HI-FIVE: This trial is using different medical imaging techniques to enhance radiotherapy treatment in patients diagnosed with non-small cell lung cancer (NSCLC)High Intensity Functional Image Guided Vmat Lung Evasion

Exclusion

• Participant is not able to tolerate supine position on PET/CT bed for the duration of the PET/CT acquisitions, is not cooperative, or needs continuous nursing (e.g. patient from Intensive Care Unit) or is unable to attend full course of follow up visits
• Pregnancy or Breast-feeding
• If history of a prior extra thoracic invasive malignancy (except non-melanomatous skin cancer) must be free from recurrence for a minimum of 3 years at the time of registration
• Prior radiotherapy to the lungs or mediastinum (a history of prior breast radiotherapy is not an exclusion)
• Prior known history of interstitial lung disease * A history of renal impairment or reaction to iodine contrast is not an exclusion criteria, if a patient has medical comorbidities that exclude the use of iodine contrasts, these exploratory investigations can be omitted.