Results

Systemic therapy trial

PRAN-16-25 : A Phase III, Double-Blind, Placebo-Controlled, Multicenter, Randomized Study Of...

This phase III trial is combining two drugs (Pracinostat and Azacitidine) in patients with newly diagnosed Acute Myeloid Leukaemia (AML)

Systemic therapy trial

PALLAS : PALbociclib CoLlaborative Adjuvant Study: A Randomized Phase III Trial of Palbociclib...

This phase III trial is assessing whether the addition of palbociclib to adjuvant endocrine therapy will improve outcomes for people with HR+ or HER2 early stage breast cancer

Systemic therapy trial

JAVELIN GASTRIC 100 : A Phase III Open-label, Multicenter Trial of Maintenance Therapy With Avelumab...

This phase III trial is trying to evaluate the effect of using avelumab, instead of continuing first line chemotherapy, in the treatment of advanced stomach and gastro-oesophageal cancers

Systemic therapy trial

IMpassion130 : A phase III, multicenter, randomised, placebo-controlled study of MPDL3280A (anti-PD-L1...

This phase III trial is assessing the safety of using a new drug (MPDL3280A) in combination with nab-paclitaxel (a chemotherapy drug) for the treatment of people with metastatic breast cancer

Systemic therapy trial

AMP-514 : A Phase 1/2, Open-label Study to Evaluate the Safety and Antitumor Activity of MEDI0680...

This phase I/II trial is assessing the safety of the drug MEDI0680, given alone and in combination with MEDI4736 for patients with advanced cancer

Systemic therapy trial

CheckMate 914 : A Phase 3 Randomized Study Comparing Nivolumab and Ipilimumab Combination vs Placebo in...

This phase III trial is trying to determine whether the combination of two immunotherapy drugs (nivolumab and ipilimumab) is effective in preventing cancer recurrence in patients with renal cell carcinoma, who have had part or all of their kidney removed

Systemic therapy trial

A Randomized, Double-blind, Placebo-controlled, Phase III Study Comparing the Combination...

This phase III trial is evaluating the addition of PDR001 biological therapy to two chemotherapy drugs (Dabrafenib and Trametinib) in patients with previously untreated metastatic BRAF V600 mutant melanoma

Systemic therapy trial

MORPHO : A Multi-center, Randomized, Double-blind, Placebo-controlled Phase III Trial of the FLT3...

This phase III trial is comparing the outcomes of patients with acute myeloid leukaemia (AML) who receive an oral drug (gilteritinib) following stem cell transplantation, with those who receive stem cell transplantation alone

Systemic therapy trial

KEYNOTE-355 : A Randomized, Double-Blind, Phase III Study of Pembrolizumab (MK-3475) Plus Chemotherapy...

This phase III trial is evaluating an immunotherapy drug (Pembrolizumab) in combination with (one of three) chemotherapy drugs, compared to chemotherapy alone, in patients with locally recurrent or metastatic triple negative breast cancer (TNBC)

Systemic therapy trial

monarchE : A Randomized, Open-Label, Phase 3 Study of Abemaciclib Combined With Standard Adjuvant...

This phase III trial is evaluating the addition of an oral drug (Abemaciclib) to standard adjuvant endocrine therapy in patients with high risk, early stage, hormone receptor and node positive, HER 2- breast cancer

Radiotherapy trial

EXPERT : A Randomised Phase III Trial of Adjuvant Radiation Therapy Versus Observation Following...

This phase III trial is examining personalised radiation therapy for low-risk early breast cancer

Systemic therapy trial

AMETHYST : Phase 2, Parallel-Arm Study of MGCD265 in Patients With Locally Advanced or Metastatic...

This phase II trial is testing an oral drug, MGCD265, in patients with locally advanced or metastatic Non-Small Cell (NSC) Lung Cancer that has activating genetic mutations in the MET gene

Systemic therapy trial

BNC101 : A Phase I, Dose Escalation Study of BNC101 (Anti-LGR5 Humanized Monoclonal Antibody) in...

This phase I trial is trying to determine the most appropriate dose of BNC101, an anti-cancer stem cell drug, given alone and in combination with chemotherapy for the treatment of metastatic colorectal cancer

Systemic therapy trial

A Randomized, Double-blind, Phase 2 Trial to Assess Safety and Efficacy of Lenvatinib at...

This phase II trial is evaluating two doses of Lenvatinib (an anti-cancer drug) in combination with Everolimus (an oral drug) in patients who have received prior treatment for Renal Cell Carcinoma

Systemic therapy trial

POSNOC : POsitive Sentinel NOde: Adjuvant Therapy Alone Versus Adjuvant Therapy Plus Clearance or...

This trial is comparing the effect of having adjuvant therapy on its own, or in combination with axillary treatment, in women with metastatic breast cancer

Systemic therapy trial

NABNEC : A phase II study to establish if carboplatin and nab-paclitaxel combination is an...

This phase II trial is evaluating nab-paclitaxel in combination with carboplatin as a first line treatment for gastrointestinal neuroendocrine cancer

Systemic therapy trial

BFAST : A Phase II/III Multicenter Study Evaluating the Efficacy and Safety of Multiple Targeted...

This phase II/III trial is evaluating different targeted therapy and immunotherapy treatments in patients with advanced or metastatic Non-Small Cell (NSC) Lung Cancer

Systemic therapy trial

TAHOE : A Randomized, Open-label, Multicenter, Phase 3 Study of Rovalpituzumab Tesirine Compared...

This phase III trial is comparing two drugs (Rovalpituzumab Tesirine and Topotecan) in patients with advanced or metastatic Small Cell Lung Cancer (SCLC) that has gotten worse following front-line chemotherapy

Multiple treatment types

P_LUNG GP : A Randomised Phase III Trial of High Dose Palliative Radiotherapy (HDPRT) Versus...

This phase III trial is comparing a high dose of palliative radiotherapy alone and in combination with concurrent chemotherapy in patients with metastatic Non-Small Cell (NSC) Lung Cancer

Radiotherapy trial

VERITAS : Vaginal Effects after Radiation Therapy in Anal Cancer Study (Other ID: U1111-1135-9316)

This trial is looking at the effects of vaginal dilator use, following pelvic radiotherapy for anal cancer

Multiple treatment types

ENZARAD : Randomised phase 3 trial of enzalutamide in androgen deprivation therapy with radiation...

This phase III trial is comparing the use of enalutamide, in combination with standard deprivation therapy and radiotherapy, compared to currently available anti-androgen drugs, for patients with localised prostate cancer

Radiotherapy trial

SPARK : Efficacy of Kilovoltage Intrafraction Monitoring (KIM) in Stereotactic Prostate Adaptive...

This phase II trial is evaluating Kilovoltage Infraction Monitoring, a technique used to monitor tumour movement during radiotherapy, in patients with prostate cancer

Multiple treatment types

Local HER-O : A Phase II study of local therapy only (stereotactic radiosurgery and/or surgery) for...

This phase II trial is using radiosurgery and/or surgery to treat brain metastases that have spread from HER 2+ breast cancer

Systemic therapy trial

ALTA-1L : A Phase 3 Multicenter Open-label Study of Brigatinib (AP26113) Versus Crizotinib in...

This phase III trial is comparing two drugs (Brigatinib and Crizotinib) for the treatment of ALK+ Non-Small Cell (NSC) Lung Cancer

Systemic therapy trial

CanStem111P : A Phase III Study of BBI-608 Plus Nab-Paclitaxel With Gemcitabine in Adult Patients With...

This phase III trial is evaluating a new inhibitor drug (BBI-608) with two anti-cancer chemotherapy drugs (nab-paclitaxel and gemcitabine) in patients with metastatic pancreatic cancer

Systemic therapy trial

DYNAMIC : Circulating tumour DNA (ctDNA) analysis informing adjuvant chemotherapy in Stage II Colon...

This study is looking at circulating DNA and how it could inform adjuvant chemotherapy for recurrence-free survival in patient with stage II colon cancer

Multiple treatment types

NIVORAD : A randomised phase 2 trial of nivolumab and stereotactic ablative body radiotherapy in...

This phase II trial is evaluating an immunotherapy (Nivolumab) and stereotactic ablative body radiotherapy in patients with advanced Non-Small Cell (NSC) Lung Cancer whose cancer has gotten worse following chemotherapy treatment

Systemic therapy trial

Lonsurf : An open-label early access phase IIIb study of trifluridine / tipiracil (S 95005/TAS-102)...

This phase III trial is evaluating anti-cancer drugs Trifluridine and Tipiracil in patients who have previously received treatment for metastatic colorectal cancer

Systemic therapy trial

CheckMate 227 : An Open-Label, Randomized Phase 3 Trial of Nivolumab, or Nivolumab Plus Ipilimumab,...

This phase III trial is comparing the effectiveness of Nivolumab in combination with other therapies (Ipilimumab, platinum-doublet chemotherapy and another chemotherapy) for the treatment of advanced Lung Cancer

Systemic therapy trial

A Phase 1 Open-label Study Evaluating the Safety, Tolerability, Pharmacokinetics,...

This phase I trial will be comparing different doses of the drug AMG 701 in patients with Multiple Myeloma

Systemic therapy trial

A Phase IB Open-label, Dose Escalation and Expansion Study to Investigate the Safety,...

This phase I trial is evaluating the drug GSK525762 in combination with androgen deprivation therapy and three other drugs (abiraterone, enzalutamide and prednisone) for the treatment of castrate-resistant prostate cancer (CRPC)

Systemic therapy trial

PEARLS : A Randomized, Phase 3 Trial With Anti-PD-1 Monoclonal Antibody Pembrolizumab (MK-3475)...

