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Closed (no longer recruiting)Last updated:18 July 2021

BELINDA: This phase III trial is comparing an immunotherapy to standard of care treatment in adults who have been diagnosed with B-cell Non-Hodgkin Lymphoma and have failed prior immunochemotherapyTisagenlecleucel Versus Standard of Care in Adult Patients With Relapsed or Refractory Aggressive B-cell Non-Hodgkin Lymphoma: A Randomized, Open Label, Phase III Trial

Clinical summary

Summary

Eligible patients will be randomised to receive the investigator's choice of optional platinum-based immunochemotherapy followed by (1) lymphodepleting chemotherapy (containing fludarabine with cyclophosphamide or bendamustine) and a single dose of Tisagenlecleucel OR (2, in responding patients only) high dose chemotherapy and autologous hematopoietic stem cell transplant (HSCT).

Age

People18+

Phase

III

Trial Acronym

BELINDA

More information

Trial Identifiers

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Commercial Sponsor

Novartis Pharmaceuticals

Scientific Title

Tisagenlecleucel Versus Standard of Care in Adult Patients With Relapsed or Refractory Aggressive B-cell Non-Hodgkin Lymphoma: A Randomized, Open Label, Phase III Trial

Eligibility

Inclusion

  • You have certain types of non-cancer medical conditions.
  • You have had certain treatments, surgical procedures or drugs.

Exclusion

  • You have had treatment but your cancer has gotten worse or has not responded to the treatment you have been given.
Message

Clinical trials have complex eligibility criteria.

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