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RecruitingLast updated: 15 August 2023

ADORE: This phase I/II trial is evaluating the safety and effectiveness of 5 new drugs in combination treatment for people with myelofibrosisA Randomized, Open-label, Phase I/II Open Platform Study Evaluating Safety and Efficacy of Novel Ruxolitinib Combinations in Myelofibrosis Patients

Clinical summary

Summary

Eligible patients will be randomised to receive different combinations of treatment, using some of the following 5 novel compounds: siremadlin, crizanlizumab, sabatolimab, LTT462 or NIS793.

Conditions

This trial is treating patients with myelofibrosis.

Cancer

Blood Cancers Blood

Age

People18+

Phase

I/II

Trial Acronym

ADORE

More information

Trial Identifiers

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Commercial Sponsor

Novartis Pharmaceuticals

Scientific Title

A Randomized, Open-label, Phase I/II Open Platform Study Evaluating Safety and Efficacy of Novel Ruxolitinib Combinations in Myelofibrosis Patients

Eligibility

Inclusion

  • You are able to swallow medication by mouth.
  • You have had a certain type of treatment or surgical procedure.

Exclusion

  • You have had certain treatments, surgical procedures or drugs.
  • You have previously been treated (or are currently being treated) on a clinical trial.
Message

Clinical trials have complex eligibility criteria.

Ask your doctor if this trial could be right for you.

Participating hospitals

Recruiting hospitals

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The Victorian Cancer Trials Link is supported by the Victorian Government through the Victorian Cancer Agency.

RAP

Cancer Council Victoria would like to acknowledge the traditional custodians of the land on which we live and work. We would also like to pay respect to the elders past and present and extend that respect to all other Aboriginal people.