This phase III trial is evaluating an immunotherapy drug (Pembrolizumab) as an additional therapy in patients with Non Small Cell (NSC) Lung Cancer following surgery and the completion of a standard adjuvant therapy

Systemic therapy trial

KappaMab : A Phase IIb, open label, sequential cohort study comparing KappaMab alone to KappaMab in...

This phase II trial is evaluating an investigational antibody therapy (KappaMab) in combination with lenalidomide (a chemotherapy drug) and dexamethasone (a steroid) for the treatment of relapsed Multiple Myeloma

Systemic therapy trial

ES414 : A Phase 1 Study of MOR209/ES414 in Patients Wtih Metastatic Castration-Resistant Prostate...

This phase I study is testing the effect of drug MOR209/ES414 in treating patients with metastatic prostate cancer

Systemic therapy trial

A Phase 3, Multi-center, Open-label, Randomized Study of Oral ABL001 Versus Bosutinib in...

This phase III trial is comparing two oral drugs (ABL001 and Bosutinib) for the treatment of Chronic Myelogenous Leukaemia (CML)

Systemic therapy trial

Phase 1 Study to Evaluate Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of...

This phase I trial is evaluating a new drug (AMG 596) in patients with Glioblastoma

Systemic therapy trial

M14-387 : A Phase 1/2 Study of ABT-199 in Combination With Low-Dose Cytarabine in Treatment-Naive...

This phase I/II trial is combining two chemotherapy drugs (venetoclax and cytarabine) in people who haven't received treatment for Acute Myelogenous Leukemia (AML)

Systemic therapy trial

A Phase I/II Dose Escalation and Expansion Study to Investigate the Safety,...

This phase II trial is evaluating two drugs (oral GSK525762 tablets and a Fulvestrant injection) in patients with a breast cancer that has spread to other parts of the body and progressed after a previous treatment

Systemic therapy trial

TRITON2 : A Multicenter, Open-label Phase 2 Study of Rucaparib in Patients With Metastatic...

This phase II trial is evaluating the effect of the anti-cancer drug Rucaparib in patients with metastatic castration-resistant prostate cancer

Systemic therapy trial

CML12 DIRECT : A single arm phase II study to individualize dasatinib dosing based on trough levels and...

This phase II trial is evaluating oral dosing of the drug dasatinib in elderly patients with Chronic Myelogenous Leukaemia (CML)

Systemic therapy trial

CAVEAT : A phase Ib clinical evaluation of Venetoclax in combination with chemotherapy in older...

This phase I trial is evaluating the investigational drug, venetoclax, in combination with chemotherapy for the treatment of Acute Myeloid Leukaemia (AML)

Systemic therapy trial

CLEAR : A Multicenter, Open-label, Randomized, Phase 3 Trial to Compare the Efficacy and Safety...

This phase III trial is comparing three drugs (Lenvatinib in combination with Everolimus or Pembrolizumab) with another targeted drug (Sunitinib) as a first-line treatment for patients with advanced Renal Cell Carcinoma

Systemic therapy trial

ECHELON-2 : A Randomized, Double-blind, Placebo-controlled, Phase 3 Study of Brentuximab Vedotin and...

This phase III trial is comparing Brentuximab Vedotin and CHP chemotherapy, with standard chemotherapy, for the treatment of mature T-Cell Lymphoma

Systemic therapy trial

KEYNOTE-204 : A Phase III, Randomized, Open-label, Clinical Trial to Compare Pembrolizumab With...

This phase III trial is evaluating pembrolizumab (an immunotherapy drug) as a treatment for patients with Hodgkin Lymphoma

Systemic therapy trial

IMpower 132 : A Phase III, Open-Label, Randomized Study of Atezolizumab (MPDL3280A, Anti-Pd-L1...

This phase III trial is comparing Atezolizumab (an immunotherapy drug) in combination with Cisplatin and Pemetrexed (combination chemotherapy), with Cisplatin and Pemetrexed on its own, in patients with stage IV Non-Small Cell (NSC) Lung Cancer

Systemic therapy trial

ADAURA : A Phase III, Double-blind, Randomized, Placebo-controlled Multi-centre, Study to Assess...

This phase III trial is assessing the safety and effictiveness of the drug, AZD9291, in patients with EGFR positive Non-Small Cell (NSC) Lung Cancer

Systemic therapy trial

CT777 : A Phase 3 Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and...

This phase III trial is assessing the addition of andecaliximab to a combination chemotherapy as a first line treatment for people with advanced gastric or gastro-oesophageal cancers

Systemic therapy trial

IRiC : A Phase II Study of Ibrutinib, Rituximab and mini-CHOP (cyclophosphamide, doxorubicin,...

This phase II trial is assessing 6 cycles of chemotherapy in patients with Diffuse Large B-Cell Lymphoma

Systemic therapy trial

Residuum : An Australasian, Phase III, Multicentre, Randomised Trial Comparing Lenalidomide...

This phase III trial is comparing lenalidomide (a type of chemotherapy) consolidation versus no consolidation in patients with Chronic Lymphocytic Leukaemia (CLL)

Systemic therapy trial

ROBUST : Phase 3 Randomized, Double-blind, Placebo Controlled, Multicenter Study to Compare the...

This phase III trial is adding lenalidomide to standard R-CHOP chemotherapy (R2-CHOP) for the treatment of Diffuse Large Cell Lymphoma

Systemic therapy trial

DREAM : A phase 2 trial of durvalumab with first line chemotherapy in mesothelioma with a safety...

This phase II trial is combining a drug (durvalumab) and first line chemotherapy for the treatment of mesothelioma

Systemic therapy trial

OFOCIR : An Australasian, phase II, multicentre, randomised, dose intensification study...

This phase II trial is assessing two oral drugs and one intravenous drug in previously untreated elderly patients with Chronic Lymphocytic Leukaemia (CLL)

Systemic therapy trial

PERSPECTIVE : A Multicenter, Randomized, Double-blind, Placebo-controlled Phase 3 Study of the Bruton's...

This phase III trial is trying to determine the benefit of adding an immunotherapy drug (Ibrutinib) to Rituximab treatment in patients who have been diagnosed with Follicular Lymphoma and not yet received treatment

Systemic therapy trial

ALLG MM18 : Single Arm, Multicentre Study of Carfilzomib in Combination With Thalidomide and...

This phase II trial is combining the drug Carfilzomib with an immunotherapy agent (Thalidomide) and a steroid (Dexamethasone) in patients with relapsed or refractory Multiple Myeloma

Systemic therapy trial

ATTAIN : A Phase 3 Open-Label, Randomized, Multicenter Study of NKTR-102 Versus Treatment of...

This phase III trial is comparing the drug NKTR-102 with a treatment chosen by the doctor in patients who have have been treated for breast cancer that has spread to the brain

Systemic therapy trial

A Phase 1 Trial of SHR3680 in Subjects With Metastatic Castration-Resistant Prostate...

This phase I trial is testing a new oral drug (SHR3680) in patients with metastatic Castration Resistant Prostate Cancer (mCRPC)

Systemic therapy trial

ALT GIST : A Randomised Phase II Trial of Imatinib Alternating With Regorafenib Compared to Imatinib...

This phase II trial is testing imatinib (a type of chemotherapy) alone and in combination with the oral drug regorafenib as a first line treatment for advanced gastrointestinal stromal tumours (GIST)

Systemic therapy trial

ASCOLT : Aspirin for Dukes C and High Risk Dukes B Colorectal Cancers - An International,...

This phase III trial is investigating asprin for Dukes C and high risk Dukes B colorectal cancers

Systemic therapy trial

B-MIND : A Phase 2/3, Randomised, Multicentre Study of MOR208 With Bendamustine Versus Rituximab...

This phase II/III trial is combining bendamustine (a chemotherapy drug) with either MOR208 or rituximab (two types of antibody therapy) for the treatment of Diffuse Large B-cell Lymphoma

Systemic therapy trial

ROBIN : A Randomised, Open Label, Multi-centre, Phase III Study to Investigate the Efficacy of...

This phase III trial is comparing bendamustine (a chemotherapy drug) with another treatment (chosen by the investigator) in patients with Non-Hodgkin Lymphoma

Systemic therapy trial

BGB-3111_001 : A Phase 1b Study to Assess Safety, Tolerability and Antitumor Activity of the Combination...

This phase I trial is evaluating an oral drug (BGB-3111) in combination with another drug (obinutuzumab) for the treatment of B-Cell Non Hodgkin Lymphoma

Systemic therapy trial

BR.31 : A Phase III Prospective Double Blind Placebo Controlled Randomized Study of Adjuvant...

This phase III trial is trying to determine whether it is better to receive a new drug (MEDI4736) after surgery for Lung Cancer, or if it is better to have no further treatment

Systemic therapy trial

Xcovery XALT3 : Phase 3 Randomized Study Comparing X-396 (Ensartinib) to Crizotinib in Anaplastic...

This phase III trial is evaluating the safety and efficacy of X-396 (ensartinib), compared to crizitonib, in patients with ALK+ Non-Small Cell (NSC) lung cancer

Systemic therapy trial

M14-361 : A Phase 1 Dose Escalation and Phase 2 Randomized Double-Blind Study of Veliparib in...

This phase I trial is combining an anti-cancer drug (veliparib) with chemotherapy (carboplatin and etoposide) for the treatment of patients with extensive-stage Small Cell Lung Cancer (SCLC)

Systemic therapy trial

JAVELIN Lung 100 : A Phase III, Open-label, Multicenter Trial of Avelumab (MSB0010718C) Versus...

