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RecruitingLast updated: 15 August 2023

This phase II trial is evaluating how well combinations of chemotherapy (UH-3 and ICE/Cyclo/Tropo) work in treating children, adolescents and young adults with newly diagnosed stage II-IV diffuse anaplastic Wilm's Tumour (DAWT) or relapsed favourable histology Wilm's Tumour (FHWT)Treatment of Newly Diagnosed Diffuse Anaplastic Wilms Tumors (DAWT) and Relapsed Favorable Histology Wilms Tumors (FHWT)

Clinical summary

Summary

This is a non-randomised, open-label study investigating the effects of different regimens of chemotherapy in people with newly diagnosed stage II-IV diffuse anaplastic Wilm's tumours (DAWT) or relapsed favourable histology Wilm's Tumours (FHWT). Participants will DAWT and standard-risk relapsed FHWT will receive the UH-3 chemotherapy regimen, which includes vincristine, doxorubicin, cyclophosphamide, carboplatin, etoposide, and irinotecan. Participants with high- and very-high risk FHWT will receive the ICE/Cyclo/Tropo chemotherapy regimen, which includes ifosfamide, carboplatin, etoposide, cyclophosphamide, and topotecan. All treatments will be administered intravenously (via IV).

Conditions

This trial is treating patients with Wilm's tumour.

Cancer

Urinary System Cancers Urinary System

Age

People>30

Phase

II

More information

Trial Identifiers

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Commercial Sponsor

National Cancer Institute (NCI), Children's Oncology Group

Scientific Title

Treatment of Newly Diagnosed Diffuse Anaplastic Wilms Tumors (DAWT) and Relapsed Favorable Histology Wilms Tumors (FHWT)

Eligibility

Inclusion

  • You have been diagnosed with cancer, but have not received any treatment.
  • You have had treatment but your cancer has gotten worse or has not responded to the treatment you have been given.
  • You have had treatment, but your cancer has come back.

Exclusion

  • You have certain types of non-cancer medical conditions.
  • You have had certain treatments, surgical procedures or drugs.
Message

Clinical trials have complex eligibility criteria.

Ask your doctor if this trial could be right for you.

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