Trial Identifiers
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Scientific Title
A Randomized Phase III Clinical Trial Evaluating Post-Mastectomy Chestwall and Regional Nodal XRT and Post-Lumpectomy Regional Nodal XRT in Patients With Positive Axillary Nodes Before Neoadjuvant Chemotherapy Who Convert to Pathologically Negative Axillary Nodes After Neoadjuvant Chemotherapy
Cooperative Group
Radiation Therapy Oncology Group
Other Non-Commercial Sponsor
NSABP Foundation Inc
Summary
Eligible patients will be randomised to receive whole breast or regional nodal radiation using IMRT or 3D-CRT once daily 5 days a week for 5 weeks. Patients will be grouped according to whether they have previously undergone a mastectomy or lumpectomy procedure. Lumpectomy patients will receive an additional radiation therapy boost to the lumpectomy cavity once daily 5 days a week for 1-1/2 weeks, following the original radiation treatment.