This phase III trial is comparing the drug, avelumab, with platinum-based doublet chemotherapy in Non-Small Cell (NSC) Lung Cancer patients with PD-L1+ tumours

Systemic therapy trial

LUME-Meso : Double Blind, Randomised, Multicentre, Phase II/III Study of Nintedanib in Combination...

This phase II/III trial is evaluating pemetrexed and cisplatin, alone and in combination with nintedanib, in patients with pleural mesothelioma

Systemic therapy trial

P3BEP : Phase 3 Accelerated BEP Trial: A randomised phase 3 trial of accelerated versus standard...

This phase III trial is tyring to determine whether an accerated two-week treatment of BEP chemotherapy is as effective as receiving the standrard three-week cycle, for patients with metastatic germ cell tumours

Systemic therapy trial

BL12 : A Multicentre Randomized Phase II Trial Comparing Nab-Paclitaxel to Paclitaxel in...

This phase II trial is comparing two types of chemotherapy (Nab-Paclitaxel and Paclitaxel) in patients with advanced urothelial cancer

Systemic therapy trial

GALAHAD : A Phase 2 Efficacy and Safety Study of Niraparib in Men With Metastatic...

This phase II study is assessing the safety and efficacy of niraparib (an oral drug) in men with metastatic castrate resistant prostate cancer and DNA rapair anomolies

Systemic therapy trial

YONDELIS : A Randomized, Open-Label Study Comparing the Combination of YONDELIS and DOXIL/CAELYX...

This phase III trial is assessing two drugs (trabectedin and DOXIL) as third-line chemotherapy for patients with platinum-sensitive, advanced or relapsed Epithelial Ovarian, Primary Peritoneal, or Fallopian Tube Cancer

Systemic therapy trial

S64315 : Phase I, International, Multicentre, Open-label, Non-randomised, Non-comparative Study of...

This phase I trial is evaluating an intravenously administered drug (S64315) for the treatment of Acute Myeloid Leukaemia (AML) or Myelodysplastic Syndrome

Systemic therapy trial

ARCHES : A Multinational, Phase 3, Randomized, Double-blind, Placebo-controlled Efficacy and...

This phase III trial is trying to determine the effect of adding an oral drug (Enzalutamide) to Androgen Deprivation Therapy (ADT) in patients with metastatic Hormone Sensitive Prostate Cancer (mHSPC)

Systemic therapy trial

CT810 : A Study Of Palbociclib In Combination With Letrozole As Treatment Of Post-Menopausal...

This phase IV trial is looking at palbociclib in combination with letrozole, for the treatment hormone receptor positive, HER 2 negative advanced breast cancer in postmenopausal women

Systemic therapy trial

SAUL : An open label, single arm, multicentre, safety study of atezolizumab in locally advanced...

This phase III trial is assessing the safety of atezolizumab (an immunotherapy drug) as second line treatment for patients with advanced cancer of the urinary tract

Systemic therapy trial

KEYNOTE-155 : Phase Ib Trial of Pembrolizumab (MK-3475) in Combination With Dinaciclib (MK-7965) in...

This phase I trial is combining pembrolizumab (an immunotherapy drug) and dinaciclib (an investigational agent) for the treatment of Multiple Myeloma, Diffuse Large Cell Lymphoma and Chronic Lymphocytic Leukaemia

Systemic therapy trial

REACH2 : A Phase III Randomized Open-label Multi-center Study of Ruxolitinib Versus Best Available...

This phase III trial is comparing an oral drug (Ruxolitinib) with the best available therapy in patients with Acute Graft vs. Host Disease

Systemic therapy trial

BCG+MMC : Adding mitomycin C to Bacillus of Calmette-Guerin (BCG) as adjuvant intravesical therapy...

This phase III trial is looking at the effect of adding mitomycin C (a chemotherapy drug) to standard treatment, in patients with invasive bladder cancer

Systemic therapy trial

1stFLOR : First-line Treatment for Grade 1-3A Follicular Lymphoma Using Opdivo (Nivolumab) Plus...

This phase I trial is trying to determine whether it is safe to give the drug Nivolumab before and in combination with the drug Rituximab, in patients who have previously untreated

Systemic therapy trial

CheckMate 908 : Phase Ib /II Clinical Trial of Nivolumab Monotherapy and Nivolumab in Combination With...

This phase I/II trial is evaluating two biological therapies (Nivolumab alone and in combination with Ipilimumab) in children and adolescents that have been diagnosed with advanced Central Nervous System (CNS) cancers

Systemic therapy trial

ALLG MM17 : A multicentre single arm study of carfilzomib-thalidomide-dexamethasone (CarTD) for newly...

This phase II trial is evaluating carfilzomib, thalidomide and dexamethasone (a steroid) for the treatment of newly diagnosed Multiple Myeloma

Systemic therapy trial

Dublin 3 : Randomized Blinded Phase III Assessment of Second or Third-Line Chemotherapy With...

This phase III trial is comparing outcomes for patients with Non-Small Cell (NSC) Lung Cancer, who are receiving second- or third- line chemotherapy with docetaxel alone and in combination with plinabulin, for advanced stage or metastatic disease

Systemic therapy trial

OSCILLATE : Phase 2 trial to determine the efficacy, safety, and feasibility of alternating...

This phase II trial is alternating the use of two oral drugs (Osimertinib and Gefitinib) in patients with advanced EGFR-T790M positive Non-Small Cell (NSC) Lung Cancer

Systemic therapy trial

A Phase 2, Open-label, 2-arm, Response Rate Study Of Talazoparib In Men With Dna Repair...

This phase II trial is evaluating an oral drug (Talazoparib) in men who have previously received treatment for metastatic Castration-Resistant Prostate Cancer (CRPC)

Systemic therapy trial

A Multi-Center, Open Label Study to Assess the Safety, Steady-State Pharmacokinetics and...

This phase I trial is evaluating an oral drug (IMG-7289) in patients with Myelofibrosis

Systemic therapy trial

SYMPATICO : Phase 3 Study of Ibrutinib in Combination With Venetoclax in Subjects With Mantle Cell...

This phase III trial is combining two oral drugs (Ibrutinib and Venetoclax) for the treatment of Mantle Cell Lymphoma

Systemic therapy trial

HER2CLIMB : Phase 2 Randomized, Double-Blinded, Controlled Study of Tucatinib vs Placebo in...

This phase II trial is evaluating the addition of an oral drug (Tucatinib) to treatment with Capecitabine and Trastuzumab in patients with an advanced HER 2+ Breast Cancer that has spread to other parts of the body

Multiple treatment types

KEYNOTE-412 : A Randomized Phase III Study of Pembrolizumab Given Concomitantly With Chemoradiation and...

This phase III trial is trying to determine the effect of adding an immunotherapy drug (Pembrolizumab) to chemoradiation (CRT) concomitantly and as maintenance therapy in patients with locally advanced Head and Neck Squamous Cell Carcinoma (HNSCC)

Systemic therapy trial

FRACTION-Lung : A Phase 2, Fast Real Time Assessment of Combination Therapies in Immuno-Oncology Study in...

This phase II trial is assessing four combination immunotherapies for the treatment of advanced Non-Small Cell (NSC) Lung Cancer

Systemic therapy trial

BEACON : A Multicenter, Randomized, Open-label, 3-Arm Phase 3 Study of Encorafenib + Cetuximab...

This phase III trial is comparing three orally administered chemotherapy drugs (encorafenib, binimetinib, cetuximab) with another treatment, as chosen by the investigator, for the treatment of metastatic colorectal cancer

Systemic therapy trial

PRofound : A Phase III, Open Label, Randomized Study to Assess the Efficacy and Safety of Olaparib...

This phase III trial is evaluating the safety and efficacy olaparib, versus enzalutamide or abiraterone, in patients with metastatic prostate cancer who have failed prior treatment

Systemic therapy trial

A Phase Ib, Open-label, Multicenter Study of Oral LXH254 in Combination With Oral LTT462...

This phase I trial is comparing two oral drugs (LXH254 and LTT462) in patients with metastatic (KRAS or BRAF) Non-Small Cell (NSC) Lung Cancer

Systemic therapy trial

BLIN : A Phase 2/3 Multi-center Study to Evaluate the Safety and Efficacy of Blinatumomab in...

This phase II/III trial is evaluating a drug (Blinatumomab) for the treatment of relapsed or refractory B-Cell Non-Hodgkin Lymphoma

Systemic therapy trial

A Phase IB Combination Study of Rucaparib (CO-338) and Atezolizumab (MPDL3280A) in...

This phase I trial is combining two anti-cancer drugs (Rucaparib and Atezolizumab) in patients with advanced cancers of the female reproductive system, ovarian cancer in particular

Systemic therapy trial

CT869 : A Multinational, Phase 3, Randomized, Double-blind, Placebo-controlled Efficacy and...

This phase III trial is assessing the effect of adding enzalutamide to androgen deprivation therapy (ADT) in patients with metastatic, hormone sensitive prostate cancer

Multiple treatment types

SIRCCA : Prospective, Multicenter, Randomized, Controlled Study Evaluating SIR-Spheres Y-90 Resin...

This phase III trial is evaluating the benefit of adding radiotherapy (SIRT) to systemic chemotherapy (CIS-GEM) as a first line treatment in patients with Intrahepatic Cholangiocarcinoma (a type of liver cancer)

Multiple treatment types

COMPETE : A Prospective, Randomised, Controlled, Open-label, Multicentre Phase III Study to...

This phase III trial is comparing two molecular therapies in patients with neuroendocrine tumours of stomach, intestinal or pancreatic origin

Systemic therapy trial

PHAEDRA : A Phase II trial of durvalumab (Medi 4736) in advanced endometrial cancer A multi-centre...

