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RecruitingLast updated:15 August 2023

TOTAL17: This phase II/III trial is trying to understand how effective using a combination of cancer treatments (including chemotherapy, targeted therapy and immunotherapy) to target specific genes is when treating children with acute lymphoblastic leukaemia (ALL) and acute lymphoblastic lymphoma (LLy)Total Therapy XVII for Newly Diagnosed Patients With Acute Lymphoblastic Leukemia and Lymphoma

Clinical summary


Participants will be classified into one of three categories (low-, standard-, or high-risk) based on a range of factors including diagnosis. Treatment will consist of three main phases: Remission Induction, Consolidation, and Continuation. There may be other phases included depending on the individual's diagnoses and risk. Some treatments will be administered orally, others will be administered intravenously (IV) or intramuscularly (IM), and others will be administered via subcutaneous injection (SQ).


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Commercial Sponsor

Incyte Corporation, St Jude Children's Research Hospital

Scientific Title

Total Therapy XVII for Newly Diagnosed Patients With Acute Lymphoblastic Leukemia and Lymphoma



  • You are able to swallow medication by mouth.
  • You have been diagnosed with cancer, but have not received any treatment.
  • You have had treatment but your cancer has gotten worse or has not responded to the treatment you have been given.
  • You have had treatment, but your cancer has come back.

Clinical trials have complex eligibility criteria.

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