InformationClinical trials have complex eligibility criteria.
Always talk to your clinician about you’re interest in participating in a trial.Learn why

Optimise reading forHealth ProfessionalsPatients

RecruitingLast updated:15 August 2023

This study aims to identify the recommended dose level, and understand the effectiveness, of a new anti-cancer drug when given in addition to immunotherapy (cetrelimab) in people with metastatic castration-resistant prostate cancerA Phase 1b Study of JNJ-78278343, a T-cell Redirecting Agent Targeting Human Kallikrein 2 (KLK2), in Combination With JNJ-63723283 (Cetrelimab) for Metastatic Castration-Resistant Prostate Cancer

Clinical summary

Summary

This study has two parts. In Part 1 (dose escalation), participants will receive the new experimental drug (JNJ-78278343) in combination with immunotherapy (Cetrelimab). The dose of JNJ-78278343 will be escalated sequentially until a recommended phase 2 dose (RP2D) is established. In Part 2 (dose expansion), participants will receive the combination treatment of Cetrelimab JNJ-78278343 at the dose level determined in Part 1.

Treatment Type

Systemic therapy (chemotherapy, hormone therapy or immunotherapy)

Age

People18+

Phase

I

More information

Trial Identifiers

Use the hyperlinks, where available to access additional clinical trial information.

Commercial Sponsor

Janssen Research & Development, LLC

Scientific Title

A Phase 1b Study of JNJ-78278343, a T-cell Redirecting Agent Targeting Human Kallikrein 2 (KLK2), in Combination With JNJ-63723283 (Cetrelimab) for Metastatic Castration-Resistant Prostate Cancer

Eligibility

Inclusion

  • You have certain types of non-cancer medical conditions.
  • You have had certain treatments, surgical procedures or drugs.

Exclusion

  • You have had a certain type of treatment or surgical procedure.
  • Your cancer has spread to other parts of the body.
Message

Clinical trials have complex eligibility criteria.

Ask your doctor if this trial could be right for you.

Participating hospitals

Recruiting hospitals

InformationTell us if you find this trial availability is not accurate.Report inaccuracy

Get Support

Example

Cancer Connect

Speak with someone who has cancer clinical trial experience.

Learn more

Example

Cancer Council’s cancer nurses

If you need cancer information and practical support for yourself, a carer, family or friend, contact Cancer Council’s experienced cancer nurses on 131120.

Learn more

Example

Information for family, friends and carers

When you are considering a cancer clinical trial, it is a good idea to discuss it with your family, friends or carers.

Learn more

CloseReport inaccuracy

Thank you for helping us to increase accuracy of the trial. Our team will validate the information and update the information as soon as possible.

Submitting ... Please wait