This phase II trial is evaluating an immunotherapy drug (Durvalumab) for the treatment of advanced Endometrial Cancer

Systemic therapy trial

CanStem303C : A Phase III Study of BBI-608 in Combination With 5-Fluorouracil, Leucovorin, Irinotecan...

This phase III trial is testing a drug called BBI-608 in combination with other drugs, for patients with previously treated metastatic colorectal cancer (CRC)

Systemic therapy trial

ARASENS : A Randomized, Double-blind, Placebo Controlled Phase III Study of ODM-201 Versus Placebo...

This phase III trial is evaluating the addition of an oral drug (ODM-201) to standard androgen deprivation therapy and docetaxel (a steroid) in patients with hormone sensitive prostate cancer that has spread to other parts of the body

Systemic therapy trial

Inharmony : A Phase IB/II Study Evaluating the Safety and Efficacy of Atezolizumab in Combination...

This phase I/II trial is combining four drugs with standard CHOP chemotherapy for the treatment of Follicular Lymphoma and Diffuse Large Cell Lymphoma

Systemic therapy trial

Phase I Open Label, Multi-center Study to Characterize the Safety, Tolerability and...

This phase I trial is assessing a new drug (MIK665) that will be given intravenously in patients with advanced Lymphoma or Multiple Myeloma

Multiple treatment types

JAVELIN HEAD AND NECK 100 : A Randomized Double-blind Phase 3 Study Of Avelumab In Combination With Standard Of Care...

This phase III trial is evaluating the addition of an immunotherapy drug (Avelumab) to standard chemoradiation as a first line treatment for locally advanced cancers of the head and neck

Systemic therapy trial

CANDOR : A Randomized, Open-label, Phase 3 Study Comparing Carfilzomib, Dexamethasone, and...

This phase III trial is comparing Carfilzomib (an anti-cancer drug) and dexamethasone (a steroid) with and without Daratumumab in patients with relapsed Multiple Myeloma

Systemic therapy trial

Eliminate : Randomised phase II trial of neoadjuvant chemotherapy +/- concurrent aromatase inhibitor...

This phase II trial is evaluating the effectiveness of standard neoadjuvant chemotherapy alone and in combination with an aromatase inhibitor (a drug used in post menopausal women) in the treatment of oestrogen receptor positive breast cancer

Systemic therapy trial

AvR-CHOP : Feasibility Study of Induction and Maintenance Avelumab Plus R-CHOP in Patients With...

This phase I trial is assessing induction and maintenance therapy (with Avelumab and R-CHOP chemotherapy) in patients with Diffuse Large B Cell Lymphoma (DLBCL)

Systemic therapy trial

CAVATAK : A phase I/II open-label trial of intravenous CAVATAKTM in combination with Pembrolizumab...

This phase I trial is combining a biological therapy (CAVATAK/CVA21) and an immunotherapy (Pembrolizumab) for the treatment of advanced Non-Small Cell (NSC) Lung Cancer

Systemic therapy trial

INTELLANCE 2 : ABT-414 Alone or ABT-414 Plus Temozolomide vs. Lomustine or Temozolomide for Recurrent...

This phase II trial is evaluating ABT414 alone and in combination with chemotherapy for patients with recurrent glioblastoma

Systemic therapy trial

AOST1421 : A Phase 2 Study of Human-Mouse Chimeric Anti-Disialoganglioside Monoclonal Antibody...

This phase II trial is combining two biological therapies (Dinutuximab and Sagramostim) for the treatment of recurrent Osteosarcoma

Systemic therapy trial

ALLG MM20 : A Multicentre Phase 3 Trial Comparing...

This phase III trial is combining elotuzumab with three other drugs (cyclophosphamide, thalidomide and dexamethasone ) for the treatment of Multiple Myeloma

Systemic therapy trial

SHERLOC : A Phase 2 Study of MM-121 in Combination With Docetaxel or Pemetrexed Versus Docetaxel or...

This phase II trial is trying to determine whether adding a drug (MM-121) to treatment with Docetaxel or Pemetrexed is more effective than using either drug, alone, in patients with heregulin-positive Non-Small Cell (NSC) Lung Cancer

Systemic therapy trial

KEYNOTE-022 : A Phase I/II Study to Assess the Safety and Efficacy of MK-3475 in Combination With...

This phase I/II trial is evaluating the combination of an immunotherapy drug (Pembrolizumab) and two chemotherapy drugs (Dabrafenib and Trametinib) for the treatment of advanced Melanoma

Systemic therapy trial

PCYC-1142-CA : Phase 2 Study of the Combination of Ibrutinib Plus Venetoclax in Subjects With...

This phase II trial is combining a targetted therapy (ibrutinib) with a chemotherapy drug (venetoclax) for the treatment of Chronic Lymphocytic Leukaemia and Small Lymphocytic Leukaemia

Systemic therapy trial

KEYNOTE-522 : A Phase III, Randomized, Double-blind Study to Evaluate Pembrolizumab Plus Chemotherapy...

This phase III trial is evaluating pembrolizumab and chemotherapy alone and in combination, as both an adjuvant and neoadjuvant therapy for Triple Negative Breast Cancer

Systemic therapy trial

METRIC : A Randomized Multicenter Pivotal Study of CDX-011 (CR011-vcMMAE)in Patients With...

This phase II trial will determine whether CDX-011 is an effective treatment for people with triple negative breast cancer

Systemic therapy trial

CITADEL-202 : A Phase 2, Multicenter, International, Open-Label, Safety and Efficacy Study of...

This phase II trial is testing an investigational drug (INCB050465) in patients with Diffuse Large B-Cell Lymphoma that has gotten worse or is not responsive to treatment

Systemic therapy trial

IPATential150 : A Phase III, Randomized, Double-Blind, Placebo-Controlled, Multicenter Trial Testing...

This phase III trial is trying to determine the effect of adding an investigational drug (Ipatasertib) to treatment with two other drugs (Abiraterone and Prednisone/Prednisolone) in patients with metastatic Castration-Resistant Prostate Cancer (mCRPC)

Radiotherapy trial

FASTRACK II : A Mulicentre Phase II clinical trial of STereotactic Ablative Body Radiotherapy for...

This phase II trial is trying to determine the effectiveness of using focal ablative stereotactic radiosurgery (targeted radiotherapy) for the treatment of primary kidney cancer

Systemic therapy trial

GOSSAMER ASTELLAS : A Phase 3 Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial of the FLT3...

This phase III trial is assessing the relapse-free survival of patients who are in complete first remission for Acute Myeliod Leukaemia (AML) and who are randomised to receive gilteritinib after they have completed two years of induction chemotherapy

Systemic therapy trial

MASTERKEY-265 : A Phase 1b/3, Multicenter, Trial of Talimogene Laherparepvec in Combination With...

This phase III trial is evaluating talimogene laherparevec and pembrolizumab for the treatment of late stage Melanoma

Systemic therapy trial

ACE-CL-309 : A Randomized, Multicenter, Open-Label, Phase 3 Study of Acalabrutinib (ACP-196) Versus...

This phase III trial is evaluating acalabrutinib and rituximab (two anti-cancer drugs), given in combination with idelalisib or bendamustine (chemotherapy), for the treatment of Chronic Lymphocytic Leukaemia (CLL)

Systemic therapy trial

MIRROS : A Multicenter, Double-Blind, Randomized, Placebo-Controlled, Phase III Study of...

This phase III trial evaluating a drug (cytarabine) alone and in combination with a chemotherapy (idasanutlin) for the treatment of Acute Myeloid Leukaemia (AML)

Systemic therapy trial

BGB-3111-302 : A Phase 3, Randomized, Open-Label, Multicenter Study Comparing the Efficacy and Safety of...

This phase III trial is comparing two drugs (BGB-3111 and ibrutinib) in the treatment of Waldenström's Macroglobulinemia (a type of Non Hodgkin Lymphoma)

Systemic therapy trial

ROAR : A Phase Ib trial of oral azacitidine in combination with lenalidomide and dexamethasone...

This phase I trial is combining the oral drug azacitidine, with lenalidomide (a chemotherapy drug) and dexamethasone (a steroid) for the treatment of Multpile Myeloma

Systemic therapy trial

PonAZA : A phase Ib/II clinical evaluation of Ponatinib in combination with 5-azacytidine in...

This phase I/II trial is combining an oral drug (ponatinib) with 5- azacitidine for the treatment of Acute Myeloid Leukaemia (AML)

Multiple treatment types

VERTU : A Randomised Phase II study of veliparib and radiotherapy with adjuvant temozolomide and...

This phase II trial is evaluating the effectiveness of an anti-cancer drug (veliparib), radiotherapy and adjuvant (temozolomide) chemotherapy in patients with newly diagnosed Glioblastoma (GBM)

Multiple treatment types

TOP GEAR : A randomised phase II/III trial of preoperative chemoradiotherapy versus preoperative...

This phase II/III trial is comparing preoperative chemradiotherapy with preoperative chemotherapy for patients with resectable gastric cancer

Systemic therapy trial

CT811 : A Phase 3 Placebo-Controlled Study of Carboplatin/Paclitaxel With or Without Concurrent...

This phase III trial is evaluating the use of an anti-cancer drug (veliparib) in women with previously untreated, stage III or IV high-grade serous Epithelial Ovarian, Fallopian Tube, or Primary Peritoneal Cancer

Systemic therapy trial

MDS-AZA-003 : A Phase 3, Multicenter, Randomized, Double-blind Study to Compare the Efficacy and Safety...

