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RecruitingLast updated:15 August 2023

This study is investigating targeted therapy (bezuclastinib) for the treatment of advanced systemic mastocytosis (AdvSM), including people with Aggressive SM( ASM), SM with associated haematologic neoplasm (SM-AHN), and Mast Cell Leukaemia (MCL)A Phase 2 Open-Label, Multicenter Clinical Study of the Safety, Efficacy, Pharmacokinetic, and Pharmacodynamic Profiles of CGT9486 as a Single Agent in Patients With Advanced Systemic Mastocytosis

Clinical summary

Summary

There are two parts to this study, including Part I (Dose Optimisation), and Part II Expansion. Part II will be separated into two stages. Participants will receive bezuclastinib, which will be given as tablets to be taken orally, continuously in 28-day cycles.

Age

People18+

Phase

II

More information

Trial Identifiers

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Commercial Sponsor

Cogent Biosciences, Inc

Scientific Title

A Phase 2 Open-Label, Multicenter Clinical Study of the Safety, Efficacy, Pharmacokinetic, and Pharmacodynamic Profiles of CGT9486 as a Single Agent in Patients With Advanced Systemic Mastocytosis

Eligibility

Inclusion

  • You have certain types of non-cancer medical conditions.
  • You have been diagnosed with a prior or secondary type of cancer.
  • You have had certain treatments, surgical procedures or drugs.

Exclusion

  • You are able to swallow medication by mouth.
Message

Clinical trials have complex eligibility criteria.

Ask your doctor if this trial could be right for you.

Participating hospitals

Recruiting hospitals

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