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RecruitingLast updated:28 August 2023

This study is evaluating how safe, tolerable and effective a new type of immunotherapy is in people with advanced cutaneous squamous cell carcinomaA Phase 2 Study Evaluating INCB099280 in Participants With Advanced Squamous Cell Carcinoma

Clinical summary


This study consists of two parts. In Part 1, participants with metastatic cutaneous squamous cell carcinoma (cSCC) or locally advanced cSCC will be randomly allocated into one of three cohorts. Each cohort will receive a different dose level of immunotherapy (INCB099280). In Part 2, the dose level identified as being the safest and most effective in Part 1 will be expanded to enrol additional participants with metastatic cSCC and locally advanced cSCC.





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Trial Identifiers

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Commercial Sponsor

Incyte Corporation

Scientific Title

A Phase 2 Study Evaluating INCB099280 in Participants With Advanced Squamous Cell Carcinoma



  • You have certain types of non-cancer medical conditions.
  • You have been diagnosed with a prior or secondary type of cancer.
  • You have had certain treatments, surgical procedures or drugs.


  • You are able to swallow medication by mouth.
  • Your cancer has not spread to other parts of the body.
  • Your cancer has spread to other parts of the body.

Clinical trials have complex eligibility criteria.

Ask your doctor if this trial could be right for you.

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