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RecruitingLast updated:15 August 2023

DISCERN: This study aims to comprehensively assess the molecular profile of the tumour ecosystem of cutaneous squamous cell carcinoma patients who receive immunotherapy in the neoadjuvant curative setting in order to identify molecular mechanisms facilitating treatment response and resistance and to identify molecular markers for disease monitoringComprehensive and Deep Profiling in Cutaneous Squamous Cell Carcinomas to Unravel Treatment Efficacy in Immunotherapy Treated Patients

Clinical summary


Eligible participants will receive immunotherapy (cemiplimab) at a dose of 250mg intravenously every 3 weeks for up to 12 weeks. This study has primarily a translational research objective with the clinical component conducted as a prospective, single arm open label study.

Treatment Type

Radiotherapy,Systemic therapy (chemotherapy, hormone therapy or immunotherapy)





Trial Acronym


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Trial Identifiers

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Commercial Sponsor

Peter MacCallum Cancer Centre

Scientific Title

Comprehensive and Deep Profiling in Cutaneous Squamous Cell Carcinomas to Unravel Treatment Efficacy in Immunotherapy Treated Patients



  • You have certain types of non-cancer medical conditions.
  • You have been diagnosed with a prior or secondary type of cancer.
  • You have had certain treatments, surgical procedures or drugs.


  • Your cancer has not spread to other parts of the body.

Clinical trials have complex eligibility criteria.

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