Trial Identifiers
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Scientific Title
A Phase III, Multicenter, Randomized, Open-Label Study Comparing Atezolizumab (Anti PD-L1 Antibody) in Combination With Adjuvant Anthracycline/Taxane-Based Chemotherapy Versus Chemotherapy Alone in Patients With Operable Triple Negative Breast Cancer
Commercial Sponsor
Hoffmann-La Roche
Summary
Eligible participants will be randomised to receive chemotherapy alone; OR in combination with atezolizumab (IV, 840 mg), every two weeks for 10 doses, followed by atezolizumab maintenance therapy every 3 weeks to complete 1 year of treatment from the first dose. For both Arms, chemotherapy will consist of paclitaxel (IV, 80mg/m^2) every week for 12 weeks, followed by dose-dense doxorubicin and cyclophosphamide or dose-dense epirubicin and cyclophosphamide, every 2 weeks for 4 doses.