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A Randomized Phase III Trial of Stereotactic Ablative Radiotherapy for the Comprehensive Treatment of 4-10 Oligometastatic Tumors (SABR-COMET 10)
Other Non-Commercial Sponsor
This is a randomised trial with experimental and active comparator arms. In the Experimental Arm, participants will receive Stereotactic Ablative Radiotherapy (SABR) plus standard of care treatment: chemotherapy, immunotherapy, hormones, or observation given at the discretion of the treating oncologist. SABR: total dose of radiation of fractions will depend on the site of disease. Doses are 20 Gy in 1 fraction, 30Gy in 3 fractions (every 2 days), or 35 in 5 fractions (daily). In the Active Comparator Arm, participants will receive standard of care treatment: palliative radiotherapy, chemotherapy, immunotherapy, hormones, or observation, at the discretion of the treating oncologist. Palliative Radiation: Investigators should follow the principles of palliative radiotherapy as per the individual institution in order to alleviate symptoms or prevent complications. If radiotherapy is indicated, recommended doses are 8 Gy in 1 fraction, 20 Gy in 5 fractions, and 30 Gy in 10 fractions.