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RecruitingLast updated:15 August 2023

This phase I trial is evaluating how safe and tolerable a new biological therapy (AK127) in combination with another biological therapy (AK104 or cadonilimab) in patients with advanced or metastatic solid cancers (excluding some blood cancers)A Phase 1a/1b, Multicenter, Open-Label, Dose-Escalation and Dose-Expansion Study to Evaluate the Safety, Pharmacokinetics, and Anti-tumour Activity of AK127 in Combination With AK104 in Subjects With Advanced or Metastatic Solid Tumours

Clinical summary

Summary

This is an Early Phase 1a/1b dose-escalation and dose-expansion study with one experimental arm. In the dose escalation phase, participants will receive AK127 using the 3+3+3 model given with a fixed regimen of AK104. Both AK127 and AK104 will be administered via intravenous infusion. The dose expansion phase will open at the discretion of the Sponsor.

Age

People18+

Phase

I

More information

Trial Identifiers

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Commercial Sponsor

Akeso

Scientific Title

A Phase 1a/1b, Multicenter, Open-Label, Dose-Escalation and Dose-Expansion Study to Evaluate the Safety, Pharmacokinetics, and Anti-tumour Activity of AK127 in Combination With AK104 in Subjects With Advanced or Metastatic Solid Tumours

Eligibility

Inclusion

  • You have certain types of non-cancer medical conditions.
  • You have had certain treatments, surgical procedures or drugs.

Exclusion

  • Your cancer has not spread to other parts of the body.
  • Your cancer has spread to other parts of the body.
Message

Clinical trials have complex eligibility criteria.

Ask your doctor if this trial could be right for you.

Participating hospitals

Recruiting hospitals

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