This phase II study is trying to understand the effect of a combination of two immunotherapies (evorpacept and pembrolizumab), compared to pembrolizumab alone, in people with head and neck squamous cell carcinoma.
This trial is treating patients with head and neck squamous cell carcinoma.
This is a systemic therapy trial.
You may be able to join this trial if:
- You have been diagnosed with cancer, but have not received any treatment.
- You have had treatment, but your cancer has come back.
- Your cancer has spread to other parts of the body.
You may be excluded from this trial if:
- You have a certain disease or psychological condition.
- You have had certain treatments, surgical procedures or drugs.
Clinical trials have complex eligibility criteria - talk to your doctor about your interest in this trial.
Clinical Summary Read More
Use the hyperlinks, where available to access additional clinical trial information.
A Phase 2 Study of Evorpacept (ALX148) in Combination With Pembrolizumab in Patients With Advanced Head and Neck Squamous Cell Carcinoma (ASPEN-03)
ALX Oncology Inc.
Eligible participants will be randomly assigned to either the Experimental Arm or the Active Comparator Arm. In the Experimental Arm, participants will receive evorpacept (45mg/kg) administered via intravenous infusion, as well as pembrolizumab (200mg), also administered via intravenous infusion, every 3 weeks. In the Active Comparator Arm, participants will receive pembrolizumab (200mg) administered via intravenous infusion every 3 weeks.
Recruiting Hospitals Read More