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Closed (no longer recruiting)Last updated: 27 March 2023

CUPISCO: This phase II trial is comparing molecular-guided therapy with standard platinum-containing chemotherapy for the treatment of advanced cancers of the unknown primary (CUP)A Phase II, Randomized, Active-Controlled, Multi-Center Study Comparing the Efficacy and Safety of Targeted Therapy or Cancer Immunotherapy Guided by Genomic Profiling Versus Platinum-Based Chemotherapy in Patients With Cancer of Unknown Primary Site Who Have Received Three Cycles of Platinum Doublet Chemotherapy

Clinical summary

Summary

Eligible participants will be assigned to receive either a molecular-guided therapy based on their genomic profile OR a standard chemotherapy (containing Carboplatin or Cisplatin in combination with Gemcitabine or Paclitaxel), which will be the active comparator to the intervention arm of the trial.

Conditions

This trial is treating patients with cancer of the unknown primary (CUP).

Cancer

Cancer of Unknown Primary Cancer of Unknown Primary

Age

People18+

Phase

II

Trial Acronym

CUPISCO

More information

Trial Identifiers

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Commercial Sponsor

Hoffmann-La Roche

Scientific Title

A Phase II, Randomized, Active-Controlled, Multi-Center Study Comparing the Efficacy and Safety of Targeted Therapy or Cancer Immunotherapy Guided by Genomic Profiling Versus Platinum-Based Chemotherapy in Patients With Cancer of Unknown Primary Site Who Have Received Three Cycles of Platinum Doublet Chemotherapy

Eligibility

Exclusion

  • You have certain types of non-cancer medical conditions.
  • You have had certain treatments, surgical procedures or drugs.
Message

Clinical trials have complex eligibility criteria.

Ask your doctor if this trial could be right for you.

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The Victorian Cancer Trials Link is supported by the Victorian Government through the Victorian Cancer Agency.

RAP

Cancer Council Victoria would like to acknowledge the traditional custodians of the land on which we live and work. We would also like to pay respect to the elders past and present and extend that respect to all other Aboriginal people.