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RecruitingLast updated:15 August 2023

STRASS2: This phase III study is trying to determine whether having chemotherapy before surgery is more effective than surgery alone in people with dedifferentiated liposarcoma and leiomyosarcomaA Randomized Phase III Study of Neoadjuvant Chemotherapy Followed by Surgery Versus Surgery Alone for Patients With High Risk RetroPeritoneal Sarcoma (RPS)

Clinical summary

Summary

Eligible participants will be randomly allocated to either the Standard Arm or the Experimental Arm. In the Standard Arm, participants will receive large en-bloc curative-intent surgery within 4 weeks following randomisation. In the Experimental Arm, participants will receive 3 cycles of neoadjuvant chemotherapy starting within 2 weeks following randomisation. People with liposarcoma will receive ADM (doxorubicin) 75mg/m2 (or the equivalent EpiADM 120mg/m2) + ifosfamide 9g/m3 every 3 weeks. People with leiomyosarcoma will receive ADM 75mg/m2 + DTIC (dacarbazine) 1g/m2 every 3 weeks. Following this, participants in the experimental arm will be re-assessed to determine whether surgery can proceed. If yes, curative-intent surgery will be performed within 3-6 weeks of last cycle of chemotherapy.

Age

People18+

Phase

III

Trial Acronym

STRASS2

More information

Trial Identifiers

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Commercial Sponsor

European Organisation for Research and Trearment of Cancer (EORTC)

Scientific Title

A Randomized Phase III Study of Neoadjuvant Chemotherapy Followed by Surgery Versus Surgery Alone for Patients With High Risk RetroPeritoneal Sarcoma (RPS)

Eligibility

Inclusion

  • You have certain types of non-cancer medical conditions.
  • You have been diagnosed with a prior or secondary type of cancer.
  • You have had certain treatments, surgical procedures or drugs.

Exclusion

  • You have been diagnosed with cancer, but have not received any treatment.
Message

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