This phase III trial is evaluating an oral drug (azacitidine) and best supportive care for the treatment of Myelodysplastic Syndrome

Systemic therapy trial

IntReALL SR 2010 : International Study for Treatment of Standard Risk Childhood Relapsed ALL 2010 A...

This phase III trial is evaluating treatment options for children and adolescents with standard risk of first relapsed Acute Lymphoblastic Leukemia (ALL)

Systemic therapy trial

LCH-IV : International Collaborative Treatment Protocol for Children and Adolescents With...

This phase II/III trial is looking at different treatment protocols for children and adolescents with Langerhans Cell Histiocytosis

Systemic therapy trial

EURONET-PHL-C2 : Second International Inter-Group Study for Classical Hodgkin Lymphoma in Children and...

This phase III trial is evaluating chemotherapy intensification in Hodgkin Lymphoma patients who receive less radiotherapy

Systemic therapy trial

AALL1231 : A Phase III Randomized Trial Investigating Bortezomib (NSC# 681239) on a Modified...

This phase III trial is comparing how well combination chemotherapy works, when given with bortezomib (another chemotherapy drug), for the treatment of newly diagnosed T-cell Acute Lymphoblastic Leukemia (ALL) and T-Cell Lymphoblastic Lymphoma

Systemic therapy trial

PEARL : A Phase III Randomized, Open-Label, Multi-Center, Global Study of Durvalumab Versus...

This phase III trial is evaluating the safety of an immunotherapy drug (Durvalumab) and platinum based SoC chemotherapy as a first line treatment for patients with Non-Small Cell (NSC) Lung Cancer

Systemic therapy trial

feMMe : A Phase II Randomised Clinical Trial of Mirena ± Metformin ± Weight Loss Intervention in...

This phase II trial is trying to determine whether the use of mirena, metformin or a weight loss intervention is effective in the treatment of early-stage endometrial cancer

Systemic therapy trial

Javelin DLBCL : Phase 1b/Phase 3 Multicenter Study Of Avelumab (msb0010718c) In Combination Regimens That...

This phase III trial is evaluating three Avelumab (immunotherapy)-based combination regimens for the treatment of Diffuse Large B-Cell Lymphoma (DLBCL)

Systemic therapy trial

TACTI-mel : A Multicentre, Open Label, Dose Escalation, Phase 1 Study in Patients With Unresectable...

This phase I trial is trying to determine the recommended dose of a new drug (IMP321) when given in combination with an immunotherapy agent (pembrolizumab) for people with metastatic melanoma

Systemic therapy trial

IMmotion010 : A Phase III, Multicenter, Randomized, Placebo-Controlled, Double-Blind Study of...

This phase III trial is assessing atezolizumab (an immunotherapy) as an adjuvant therapy in patients whose renal cell carcinoma is at high risk of recurrence following surgery

Systemic therapy trial

CheckMate 384 : A Dose Frequency Optimization, Phase IIIB/IV Trial of Nivolumab 240 mg Every 2 Weeks vs...

This phase III trial is trying to determine the most effective dose of nivolumab to use in the treatment of advanced Non Small Cell Lung Cancer (NSCLC)

Systemic therapy trial

INTEGRATE II : A Randomised Phase III Double-Blind Placebo-Controlled Study of Regorafenib in Refractory...

This phase III trial is testing the oral drug, regorafenib, for the treatment of refractory and advanced gastro-oesophageal cancers

Systemic therapy trial

PHOCUS : A Phase 3 Randomized, Open-Label Study Comparing Pexa Vec (Vaccinia GM CSF / Thymidine...

This phase III trial is evaluating sorafenib, alone and in combination with immunotherapy treatment, in patients with hepatocellular (liver) cancer

Systemic therapy trial

CheckMate 915 : A Phase 3, Randomized Study of Adjuvant Immunotherapy With Nivolumab Combined With...

This phase III trial is evaluating two investigational immunotherapies (nivolumab and ipilimumab) alone and in combination for the treatment of late stage Melanoma

Systemic therapy trial

IMvigor130 : A Phase III, Multicenter, Randomized, Placebo-Controlled Study of Atezolizumab...

This phase III trial is evaluating atezolizumab and chemotherapy for patients with previously untreated, advanced urothelial cancer

Systemic therapy trial

Harmony : A Phase Ib/II Study Evaluating the Safety and Efficacy of Obinutuzumab in Combination...

This phase I/II trial is combining two investigational agents (obinutuzumab and rituximab) with two drugs (polatuzumab vedotin and venetoclax) in the treatment of Follicular Lymphoma and Diffuse Large Cell Lymphoma

Systemic therapy trial

B1641001 : A Phase 1 Study Of PF-05082566 As A Single Agent In Patients With Advanced Cancer, And In...

This phase I trial is evaluating PF-05082566 (a monoclonal antibody) alone and in combination with rituximab for the treatment of Non-Hodgkin Lymphoma (NHL)

Systemic therapy trial

KEYNOTE-181 : A Phase III Randomized Open-label Study of Single Agent Pembrolizumab vs Physicians'...

This phase III trial is comparing pembrolizumab (an immunotherapy agent) with standard therapy for patients with advanced oesophageal and gastro-oesophageal junction cancers that have gotten worse after first line treatment

Systemic therapy trial

IMbassador250 : A Phase III, Multicenter, Randomized Study of Atezolizumab (Anti-PD-L1 Antibody) in...

This phase III trial will test enzalutamide alone and in combination with an anti-PD-L1 antibody (atezolizumab) for the treatment of metastatic, castration-resistant prostate cancer that has failed prior therapy

Systemic therapy trial

Met Pancreatic : Randomized Study of AM0010 in Combination With FOLFOX Compared to FOLFOX Alone as...

This phase III trial is comparing the effectiveness of FOLFOX (drug) alone and in combination with AM0010 (a biologic therapy) for the treatment of metastatic pancreatic cancer

Radiotherapy trial

FSRT : Can reduced dose radiotherapy delivered in standard fractionation improve the therapeutic...

This phase 0 trial is trying to determine the effect of adding radiotherapy to stereotactic treatment for patients with choroidal melanoma

Multiple treatment types

PanCO : An Open Label, Single Arm Pilot Study of OncoSil™, Administered to Study Participants...

This pilot study will evaluate the radiological implant (OncoSil) in combination with standard chemotherapy, for the treatment of locally advanced pancreatic cancer

Systemic therapy trial

FRACTION-RCC : A Phase 2, Real-time Assessment of Combination Therapies in Immuno-Oncology Study in...

This phase II trial is evaluating different combinations of therapies in patients with advanced renal cell carcinoma

Systemic therapy trial

APROC : A phase1b/2 Study Evaluating the Efficacy of APR-246, a First-in-class Agent Targeting...

This phase Ib/II trial is trying to determine whether the drug APR-246 and two chemotherapy drugs (5-FU and cisplatin) are safe and effective in the treatment of platinum resistant oesophageal cancer

Systemic therapy trial

CT883 : A Multistage, Phase II Study Evaluating the Safety and Efficacy of Cobimetinib Plus...

This phase II trial is evaluating Cobimetinib (a chemotherapy agent), in combination with three drugs (Paclitaxel, Atezolizumab and Nab-Paclitaxel), as a first line treatment for Triple Negative Breast Cancer that has spread to other parts of the body

Systemic therapy trial

CT882 : A Phase 3 Randomized, Open-label, Multicenter Study Comparing Isatuximab (SAR650984) in...

This phase III trial is trying to demonstrate the benefit of adding isatuximab to pomalidomide and dexamethasone treatment in patients with Multiple Myeloma

Systemic therapy trial

OZM-054 : A Phase II, Randomized, Multi-center Study of Cabazitaxel Versus Abiraterone or...

This phase II trial is comparing Cabazitaxel (a chemotherapy drug) with Abiraterone (a new type of hormone therapy) and Enzalutamide (an oral drug) for the treatment of castration-resistant prostate cancers that express poor outcomes

Systemic therapy trial

ACE-LY-308 : A Phase 3, Randomized, Double-blind, Placebo-controlled, Multicenter Study of...

This phase III trial is evaluating an oral drug (acalabrutinib) in combination with two other drugs (bendamustine and rituximab) for the treatment of Mantle Cell Lymphoma

Systemic therapy trial

oral AG-120 : A Phase 1b/2 Open-label, Randomized Study of 2 Combinations of Isocitrate Dehydrogenase...

This phase I/II trial is assessing azacitidine (a chemotherapy drug) with one of two oral drugs (AG-120 or AG-221) for the treatment of Acute Myeloid Leukaemia (AML)

Systemic therapy trial

HMPL-523 : A Phase I, Open-label, Dose-escalation Study of the Safety and Pharmacokinetics of...

This phase I trial is evaluating a drug (HMPL-523) in patients with Chronic Lymphocytic Leukaemia, Lymphoma and Multiple Myeloma

Systemic therapy trial

CHRONOS-4 : A Phase III, Randomized, Double-blind, Controlled Multicenter Study of Intravenous PI3K...

This phase III trial is adding the investigational drug copanlisib, to standard immunochemotherapy (R-B or R-CHOP) for patients with Non Hodgkin Lymphoma

Systemic therapy trial

AALL0932 : Treatment of Patients With Newly Diagnosed Standard Risk B-Precursor Acute Lymphoblastic...

This phase III trial is evaluating different combinations of chemotherapy for the treatment of children who have Lymphoblastic Leukaemia or Lymphoblastic Lymphoma

Systemic therapy trial

NC96 : A phase III randomized study of humanized anti-IL-6 receptor antibody Tocilizumab (TCZ)...

