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RecruitingLast updated:15 August 2023

This Phase I trial is evaluating how safe and tolerable a targeted therapy (cevostamab) is in people with relapsed or refractory multiple myelomoaAn Open-Label, Multicenter, Phase Ib Trial Evaluating the Safety, Pharmacokinetics, and Activity of Cevostamab in Patients With Relapsed or Refractory Multiple Myeloma

Clinical summary

Summary

This trial has one experimental arm with two stages. In Arm A1S (Single-Agent Safety Run-In), participants will be administered cevostamab in 28-day cycles on a modified weekly schedule, up to a total of 13 cycles. Upon completion of Arm A1S, Arm A1E (Single-Agent Expansion) may be opened. Participants will be treated with single-agent cevostamab administered in 28-day cycles on a modified weekly schedule. Tocilizumab will be administered for the treatment of cytokine release syndrome (CRS) when necessary.

Age

People18+

Phase

I

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Trial Identifiers

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Commercial Sponsor

Genentech

Scientific Title

An Open-Label, Multicenter, Phase Ib Trial Evaluating the Safety, Pharmacokinetics, and Activity of Cevostamab in Patients With Relapsed or Refractory Multiple Myeloma

Eligibility

Inclusion

  • You have certain types of non-cancer medical conditions.
  • You have had certain treatments, surgical procedures or drugs.

Exclusion

  • You have been diagnosed with cancer, but have not received any treatment.
  • You have had treatment but your cancer has gotten worse or has not responded to the treatment you have been given.
  • You have had treatment, but your cancer has come back.
Message

Clinical trials have complex eligibility criteria.

Ask your doctor if this trial could be right for you.

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