Clinical trials are an important way to improve treatment for people with cancer. While most are continuing during the COVID-19 pandemic, the period of time that clinical trials are available and recruiting may change quickly. If you would like to get involved in a clinical trial, speak to your treatment team or the health service where the clinical trial is being undertaken, to confirm it is open and appropriate for you. For cancer information and support, call Cancer Council's experienced cancer nurses on 13 11 20 Monday to Friday from 9am-5pm.

NCT04502394 : An Open-Label, Multicenter, Phase 1b/2 Study of the Safety and Efficacy of KRT-232 in Combination With Acalabrutinib in Subjects With Relapsed/Refractory Diffuse Large B-cell Lymphoma or Relapsed/Refractory Chronic Lymphocytic Leukemia

Male or<br/>FemaleGender Male or
Female

RecruitingStatus Recruiting

Systemic<br/>Therapy TrialTypeSystemic
Therapy Trial

One/TwoPhase One/Two

18+Age Over 18

Blood<br/>CancersCancer LocationBlood
Cancers

Systemic therapy | Blood / Myeloma / LymphomaChronic Lymphocytic Leukaemia,Diffuse Large Cell Lymphoma,Lymphoma

Trial Overview Read MoreRead more

This phase I/II trial is evaluating the effectiveness of a new targeted therapy (KRT-232) combined with another targeted therapy (acalabrutinib) in people with relapsed or refractory diffuse large B-cell lymphoma and chronic lymphocytic leukaemia.
 

This trial is treating patients with relapsed or refractory diffuse large B-cell lymphoma and chronic lymphocytic leukaemia.

This is a systemic therapy trial.

You may be able to join this trial if:

  • You are able to swallow medication by mouth.
  • You have had treatment but your cancer has gotten worse or has not responded to the treatment you have been given.
  • You have had treatment, but your cancer has come back.

You may be excluded from this trial if:

  • You have had certain treatments, surgical procedures or drugs.

Clinical trials have complex eligibility criteria - talk to your doctor about your interest in this trial.

Clinical Summary Read MoreRead more

Trial Identifiers

Use the hyperlinks, where available to access additional clinical trial information.

Scientific Title

An Open-Label, Multicenter, Phase 1b/2 Study of the Safety and Efficacy of KRT-232 in Combination With Acalabrutinib in Subjects With Relapsed/Refractory Diffuse Large B-cell Lymphoma or Relapsed/Refractory Chronic Lymphocytic Leukemia

Commercial Sponsor

Kartos Therapeutics, Inc.

Summary

This is a non-randomised, open-label trial with two experimental cohorts. Experimental Cohort 1 is made up of participants with relapsed or refractory diffuse large B-cell lymphoma, and Experimental Cohort 2 is made up of relapsed or refractory chronic lymphocytic leukaemia. Both cohorts will receive KRT-232 and Acalabrutinib. KRT-232 will be administered orally, once daily, on days 1-7 in a 28-day cycle. Acalabrutinib will be administered 100mg, twice daily, continuously starting on Day 1 in a 28-day cycle.

Recruiting Hospitals Read MoreRead more

Barwon Health, University Hospital Geelong
Geelong
Clinical Trials Manager
HOTTManager@barwonhealth.org.au
(03) 4215 2758

Trial Overview: General information about a clinical trial. This section provides an overview of who might be able to join this trial and what type of treatment is involved.

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