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RecruitingLast updated:15 August 2023

AREN1921: This phase II trial is evaluating the effects of different combinations of chemotherapy (UH-3 and ICE/Cyclo/Topo) in people with newly diagnosed stage II-IV diffuse anaplastic Wilm's Tumour (DAWT) or favourable histology Wilm's Tumour (FHWT) that has come back (relapsed)Treatment of Newly Diagnosed Diffuse Anaplastic Wilms Tumors (DAWT) and Relapsed Favorable Histology Wilms Tumors (FHWT)

Clinical summary

Summary

This is a non-randomised trial with two experimental arms. Participants with new diagnosed diffuse anaplastic Wilm's Tumour (DAWT) will receive a regimen of UH-3, consisting of vincristine, doxorubicin, cyclophosphamide, carboplatin, etoposide, and irinotecan. Participants with favourable histology Wilm's Tumour (FHWT) that has come back (relapsed) will receive a regimen of ICE/Cyclo/Topo, consisting of ifosfamide, carboplatin, etoposide, cyclophosphamide, and topotecan.

Age

People>30

Phase

II

Trial Acronym

AREN1921

More information

Trial Identifiers

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Commercial Sponsor

National Cancer Institute (NCI), Children's Oncology Group

Scientific Title

Treatment of Newly Diagnosed Diffuse Anaplastic Wilms Tumors (DAWT) and Relapsed Favorable Histology Wilms Tumors (FHWT)

Eligibility

Inclusion

  • You have certain types of non-cancer medical conditions.
  • You have previously been treated (or are currently being treated) on a clinical trial.

Exclusion

  • You have been diagnosed with cancer, but have not received any treatment.
  • You have had treatment, but your cancer has come back.
Message

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