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Treatment of Newly Diagnosed Diffuse Anaplastic Wilms Tumors (DAWT) and Relapsed Favorable Histology Wilms Tumors (FHWT)
Children's Oncology Group
Other Non-Commercial Sponsor
National Cancer Institute (NCI)
This is a non-randomised, open-label study investigating the effects of different regimens of chemotherapy in people with newly diagnosed stage II-IV diffuse anaplastic Wilm's tumours (DAWT) or relapsed favourable histology Wilm's Tumours (FHWT). Participants will DAWT and standard-risk relapsed FHWT will receive the UH-3 chemotherapy regimen, which includes vincristine, doxorubicin, cyclophosphamide, carboplatin, etoposide, and irinotecan. Participants with high- and very-high risk FHWT will receive the ICE/Cyclo/Tropo chemotherapy regimen, which includes ifosfamide, carboplatin, etoposide, cyclophosphamide, and topotecan. All treatments will be administered intravenously (via IV).