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RecruitingLast updated:15 August 2023

PETRA: This Phase I/II trial is trying to determine how safe, tolerable and effective a targeted cancer drug (AZD5305) is alone, or in combination with chemotherapy (paclitaxel and carboplatin) in people with advanced solid cancersA Modular Phase I/IIa, Open-label, Multicentre Study to Assess the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Preliminary Efficacy of Ascending Doses of AZD5305 as Monotherapy and in Combination With Anti-cancer Agents in Patients With Advanced Solid Malignancies

Clinical summary Eligibilty Participating hospital Support

Clinical summary

Summary

This is a non-randomised trial with 3 experimental arms. Each arm has two parts: Part A is dose escalation, and Part B is an expansion. Participants in Experimental Arm 1 will receive AZD5305 monotherapy (orally). In Experimental Arm 2, participants will receive AZD5305 (orally) in combination with Paclitaxel (intravenously). In Experimental Arm 3, participants will receive AZD5305 (orally) + Carboplatin with or without Paclitaxel (intravenously).

Treatment Type

Radiotherapy

Age

People 18 - 130

Phase

I/II

Trial Acronym

PETRA

More information

Trial Identifiers

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NCT04644068
D9720C00001

Commercial Sponsor

AstraZeneca

Scientific Title

A Modular Phase I/IIa, Open-label, Multicentre Study to Assess the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Preliminary Efficacy of Ascending Doses of AZD5305 as Monotherapy and in Combination With Anti-cancer Agents in Patients With Advanced Solid Malignancies

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Eligibility

Inclusion

You have certain types of non-cancer medical conditions.
You have had certain treatments, surgical procedures or drugs.

Exclusion

You are able to swallow medication by mouth.
You have been diagnosed with cancer, but have not received any treatment.
You have had treatment but your cancer has gotten worse or has not responded to the treatment you have been given.

Clinical trials have complex eligibility criteria.

Ask your doctor if this trial could be right for you.

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