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RecruitingLast updated: 15 August 2023

daNIS-3: This trial is assessing different combinations of treatment with standard care for people with metastatic colorectal cancerAn Open-label, Multi-center, ph II Platform Study Evaluating the Efficacy and Safety of NIS793 and Other New Investigational Drug Combinations With SOC Anti-cancer Therapy for the 2L Treatment of Metastatic Colorectal Cancer (mCRC)

Clinical summary

Summary

Eligible patients will be randomised into the control or investigation arm(s) of the study. The control arm will include participants treated with standard of care (SOC) anti-cancer therapy (bevacizumab with mFOLFOX6 or FOLFIRI) for the second line treatment of metastatic colorectal cancer. The choice of the chemotherapy medications (mFOLFOX6 or FOLFIRI) will be determined by the Investigator based on prior exposure to oxaliplatin or irinotecan. Each investigational arm will include a combination of an investigational drug and the SOC anti-cancer therapy.

Conditions

This trial is treating patients with metastatic colorectal cancer.

Cancer

Bowel Cancers Bowel

Age

People18+

Phase

II

Trial Acronym

daNIS-3

More information

Trial Identifiers

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Commercial Sponsor

Novartis Pharmaceuticals

Scientific Title

An Open-label, Multi-center, ph II Platform Study Evaluating the Efficacy and Safety of NIS793 and Other New Investigational Drug Combinations With SOC Anti-cancer Therapy for the 2L Treatment of Metastatic Colorectal Cancer (mCRC)

Eligibility

Inclusion

  • You have had treatment but your cancer has gotten worse or has not responded to the treatment you have been given.
  • Your cancer has spread to other parts of the body.

Exclusion

  • You have certain types of non-cancer medical conditions.
  • You have had certain treatments, surgical procedures or drugs.
Message

Clinical trials have complex eligibility criteria.

Ask your doctor if this trial could be right for you.

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