SummaryThis study is recruiting people with advanced or metastatic non-small cell lung cancer (NSCLC) with activating Epidermal Growth Factor Receptor (EGFR) or Human Epidermal Growth Factor Receptor 2 (HER2) mutations.
Eligible participants will be assigned into one of two stages: Stage 1 (Dose escalation and Backfill Cohorts) and Stage 2 (Dose Expansion).
In Stage 1 (Dose Escalation and Backfill), participants will receive escalating doses of Furmonertinib (a type of targeted therapy) which will be given as an oral tablet.
In Stage 2 (Dose Expansion), participants will be grouped into cohorts depending on their diagnosis. All participants will receive Furmonertinib as an oral tablet.
Stage 2 Cohort 1 will enrol people with previously treated NSCLC with EGFR Exon 20 Insertion Mutations.
Stage 2 Cohort 2 will enrol people with previously treated NSCLC with HER2 Exon 20 Insertion Mutations.
Stage 2 Cohort 3 will enrol people with previously treated NSCLC with EGFR Activating Mutations who are not eligible for Cohorts 1 and 4.
Stage 2 Cohort 4 will enrol people with either untreated or previously treated EGFR TKI NaÃ¯ve NSCLC with EGFR Uncommon Mutations, excluding EGFR exon 20 insertion mutations.
Treatment TypeSystemic therapy (chemotherapy, hormone therapy or immunotherapy)
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ArriVent BioPharma, Inc.
A Phase 1b Dose Escalation and Dose Expansion Study Evaluating the Safety, Pharmacokinetics, and Antitumor Activity of Furmonertinib in Patients With Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC) With Activating Epidermal Growth Factor Receptor (EGFR) or Human Epidermal Growth Factor Receptor 2 (HER2) Mutations