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CompletedLast updated: 15 August 2023

Crispy Crème: This phase I trial will begin to understand the safety and effectiveness of a new form of immunotherapy for the treatment of patients with multiple myeloma who have not responded or got worse using previous treatmentA Phase 1 Dose Escalation and Cohort Expansion Study of the Safety and Efficacy of Anti-BCMA Allogeneic CRISPR-Cas9-Engineered T Cells (CTX120) in Subjects With Relapsed or Refractory Multiple Myeloma

Clinical summary

Summary

CTX120 B-cell maturation antigen (BCMA)-directed T-cell immunotherapy comprised of allogeneic T cells genetically modified ex vivo using CRISPR-Cas9 gene editing components, will be administered by intravenous (IV) infusion following treatment with lymphodepleting chemotherapy.

Conditions

This trial is treating patients with multiple myeloma.

Cancer

Blood Cancers Blood

Age

People18+

Phase

I

Trial Acronym

Crispy Crème

More information

Trial Identifiers

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Commercial Sponsor

CRISPR Therapeutics AG

Scientific Title

A Phase 1 Dose Escalation and Cohort Expansion Study of the Safety and Efficacy of Anti-BCMA Allogeneic CRISPR-Cas9-Engineered T Cells (CTX120) in Subjects With Relapsed or Refractory Multiple Myeloma

Eligibility

Exclusion

  • You have certain types of non-cancer medical conditions.
  • You have been diagnosed with a prior or secondary type of cancer.
  • You have had certain treatments, surgical procedures or drugs.
  • You have previously been treated (or are currently being treated) on a clinical trial.
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Clinical trials have complex eligibility criteria.

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