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Closed (no longer recruiting)Last updated:27 September 2023

CA001-050: This phase II study is seeking to demonstrate that treatment with a new targeted therapy (BMS-986012) in combination with chemotherapy (carboplatin + etoposide) and immunotherapy (nivolumab) is safe, tolerable and more effective than treatment with chemotherapy and immunotherapy alone in people with newly diagnosed, extensive-stage small cell lung cancerA Randomized, Open-label Phase 2 Clinical Trial of BMS-986012 in Combination With Carboplatin, Etoposide, and Nivolumab as First-line Therapy in Extensive-stage Small Cell Lung Cancer

Clinical summary

Summary

Eligible participants will be randomly allocated to one of two experimental arms. In Experimental Arm A, participants will receive BMS-986012 + carboplatin + etoposide + nivolumab. In Experimental Arm B, participants will receive carboplatin + etoposide + nivolumab.

Age

People18+

Phase

II

Trial Acronym

CA001-050

More information

Trial Identifiers

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Commercial Sponsor

Bristol-Myers Squibb (BMS)

Scientific Title

A Randomized, Open-label Phase 2 Clinical Trial of BMS-986012 in Combination With Carboplatin, Etoposide, and Nivolumab as First-line Therapy in Extensive-stage Small Cell Lung Cancer

Eligibility

Inclusion

  • You have certain types of non-cancer medical conditions.
  • You have had certain treatments, surgical procedures or drugs.

Exclusion

  • Your cancer has not spread to other parts of the body.
  • Your cancer has spread to other parts of the body.
Message

Clinical trials have complex eligibility criteria.

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