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Biological Medicine for Diffuse Intrinsic Pontine Glioma (DIPG) Eradication
Institut Gustave Roussy
Other Non-Commercial Sponsor
Innovative Therapies For Children with Cancer Consortium
Participants in this study will be allocated to a treatment that specifically targets a biological abnormality identified via a biopsy. The possible treatment groups are as follows; (1)If the tumor overexpresses EGFR without PTEN loss of expression, patients may receive erlotinib or dasatinib allocated by randomization; (2) If the tumor shows loss of PTEN expression without EGFR overexpression, patients may receive everolimus or dasatinib allocated by randomisation; (3) If the tumor shows both EGFR overexpression and loss of PTEN expression, patients may receive erlotinib, everolimus or dasatinib by randomisation; (4) If the tumor shows neither EGFR overexpression nor loss of PTEN expression (a very rare situation in our experience), patients will receive dasatinib; (5) If the biopsy assessment is not contributive, the treatment will be allocated by randomisation between erlotinib, everolimus and dasatinib.