Clinical trials have complex eligibility criteria.Always talk to your clinician about you’re interest in participating in a trial.Learn why
HP Version - Clinical trials have complex eligibility criteria.Always talk to your clinician about you’re interest in participating in a trial.Learn why
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RecruitingLast updated: 2 February 2024
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This is a non-randomised trial for people with haematological malignancies of chronic lymphocytic leukaemia (CLL)/ small lymphocytic lymphoma (SLL), Richter's transformation, marginal zone lymphoma (MZL), mantle cell lymphoma (MCL), follicular lymphoma (FL), and Waldenström's macroglobulinemia (WM). The trial has two parts: Dose Escalation and Confirmation (Part 1) and Cohort Expansion (Part 2). Following determination of a recommended phase 2 dose (RP2D) in Part 1, the study plans to proceed with Part 2 using 8 disease-specific expansion cohorts (Cohorts A to H). Participants will receive nemtabrutinib orally once daily until progressive disease or discontinuation.
This trial is treating patients with chronic lymphocytic leukaemia/ small lymphocytic lymphoma, Richter's transformation, marginal zone lymphoma, mantle cell lymphoma, follicular lymphoma, and Waldenström's macroglobulinemia.
Haematological
18+
II
Use the hyperlinks, where available to access additional clinical trial information.
Merck
A Phase 2 Study to Evaluate the Efficacy and Safety of MK-1026 in Participants With Hematologic Malignancies
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Part 1 and Part 2 (Cohorts A to C)
Has a confirmed diagnosis of CLL/SLL with
Part 2 (Cohorts D to G)
Has a confirmed diagnosis of and response to previous treatment of one of the following:
Part 2 (Cohort H): confirmed diagnosis of WM; participants who are relapsed or refractory to standard therapies for WM including chemoimmunotherapy and a covalent irreversible BTKi
Clinical trials have complex eligibility criteria.
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