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RecruitingLast updated:29 August 2023

RESOLUTE: This study is assessing the benefit of using a type of local ablative therapy (which could include surgery or radiation therapy) on top of standard of care treatment for people with colorectal cancerRandomised Phase II Trial to Evaluate Progression-Free Survival in Integrating Local Ablative Therapy with First-Line Systemic Treatment for Unresectable Oligometastatic Colorectal Cancer

Clinical summary

Summary

Eligible participants will be randomly allocated to either the local ablative therapy (LAT) arm, or the control arm. In the LAT arm, participants will receive metastasis-directed LAT such as radiation therapy or thermal ablation following initial standard first-line systemic treatment. In the control arm, participants will receive continued first-line systemic treatment alone. Those receiving LAT will return to systemic treatment 16 weeks post-randomisation.

Age

People18+

Phase

Not applicable

Trial Acronym

RESOLUTE

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Trial Identifiers

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Scientific Title

Randomised Phase II Trial to Evaluate Progression-Free Survival in Integrating Local Ablative Therapy with First-Line Systemic Treatment for Unresectable Oligometastatic Colorectal Cancer

Eligibility

Inclusion

  • You have certain types of non-cancer medical conditions.
  • You have been diagnosed with a prior or secondary type of cancer.

Exclusion

  • Your cancer has spread to other parts of the body.
Message

Clinical trials have complex eligibility criteria.

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Participating hospitals

This trial is operating as a teletrial at one or more locations. Learn more about teletrials.

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