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St. Jude ELIOT: Phase 1 Evaluation of LY2606368, a Molecularly-Targeted CHK1/2 Inhibitor Therapy, in Combination With Cyclophosphamide or Gemcitabine for Children and Adolescents With Refractory or Recurrent Group 3/Group 4 or SHH Medulloblastoma Brain Tumors
Other Non-Commercial Sponsor
St Jude Children's Research Hospital
Eligible patients will be separated into two experimental groups; Experimental: A will received prexasertib + cyclophosphamide and Experimental: B: prexasertib + gemcitabine. Participants from each group will receive combination treatment given intravenously (IV) for up to a total of 24 months.