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A Randomized Phase III Clinical Trial Evaluating Post-Mastectomy Chestwall and Regional Nodal XRT and Post-Lumpectomy Regional Nodal XRT in Patients With Positive Axillary Nodes Before Neoadjuvant Chemotherapy Who Convert to Pathologically Negative Axillary Nodes After Neoadjuvant Chemotherapy
Radiation Therapy Oncology Group
Other Non-Commercial Sponsor
NSABP Foundation Inc
Eligible patients will be randomised to receive whole breast or regional nodal radiation using IMRT or 3D-CRT once daily 5 days a week for 5 weeks. Patients will be grouped according to whether they have previously undergone a mastectomy or lumpectomy procedure. Lumpectomy patients will receive an additional radiation therapy boost to the lumpectomy cavity once daily 5 days a week for 1-1/2 weeks, following the original radiation treatment.