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RecruitingLast updated:15 August 2023

KRYSTAL-12: This study is evaluating how effective targeted therapy (called adagrasib) is compared to chemotherapy (called docetaxel) in people with previously treated metastatic non-small cell lung cancer with a KRAS G12C mutationA Randomized Phase 3 Study of MRTX849 Versus Docetaxel in Patients With Previously Treated Non-Small Cell Lung Cancer With KRAS G12C Mutation

Clinical summary

Summary

Eligible participants will be randomly allocated to one of two treatment arms. In Arm 1 (Experimental), participants will receive adagrasib. In Arm 2 (Active Comparator), participants will receive docetaxel.

Treatment Type

Radiotherapy,Systemic therapy (chemotherapy, hormone therapy or immunotherapy)

Age

People18+

Phase

III

Trial Acronym

KRYSTAL-12

More information

Trial Identifiers

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Commercial Sponsor

Mirati Therapeutics Inc.

Scientific Title

A Randomized Phase 3 Study of MRTX849 Versus Docetaxel in Patients With Previously Treated Non-Small Cell Lung Cancer With KRAS G12C Mutation

Eligibility

Inclusion

  • You have certain types of non-cancer medical conditions.
  • You have had certain treatments, surgical procedures or drugs.

Exclusion

  • You have had a certain type of treatment or surgical procedure.
Message

Clinical trials have complex eligibility criteria.

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Participating hospitals

Recruiting hospitals

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