This phase III trial is evaluating tocilizumab (an immunosuppressant) as a way of preventing acute graft versus host disease (GVHD) in patients with Acute Leukaemia

Systemic therapy trial

JASMINE : A Randomized, Double-Blind Study Evaluating the Efficacy, Safety and Immunogenicity of...

This phase III trial is comparing an investigational drug (ABP 798) with rituximab (another drug) for the treatment of B-Cell Non Hodgkin Lymphoma

Systemic therapy trial

AALL1131 : A Phase III Randomized Trial for Newly Diagnosed High Risk B-precursor Acute...

This phase III trial is trying to determine how well combination chemotherapy works in treating young patients with newly diagnosed B-Cell Acute Lymphoblastic Leukemia that is likely to come back or spread

Systemic therapy trial

Idelalisib : Dose Optimization Study of Idelalisib in Follicular Lymphoma or Small Lymphocytic Lymphoma

This phase III trial is assessing the long term administration of a chemotherapy drug (idelalisib) in patients with Follicular Lymphoma

Systemic therapy trial

VITAL : A Phase 3, Randomized, Multicenter, Double-Blind, Placebo-Controlled, 2-Arm, Efficacy and...

This phase III trial is evaluating the investigational agent NEOD001, as an addition to standard therapy in patients with Amyloidosis

Multiple treatment types

Checkmate 548 : A Randomized Phase 2 Single Blind Study of Temozolomide Plus Radiation Therapy Combined...

This phase II trial is comparing outcomes for patients with newly diagnosed Glioblastoma who receive temozolomide plus radiation therapy, with patients who also receive nivolumab

Multiple treatment types

SJMB12 : A Clinical and Molecular Risk-Directed Therapy for Newly Diagnosed Medulloblastoma (Other...

This phase II trial will assess the effectiveness of different Medullablastoma treatments in patients, according to their clinical risk and molecular subtype

Multiple treatment types

CONTROL NETS : Capecitabine ON Temozolomide Radionuclide Therapy Octreotate Lutetium-177 NeuroEndocrine...

This phase II trial is evaluating a radionuclide therapy and a chemotherapy, alone and in combination, for the treatment of gastro neuroendocrine tumours

Systemic therapy trial

Checkmate 577 : A Randomized, Multicenter, Double Blind, Phase III Study of Adjuvant Nivolumab or Placebo...

This phase III trial is trying to determine how effective nivolumab is in the treatment of surgically removed oesophageal and gastro-oesophageal junction cancers

Systemic therapy trial

LDK378 : A Multi-center, Open-label Study to Assess the Safety and Efficacy of Combination...

This phase I trial is trying to determine the safety and effectiveness of two drugs (Ceritinib and Nivolumab), in the treatment of ALK + Non-Small Cell (NSC) Lung Cancer

Systemic therapy trial

KEYNOTE-407 : A Randomized, Double-Blind, Phase III Study of Carboplatin-Paclitaxel/Nab-Paclitaxel...

This phase III trial is testing carboplatin and paclitaxel (or nab-paclitaxel) alone and in combination with pembrolizumab for the treatment of Non-Small Cell (NSC) Lung Cancer, in adults, that has spread to other parts of the body

Systemic therapy trial

B7461001 : Phase 1/2 Study Of PF-06463922 (An ALK/ROS1 Tyrosine Kinase Inhibitor) In Patients With...

This phase I/II trial is testing the drug PF-06463922 in patients with ALK+ and ROS1+ advanced Non-Small Cell (NSC) Lung Cancer

Systemic therapy trial

CT853 : A Phase III, Randomized, Open Label Trial of Nivolumab in Combination With Ipilimumab...

This phase III trial will compare the effectiveness of two immunotherapy drugs (Nivolumab and Ipilimumab), with three chemotherapy drugs (Pemetrexed and Cisplatin or Carboplatin) in patients with pleural mesothelioma

Systemic therapy trial

Javelin Lung 101 : A Phase 1b/2, Open-Label, Dose-Finding Study To Evaluate Safety, Efficacy,...

This phase I/II trial is evaluating the safety and effictiveness of avelumab (an immunotherapy drug) when it is combined with one of two anti-cancer drugs (crizotinib or PF-06463922) for the treatment of Non Small Cell (NSC) Lung Cancer

Systemic therapy trial

GO29527 : A Phase III, Open-label, Randomized Study to Investigate the Efficacy and Safety of...

This phase III trial is evaluating the safety and effectiveness of having 16 cycles of atezolizumab chemotherapy, instead of best supportive care, in patients who have had surgery and adjuvant chemotherapy, for stage IB-IIIA Non-Small Cell (NSC) Lung Cancer

Systemic therapy trial

CT753 : A Phase Ib/II, Multicenter, Open-label Study of EGF816 in Combination With INC280 in...

This phase Ib/II trial is trying to determine the preliminary effect of combining two drugs (EGF816 and INC280), in the treatment of advanced Non-Small Cell (NSC) Lung Cancer

Systemic therapy trial

CT837 : A Phase 2, Randomized Study of MLN0128 (a Dual TORC1/2 Inhibitor), MLN0128+MLN1117 (a...

This phase II trial is trying to determine what effect adding an oral drug (MLN1028) to weekly paclitaxel will have in the treatment of advanced, recurrent or persistant Endometrial Cancer

Systemic therapy trial

CheckMate 651 : An Open Label, Randomized, Two Arm Phase III Study of Nivolumab in Combination With...

This phase III trial is comparing immunotherapy (with nivolumab and ipilimumab) with the 'extreme study regimen' as a first line treatment for patients with a squamous cell carcinoma of the head and neck that has come back or has spread to other parts of the body

Systemic therapy trial

EXAMINER : A Randomized, Double-blind Study To Evaluate the Efficacy and Safety of Cabozantinib...

This phase IV trial is assessing two doses (60mg and 140mg) of an oral drug (cabozantinib) in the treatment of progressive, metastatic Medullary Thyroid Cancer (MTC)

Multiple treatment types

HPVOropharynx : (TROG 12.01)A Randomised Trial of Weekly Cetuximab and Radiation Versus Weekly Cisplatin...

This phase III trial is comparing two types of standard treatment for patients with advanced HPV-associated oropharyngeal cancer, which will be given in combination with radiation therapy

Systemic therapy trial

LDE225 : A stratified multi-arm Phase 2 study evaluating the efficacy and safety of LDE225 in...

This phase II trial is evaluating the oral drug LDE225 for the treatment of patients whose sarcoma has spread to other parts of the body

Systemic therapy trial

EWING 2008 : Phase 3, Open Label, Multi-centre, Randomised Controlled International Study in Ewing...

This phase III trial is trying to assess whether the addition of three different drugs, to prescribed chemotherapy treatment, will improve survival outcomes for people with Ewing's Sarcoma

Systemic therapy trial

Announce 2 : A Phase 1b (Open-Label) / Phase 2 (Randomized, Double-Blinded) Study Evaluating...

This phase I/II trial is assessing the safety and effectiveness of two anti-cancer drugs (gemcitabine and docetaxel) alone and in combination with olaratumab (the study drug) for the treatment of patients with advanced soft tissue sarcoma that has spread to other parts of the body

Multiple treatment types

CA184-325 : Radiotherapy and Ipilimumab in Metastatic Melanoma

This phase I/II trial is combining ipilimumab and radiotherapy for the treatment of metastatic melanoma

Systemic therapy trial

Regeneron 2 : A Phase 2 Study of REGN2810, a Fully Human Monoclonal Antibody to Programmed Death-1...

This phase II trial is evaluating the drug REGN2810 as a monotherapy for people with metastatic or locally advanced cutaneous squamous cell carcinoma (CSCC)

Multiple treatment types

RTN2 : A Randomised Trial of Post-operative Radiation Therapy Following Wide Excision of...

This phase III trial is comparing surgery alone and in combination with radiation therapy for the treatment of primary melanoma that has histoglogical features of neurotropism

Systemic therapy trial

SETUP : Neoadjuvant chemotherapy with docetaxel and anthracycline based chemotherapy in patients...

This phase III trial is assessing the safety and effectiveness of neoadjuvant chemotherapy, with docetaxel and anthracycline, in patients with advanced breast cancer

Surgical trial

Irreversible Electroporation : The safety and efficacy of Irreversible Electroporation for the ablation of prostate...

This trial is assessing the safety and efficacy of Irreversible Electroporation for the removal of prostate cancer

Systemic therapy trial

m-BEP : A Phase 1b Study of Bcl-2 inhibition with ABT-199 in combination with Tamoxifen in...

This phase I trial is assessing the safety and effect of combining ABT-199 with tamoxifen (a hormone therapy) in the treatment of oestrogen recepter positive breast cancer

Multiple treatment types

Yttrium-90 : A pilot study of combined modality treatment for hepatic metastases of uveal melanoma...

This phase I trial is combining radiation therapy and chemotherapy for patients with Uveal Melanoma (a cancer of the eye) that has spread to the liver

Systemic therapy trial

anti-fucosyl-GM1 : A Phase 1/2 Multicenter Study of BMS-986012 in Subjects With Relapsed/Refractory Small...

This phase I/II trial is investigating BMS-986012 alone and in combination with nivolumab for the treatment of relapsed or refractory Small Cell Lung Cancer (SCLC)

Systemic therapy trial

CT852 : A Phase 1/2 Randomized Trial of BMS-986012 in Combination With Platinum and Etoposide as...

This phase I/II trial is testing the drug BMS-986012 in combination with Platinum and Etoposide therapy, as first line treatment for people with extensive Small Cell Lung Cancer (SCLC)

Systemic therapy trial

Keynote-252 : A Phase 3 Randomized, Double-Blind, Placebo-Controlled Study of Pembrolizumab (MK-3475)...

