AMG397 : A Phase 1 Open-label Study Evaluating the Safety, Tolerability, Pharmacokinetics and Efficacy of AMG 397 in Subjects With Selected Relapsed or Refractory Hematological Malignancies

Male or<br/>FemaleGender Male or
Female

RecruitingStatus Recruiting

Systemic<br/>Therapy TrialTypeSystemic
Therapy Trial

OnePhase One

18+Age Over 18

Blood<br/>CancersCancer LocationBlood
Cancers

Systemic therapy | Blood / Myeloma / LymphomaAcute Myeloid Leukaemia,Leukaemia,Lymphoma,Multiple Myeloma

Trial Overview Read MoreRead more

This phase I trial evaluates effectiveness, safety and tolerability of the targeted therapy (AMG 397) for the treatment of patients with Multiple Myeloma, Non-Hodgkin Lymphoma or Acute Myeloid Leukaemia.
 

This trial is treating patients with Multiple Myeloma, Acute Myeloid Leukaemia and Non-Hodgkin Lymphoma.

This is a systemic therapy.

You may be able to join this trial if:

  • You are able to swallow medication by mouth.
  • You have had treatment but your cancer has gotten worse or has not responded to the treatment you have been given.
  • You have had treatment, but your cancer has come back.

You may be excluded from this trial if:

  • You have had certain treatments, surgical procedures or drugs.

Clinical trials have complex eligibility criteria - talk to your doctor about your interest in this trial.

Clinical Summary Read MoreRead more

Trial Identifiers

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Scientific Title

A Phase 1 Open-label Study Evaluating the Safety, Tolerability, Pharmacokinetics and Efficacy of AMG 397 in Subjects With Selected Relapsed or Refractory Hematological Malignancies

Commercial Sponsor

AMGEN

Summary

This study aims to assess the effectiveness, safety, tolerability and optimal dose regime for the targeted therapy AMG 397 to treat patients with recurrent Multiple Myeloma, Non-Hodgkin Lymphoma or Acute Myeloid Leukaemia. Patients eligible to participate in this trial will receive AMG 397 two consecutive doses per week over a 28 day cycle.

Recruiting Hospitals Read MoreRead more

Alfred Hospital, Malignant Haematology & Stem Cell Transplantation Service
Prahran
Ms Nola Kennedy
n.kennedy@alfred.org.au
03 9076 2217

Trial Overview: General information about a clinical trial. This section provides an overview of who might be able to join this trial and what type of treatment is involved.

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