M20-111: This Phase I trial is evaluating how safe and tolerable a new cancer drug (ABBV-637) is alone, or in combination with chemotherapy (docetaxel) or targeted therapy (osimertinib) in in people with relapsed or refractory solid cancersA Phase 1 First In Human Study Evaluating Safety And Efficacy Of ABBV-637 As Either Monotherapy Or In Combination In Adult Subjects With Relapsed And Refractory Solid Tumors

Summary

This is a non-randomised, sequential assignment trial with two parts. The purpose of this study is to evaluate the safety and efficacy (how well the study drug works against the disease) of ABBV-637 alone or in combination with docetaxel/osimertinib in participants with solid tumours (NSCLC). People with relapsed or refractory solid cancers are eligible for Part 1. To participate in Part 2, participants must have non-small cell lunch cancer (NSCLC). In Part 1, participants with solid tumours will receive intravenous (IV) ABBV-637 in 28-day cycles. In Part 2a and 2b, participants will receive IV ABBV-637 in combination with IV docetaxel in 28-day cycles. In Part 3a and 3b, participants will receive intravenous (IV) ABBV-637 in combination with daily oral tablets of osimertinib in 28 days cycle.

Conditions

This trial is treating patients with solid cancers and non-small cell lung cancer.

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