This phase III trial is comparing pembrolizumab (immunotherapy) alone and in combination with epacadostat (an oral drug) for people with metastatic melanoma

Surgical trial

MelMarT Trial : A Phase III, multi-centre, multi-national randomised control trial investigating 1cm v...

This phase III trial is trying to determine whether a smaller surgical margin will be effective in the removal of primary cutaneous melanoma and improve patient quality of life

Radiotherapy trial

TROG 08.05 : Whole brain radiotherapy following local treatment of intracranial metastases of...

This phase III trial is assessing whole brain radiotherapy following local treatment for people with melanoma spread to the brain

Surgical trial

EAGLE FM : Inguinal or Ilio-inguinal Lymphadenectomy for patients with metastatic melanoma to groin...

This phase III trial is evaluating two surgical procedures (Inguinal or Ilio-inguinal Lymphadenectomy) for the removal of metastatic melanoma in the lymph nodes of the groin

Systemic therapy trial

ACE-CL-006 : A Randomized, Multicenter, Open-Label, Non-Inferiority, Phase 3 Study of ACP-196 Versus...

This phase III trial is evaluating two drugs (acalabrutinib and ibrutinib) for the treatment of patients who have been diagnosed Chronic Lymphocytic Leukemia (CLL)

Systemic therapy trial

CX-5461 : A Phase 1, Open-Label, Dose Escalation, Safety, Pharmacokinetic, and Pharmacodynamic...

This phase I trial is evaluating an intravenously administered drug (CX-5461) for the treatment of advanced blood cancer

Systemic therapy trial

RePLY : ALLG NHL26 A Phase 2 Study of patients treated for relapsed Follicular Lymphoma: with...

This phase II trial is evaluating the combination of revlimid (chemotherapy) and rituximab maintenance therapy in the treatment of patients with Follicular Lymphoma

Systemic therapy trial

AML-001 : A Phase 3, Randomized, Double-blind, Placebo-controlled Study to Compare Efficacy and...

This phase III trial is comparing best supportive care with and without oral azacitidine (chemotherapy) as a maintenance therapy for patients in remission for Acute Myeloid Leukaemia (AML)

Systemic therapy trial

NMP : A Phase I, Open Label Dose Escalation Trial of Orally Administered N-methyl-pyrrolidone...

This phase I trial is evaluating an oral drug (N-methyl-pyrrolidone) in patients with relapsed Myeloma

Systemic therapy trial

CT803 : A Phase 1 First in Human Study Evaluating the Safety, Tolerability, Pharmacokinetics and...

This phase I trial is evaluating an investigational drug (AMG 176) in patients with Multiple Myeloma

Systemic therapy trial

AIM study : A Phase 2 Study of ABT-199 in Combination With Ibrutinib in the Treatment of Patients...

This phase II trial is assessing the combination of two drugs (ABT-199 and irutinib) for the treatment of Mantle Cell Lymphoma

Systemic therapy trial

SCRAMBLE : Chemotherapy Followed by Infusion of Partially HLA Matched Unrelated Donor Cells for...

This phase I trial will involve infusion of donor blood or marrow cells in patients with Acute Myeloid Leukaemia (AML), following consolidation chemotherapy

Systemic therapy trial

IDHENTIFY : A Phase 3, Multicenter, Open-label, Randomized Study Comparing the Efficacy and Safety of...

This phase III trial is comparing an investigational drug (AG-221) with standard treatment in older patients with Acute Myeloid Leukaemia (AML)

Systemic therapy trial

CT711 : A Phase I/II Open-label, Dose Escalation Study to Investigate the Safety,...

This phase I/II trial is evaluating an oral drug (GSK525762) for the treatment of relapsed or refractory haematological conditions

Systemic therapy trial

BGB-3111 : A Phase IA, Open Label, Multiple Dose, Dose Escalation Study to Investigate the Safety...

This phase I trial is investigating a new drug (BGB3111) for the treatment of B-Cell Lymphomas

Systemic therapy trial

S055746 : Phase I dose-escalation study of the orally administrered selective Bcl-2 inhibitor...

This phase I trial is assessing the oral administration of the drug S 055746 in patients with Acute Myeloid Leukaemia or Myelodysplastic Syndrome

Systemic therapy trial

16-Dec : A Phase 1b, Open Label, Multiple Dose, Dose Escalation and Expansion Study to Assess...

This phase I trial is evaluating the oral drug BGB-3111 in combination with BGB-A317 for patients with B-Cell Lymphoma

Systemic therapy trial

CC-486 : A Phase 2, International, Multicenter, Randomized, Open-label, Parallel Group to Evaluate...

This phase II trial is evaluating an oral drug (Cc-486) alone and in combination with a type of immunotherapy (durvalumab/ MEDI4736) in patients with Myelodysplastic Syndromes

Systemic therapy trial

ALLG AML M16 : Sorafenib in combination with intensive chemotherapy for previously untreated adult...

This phase II trial is investigating the role of the drug sorafenib, given in combination with intensive chemotherapy for the treatment of Acute Myeloid Leukaemia (AML)

Systemic therapy trial

KEYNOTE-177 : A Phase III Study of Pembrolizumab (MK-3475) vs. Chemotherapy in Microsatellite...

This phase III trial is comparing an immunotherapy drug (pembrolizumab) with chemotherapy in the treatment of stage IV colorectal cancer

Systemic therapy trial

CT787 : A Non-Randomised Open-Label Phase Ib Exploratory Study of TG02-treatment as Monotherapy...

This phase Ib trial is testing an investigational TG02 treatment in patients with locally recurrent rectal cancer

Systemic therapy trial

CT820 : A Phase 3, Randomized, Double-Blind, Placebo-Controlled, Multicenter Study of PEGylated...

This phase III trial is evaluating nab-paclitaxel and gemcitabine (chemotherapy) alone and in combination with PEGylated Recombinant Human Hyaluronidase (PEGPH20) for the treatment of stage IV previously untreated pancreatic ductal adenocarcinoma

Systemic therapy trial

Javelin Bladder 100 : A Phase 3, Multicenter, Multinational, Randomized, Open-label, Parallel-arm Study Of...

This phase III trial is comparing maintenance treatment with avelumab and best standard care, with best standard care alone, in patients with advanced urothelial cancer

Systemic therapy trial

EMBARK : A Phase 3, Randomized, Efficacy and Safety Study of Enzalutamide Plus Leuprolide,...

This phase III trial is assessing the safety and efficacy of using enzalutamide and leuprolide in patients with non metastatic prostate cancer, after radical prostatectomy, radiotherapy or both

Systemic therapy trial

PRE-TREAT : A window study to determine short-term effects of Pre-operative Treatment with tamoxifen...

This study is trying to determine the effects of having short term endocrine therapy (tamoxifen or letrozole) in the treatment of newly diagnosed oestrogen receptor positive breast cancer

Systemic therapy trial

PIKNIC : A Phase II Exploratory, Open-label, Single Arm Study of BYL719 Monotherapy, a Selective...

This phase II trial is investigating the oral drug BYL719 as a monotherapy for people with advanced metastatic breast cancer after first line treatment

Systemic therapy trial

CT618 : A Phase Ib/II, Multicenter Study of the Combination of LEE011 and BYL719 With Letrozole...

This phase I trial is investigating the future development of LEE011 and BYL719 in the treatment of advanced oestrogen receptor positive breast cancer

Systemic therapy trial

ALLG ALL07 : Phase 1 study investigating the safety and tolerability of RAD001 (Everolimus) in...

This phase I trial is evaluating a new drug (Everolimus) in combination with chemotherapy for the treatment of Acute Lymphoblastic Leukaemia (ALL)

Systemic therapy trial

M14-031 : A Phase 3, Multicenter, Randomized, Double Blind Study of Bortezomib and Dexamethasone in...

This phase III trial is evaluating two drugs (bortezomib and dexamethasone) in combination with a chemotherapy drug (venetoclax) for the treatment of Multiple Myeloma

Systemic therapy trial

HCT versus CT : Randomized Phase III Study Comparing Conventional Chemotherapy to Low Dose Total Body...

This phase III trial is comparing two types of consolidation therapy (standard chemotherapy and hematopoietic cell transplantation) for patients in complete remission for Acute Myeloid Leukaemia (AML)

Systemic therapy trial

ALLG MM16 : Phase II study assessing the effect of carfilzomib treatment on early free light chain...

This phase II trial is assessing carfilzomib (an anti-cancer drug) in patients with Multiple Myeloma who suffer from renal damage

Systemic therapy trial

PANORAMA_3 : A Multicenter, Randomized, Open-label Phase 2 Study Evaluating the Safety and Efficacy of...

This phase II trial is evaluating three ways to administer an oral drug (panobinostat) in combination with chemotherapy (subcutaneous bortezomib) and steroids (dexamethasone) for the treatment of Multiple Myeloma

Systemic therapy trial

CARINA : An Open Label, Phase 2 Study to Evaluate Efficacy and Safety of Daratumumab in Relapsed...

This phase II trial is evaluating an anti-cancer drug (daratumumab) for the treatment of Follicular, Mantle Cell and Diffuse Large Cell Lymphoma

Systemic therapy trial

CR107273 : A Randomized Phase 2/3 Study of DACOGEN® (Decitabine) Plus JNJ-56022473 (Anti CD123)...

This phase II/III trial is evaluating the investigational drug, talacotuzumab, alone and in combination with decitabine (an anti-cancer chemotherapy) for the treatment of Acute Myeloid Leukaemia (AML)

Systemic therapy trial

C16021 : A Phase 3, Randomized, Placebo-Controlled, Double-Blind Study of Oral Ixazomib...

