This Phase Ib/II trial is seeking to determine the recommended dose, and then the safety and effectiveness, of a new targeted therapy (JDQ443) alone, and in combination with other targeted therapies (TNO155 and spartalizumab) in people with advanced solid cancers.
This trial is treating patients with advanced solid cancers.
This is a systemic therapy trial.
You may be able to join this trial if:
- Your cancer has not spread to other parts of the body.
- Your cancer has spread to other parts of the body.
You may be excluded from this trial if:
- You have a certain disease or psychological condition.
Clinical trials have complex eligibility criteria - talk to your doctor about your interest in this trial.
Clinical Summary Read More
Use the hyperlinks, where available to access additional clinical trial information.
A Phase Ib/II Open-label, Multi-center Dose Escalation Study of JDQ443 in Patients With Advanced Solid Tumors Harboring the KRAS G12C Mutation
This is an open-label, non-randomised dose escalation trial with four Experimental Arms for people with advanced solid cancers harbouring the KRAS G12C Mutation. In Experimental Arm A, participants will receive JDQ443 alone. In Experimental Arm B, participants will receive JDQ443 in combination with TNO115. In Experimental Arm C, participants will receive JDQ443 in combination with spartalizumab. In Experimental Arm D, participants will receive JDQ443 in combination with TNO155 and spartalizumab.
Recruiting Hospitals Read More