This Phase I trial is evaluating how safe and tolerable a combination of targeted therapies (Blinatumomab and AMG 404) is in adults with relapsed or refractory B Cell precursor Acute Lymphoblastic Leukaemia.
This trial is treating patients with acute lymphoblastic leukaemia.
This is a systemic therapy trial.
You may be able to join this trial if:
- You have had treatment but your cancer has gotten worse or has not responded to the treatment you have been given.
- You have had treatment, but your cancer has come back.
You may be excluded from this trial if:
- You have a certain disease or psychological condition.
- You have had certain treatments, surgical procedures or drugs.
Clinical trials have complex eligibility criteria - talk to your doctor about your interest in this trial.
Clinical Summary Read More
Trial Identifiers
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Scientific Title
A Phase 1b Open-label Study Investigating the Safety, Tolerability, Pharmacokinetics, and Efficacy of Administration of Blinatumomab in Combination With AMG 404 for the Treatment of Adults With Relapsed or Refractory B Cell Precursor Acute Lymphoblastic Leukemia (ALL)
Commercial Sponsor
AMGEN
Summary
This trial has one experimental arm. All participants will receive Blinatumomab (administered as a continuous intravenous infusion) and AMG 404 (administered as an intravenous infusion). Participants will also be administered Dexamethasone (orally or intravenously) prior to blinatumomab treatment as needed.
Recruiting Hospitals Read More