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A Phase 1/2, Multicenter, Dose-Escalation and Expansion Study of Combination Therapy With Venetoclax, Daratumumab and Dexamethasone (With and Without Bortezomib) in Subjects With Relapsed or Refractory Multiple Myeloma
This is a non-randomised, dose escalation and expansion trial. In this trial, Venetoclax will be administered orally at varying doses, as determined by the dose-escalation phase. Venetoclax will be administered in combination with Daratumumab (16 mg/kg IV), which will be given in accordance with prescribing information. Bortezomib will be administered via 1.3mg/m2 subcutaneous injection and dexamethasone will be administered orally or by IV, as described in the protocol.