitals Read More