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A Modular Phase I/IIa, Open-label, Multicentre Study to Assess the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Preliminary Efficacy of Ascending Doses of AZD5305 as Monotherapy and in Combination With Anti-cancer Agents in Patients With Advanced Solid Malignancies
This is a non-randomised trial with 3 experimental arms. Each arm has two parts: Part A is dose escalation, and Part B is an expansion. Participants in Experimental Arm 1 will receive AZD5305 monotherapy (orally). In Experimental Arm 2, participants will receive AZD5305 (orally) in combination with Paclitaxel (intravenously). In Experimental Arm 3, participants will receive AZD5305 (orally) + Carboplatin with or without Paclitaxel (intravenously).