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A Modular Phase I/II, Open-Label, Multi-Centre Study to Assess the Safety, Tolerability, Pharmacokinetics and Preliminary Efficacy of AZD0466 Monotherapy or in Combination in Patients With Advanced Haematological Malignancies
This study consists of 2 individual modules: Module 1 (AZD0466 monotherapy), and Module 2 (Drug-Drug Interaction study of AZD0466 with voriconazole). In Module 1, AZD0466 monotherapy will include 2 parts- Part A (dose escalation) cohorts and Part B (dose expansion) cohorts. Initiation of Part B will depend on the evaluation of safety, tolerability and pharmacokinetics in Part A. AZD0466 will be administered via intravenous infusion (IV). In Module 2, participants may receive AZD0466 (administered via IV) in combination with or without voriconazole (administered orally).