ARCS Multi-Tumour : Phase 1b Multi-indication Study of Anetumab Ravtansine (BAY94-9343) in Patients With Mesothelin Expressing Advanced or Recurrent Malignancies

Male or<br/>FemaleGender Male or
Female

RecruitingStatus Recruiting

Systemic<br/>Therapy TrialTypeSystemic
Therapy Trial

OnePhase One

18+Age Over 18

Advanced CancersCancer LocationMulti-Cancer
Trial

Systemic therapy | Breast,Stomach and upper gastrointestinal tractPancreas

Trial Overview Read MoreRead more

This phase I trial is trying to determine the safety and effectiveness of an immunotherapy drug, given alone and as a combination therapy for mesothelin-expressing advanced cancers.
 

This trial is treating multiple types of cancer including breast or pancreatic cancers.

This is a systemic therapy trial.

You may be able to join this trial if:

  • Your cancer has spread to other parts of the body.

You may be excluded from this trial if:

  • You have a certain disease or psychological condition.
  • You have had certain treatments, surgical procedures or drugs.

Clinical trials have complex eligibility criteria - talk to your doctor about your interest in this trial.

Clinical Summary Read MoreRead more

Trial Identifiers

Use the hyperlinks, where available to access additional clinical trial information.

Scientific Title

Phase 1b Multi-indication Study of Anetumab Ravtansine (BAY94-9343) in Patients With Mesothelin Expressing Advanced or Recurrent Malignancies

Commercial Sponsor

Bayer Inc

Summary

This trial is open for recruitment for patients with Breast Cancer (Triple Negative Breast Cancer) and Pancreatic adenocarcinoma. Other cohorts, which are now closed include Non-Small Cell Lung Cancer, Cholangiocarcinoma, Gastric Adenocarcinoma, Thymic carcinoma. Eligible patients will receive anetumab ravtansine every three weeks in monotherapy for most indications. In cholangiocarinoma and adenocarinoma of the pancreas, 3-weekly anetumab ravtansine will be administered in combination with cisplatin or gemcitabine respectively (both administered in a 2 week on / 1 week off schedule). Treatment will continue until disease progression.

Recruiting Hospitals Read MoreRead more

Epworth Hospital
Richmond
Mr Dave McKee
dave.mckee@epworth.org.au
03 9936 8043

Epworth Freemasons, Medical Oncology
East Melbourne
Ms Amberlee Marker
amberlee.marker @epworth.org.au
03 9936 8056

Trial Overview: General information about a clinical trial. This section provides an overview of who might be able to join this trial and what type of treatment is involved.

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