SummaryThis study will be conducted in two parts: dose escalation and dose confirmation. The dose escalation phase will evaluate escalating doses of a new targeted therapy (called PRT2527) as monotherapy, and in combination with another targeted therapy (called zanubrutinib) until the maximum tolerated dose (MTD) has been identified or when the recommended phase 2 dose is determined (RR2D). The dose confirmation phase will evaluation cancer-specific cohorts at the recommended phase 2 dose level (RP2D) to confirm how safe, tolerable and effective that dose is. Eligible participants will be allocated to receive either PRT2527 alone, or in combination with zanubrutinib. PRT2527 will be administered by intravenous infusion (IV) and zanubrutinib will be provided in capsules to take orally once a day.
Treatment TypeRadiotherapy,Systemic therapy (chemotherapy, hormone therapy or immunotherapy)
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A Phase 1 Open-Label, Multi-Center, Safety and Efficacy Study of PRT2527 as Monotherapy and in Combination With Zanubrutinib in Participants With Relapsed/Refractory Hematologic Malignancies