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RecruitingLast updated:15 August 2023

EQUATOR: This phase III study is evaluating how safe and effective targeted therapy (itolizumab) is, compared to a placebo, in people with acute graft versus host diseaseA Phase 3, Randomized, Double-Blind, Placebo-Controlled Multicenter Study of Itolizumab in Combination With Corticosteroids for the Initial Treatment of Acute Graft Versus Host Disease

Clinical summary

Summary

Eligible participants will be randomly allocated to either the Experimental Arm or Placebo Comparator Arm. In the Experimental Arm, participants will receive itolizumab administered by intravenous infusion every two weeks for a total of 7 doses. In the Placebo Comparator Arm, participants will receive a Placebo administered intravenous infusion every 2 weeks for a total of 7 doses.

Age

People12+

Phase

III

Trial Acronym

EQUATOR

More information

Trial Identifiers

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Commercial Sponsor

Equillium

Scientific Title

A Phase 3, Randomized, Double-Blind, Placebo-Controlled Multicenter Study of Itolizumab in Combination With Corticosteroids for the Initial Treatment of Acute Graft Versus Host Disease

Eligibility

Inclusion

  • You have certain types of non-cancer medical conditions.
  • You have been diagnosed with a prior or secondary type of cancer.
  • You have had certain treatments, surgical procedures or drugs.

Exclusion

  • You have had a certain type of treatment or surgical procedure.
Message

Clinical trials have complex eligibility criteria.

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Participating hospitals

Recruiting hospitals

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