This phase III trial is testing an oral chemotherapy drug (ixazomib) as a maintenance therapy for patients with newly diagnosed Multiple Myeloma

Systemic therapy trial

M17 : A Strategy of High-Dose Lenalidomide in Combination with Epigenetic Therapies for...

This phase I trial is evaluating a chemotherapy drug (lenalidomide) with epigenetic therapy for the treatment of Acute Myeloid Leukaemia (AML)

Systemic therapy trial

TREATT : A double blind, randomised controlled TRial EvaluAting the safety and efficacy of...

This phase III trial is trying to determine whether it is effective to give tranexamic acid (a drug that reduces heavy bleeding) to patients with Thrombocytopenia

Systemic therapy trial

ITD : A prospective, multi-centre, single arm, phase 2 assessment of the efficacy and safety of...

This phase II trial is combining three drugs (ixazomib, thalidomide and a steroid) for the treatment of relapsed and/or refractory multiple myeloma

Systemic therapy trial

PIM447 : A Phase Ib, Multi-center, Open-label, Dose-escalation Study of PIM447 in Combination With...

This phase I trial is evaluating the investigational agent, PIM447, in combination with ruxolitinib (a targetted therapy) and LEE011 (an oral drug) for the treatment of Myelofibrosis

Systemic therapy trial

AAML1031 : A Phase III Randomized Trial for Patients With de Novo AML Using Bortezomib and Sorafenib...

This phase III trial is evaluating bortezomib (a chemotherapy drug) and sorafenib tosylate (another type of drug) for the treatment of newly diagnosed Acute Myeloid Leukaemia (AML)

Systemic therapy trial

CFZ008 : Phase 1b/2 Study of Carfilzomib in Combination With Dexamethasone, Mitoxantrone,...

This phase I/II trial is trying to determine how much carfilzomib (an anti-cancer drug) should be used, alone and in combination with induction chemotherapy, to treat children with Acute Lymphoblastic Leukaemia (ALL)

Systemic therapy trial

CHRONOS-3 : A Phase III, Randomized, Double-blind, Placebo-controlled Study Evaluating the Efficacy...

This phase III trial is evaluating the drug rituximab, alone and in combination with copanlisib (another drug), for the treatment of Non Hodgkin Lymphoma

FORUM : Allogeneic Stem Cell Transplantation for Children and Adolescents With Acute...

This phase II/III trial is evaluating allogenic stem cell transplatation as an optimal therapy for children and adolescents diagnosed with Acute Lymphoblastic Leukaemia (ALL)

Systemic therapy trial

IXAZOMI : A Phase 3, Randomized, Controlled, Open-label, Multicenter, Safety and Efficacy Study of...

This phase III trial is comparing dexamethasone (a steroid) and an oral drug (MLN9708) with another treatment (chosen by the investigator) in patients with relapsed Amyloidosis

Systemic therapy trial

Oral LGH447 : A Phase I, Multicenter, Open-label Study of Oral LGH447 in Patients With Acute Myeloid...

This phase I trial is evaluating an oral drug (LGH447) alone and in combination with midostaurin for the treatment of Acute Myeloid Leukaemia or Myelodysplastic Syndrome

Systemic therapy trial

GSK200200 - LSD1 : A Phase I Open-label, Dose Escalation Study to Investigate the Safety, Pharmacokinetics,...

This phase I trial is assessing an oral drug (GSK2879552) in patients with relapsed Acute Myeloid Leukaemia (AML)

Systemic therapy trial

NCT02393859 : Phase 3 Trial to Investigate the Efficacy, Safety, and Tolerability of Blinatumomab as...

This phase III trial is trying to determine whether blinatumomab (a drug) is better as a consolidation therapy than standard chemotherapy for patients with Acute Lymphoblastic Leukaemia (ALL)

Systemic therapy trial

AMG 224 : A Phase 1 First in Human Study Evaluating the Safety, Tolerability, Pharmacokinetics and...

This phase I trial is evaluating the drug AMG 224 as a treatment for Multiple Myeloma in patients who have relapsed

Systemic therapy trial

RV-003607 : Lenalidomide consolidation post allogeneic stem cell transplant for patients with high...

This phase II trial is evaluating lenalidomide as a maintenance therapy for patients with high risk multiple myeloma who have receivied an allogenic stem cell transplant

Multiple treatment types

Intellance 1 : A Randomized, Placebo Controlled Phase 2b/3 Study of ABT-414 With Concurrent...

This phase II trial is trying to determine whether adding the drug ABT-414 to radiotherapy and standard chemotherapy with temozolomide, is effective in improving the survival of patients with newly diagnosed Glioblastoma (GBM)

Multiple treatment types

ACNS0831 : Phase III Randomized Trial of Post-Radiation Chemotherapy in Patients With Newly...

This phase III trial is comparing post-radiation chemotherapy and observation for the treatment of young people with newly diagnosed ependymomas

NAT-105 : A Feasibility Study of the Nativis Voyagerâ„¢ System in Patients With Recurrent...

This study will assess the effects of Nativis Voyager therapy in patients with recurrent Glioblastoma (GBM).

Surgical trial

SNAC2 : A randomised phase III study to determine in women with early breast cancer whether...

This phase III trial is assessing the effect of sentinal node based management on risk of recurrence in patients with early stage breast cancer

Systemic therapy trial

InterAACT : An International Multicentre Open Label Randomised Phase II Advanced Anal Cancer Trial...

This phase II trial is comparing two different chemotherapy regimens for the treatment of patients with inoperable, locally recurrent or metastatic (advanced) anal cancer.

Systemic therapy trial

CheckMate 649 : A Randomized, Multicenter, Open-Label, Phase 3 Study of Nivolumab Plus Ipilimumab or...

This phase III trial trying to compare the relative survival of patients who receive either (i) nivolumab and ipilimumab (ii) nivolumab and chemotherapy or (iii) chemotherapy alone for the treatment of oesophageal and gastro-oesophageal junction cancers

Systemic therapy trial

CELESTIAL : A Phase 3, Randomized, Double-blind, Controlled Study of Cabozantinib (XL184) vs Placebo...

This phase III trial is evaluating cabozantinib (XL184) as a follow up treatment for advanced hepatocellular (liver) cancer

Systemic therapy trial

PCR-MIB study : Pembrolizumab With Chemoradiotherapy as Treatment for Muscle Invasive Bladder Cancer

This phase II study is assessing the safety and feasibility of combining pembrolizumab (an immunotherapy agent) with chemoradiotherapy in the treatment of bladder cancer

Systemic therapy trial

WO29636 : A Phase III, Open-Label, Multicenter, Randomized Study of Atezolizumab (Anti-PD-L1...

This phase III trial will evaluate the safety and efficacy of adjuvant treatment with the drug atezolizumab, compared with observation, in patients with urothelial cancer who are at high risk of recurrence following surgery.

Surgical trial

Sentinal : Prospective collection of clinical data following sentinel node biopsy for vulval...

This trial will collect data following a sentinal node biopsy in patients with vulval carcinoma

Systemic therapy trial

Rare cancers : A Phase II Clinical Trial Evaluating Ipilimumab and Nivolumab in Combination for the...

This phase II trial is evaluating two immunotherapy drugs (Ipilimumab and Nivolumab) for the treatment of rare gastrointestinal, neuroendocrine and female reproductive cancers

Systemic therapy trial

A Phase 1A/1B Multicenter, Open-label, Dose-escalation, and Dose-expansion Study to...

This phase I trial is evaluating a new biological therapy (AK-104) in adult patients with advanced solid cancers (excluding some blood cancers)

Systemic therapy trial

A Multicenter, Phase 1, Open-Label, Dose-Escalation Study of ABBV-181, a Monoclonal...

This phase I trial is combining two anti-cancer therapies (ABBV-181 and Rovalpituzumab Tesirine) in patients with advanced solid tumours

Radiotherapy trial

SAFRON II : A Randomised Phase II Trial to Evaluate the Toxicity, Quality of Life, Clinical Efficacy...

This phase II trial is comparing ablative fractionated radiotherapy and radiosurgery in patients with advanced cancer that has spread to the lung

Radiotherapy trial

CORE : A Randomised Trial of Conventional Care Versus Radioablation (Stereotactic Body...

This phase II/III trial is comparing standard of care techniques for patients with Prostate, Breast or Non-Small Cell (NSC) Lung cancer, with a type of stereotactic body radiotherapy

Systemic therapy trial

A Phase I, Open Label, Multicenter Study of the Safety and Efficacy of MIW815 (ADU-S100)...

This phase I trial is combining to drugs (PDR001 and MIW815) for the treatment of advanced solid cancers and Lymphomas

Systemic therapy trial

CP-MGA271-03 : A Phase 1, Open-Label, Dose Escalation Study of MGA271 in Combination With Pembrolizumab...

This phase I trial is combining two biological therapies (Enoblituzumab and Pembrolizumab) in patients with Melanoma, Squamous Cell Carcinoma of the Head and Neck, Non-Small Cell (NSC) Lung Cancer, Urothelial Cancer and other B7-H3 expressing cancers

Systemic therapy trial

A Phase I, Open-Label, Multicenter, Non-Randomized, Dose-Escalation Study to Evaluate the...

This phase I trial is evaluating an oral drug (HTI-1090) for the treatment of advanced solid tumours

Systemic therapy trial

SHR3162 : A Multicenter, Open-Label, Phase 1 Trial of SHR3162 Given Orally to Subjects With...

This phase I trial is evaluating a new drug (SHR3162) in patients with advanced cancers (excluding blood cancer)

Systemic therapy trial

M7824 : A Phase I, Open-label, Multiple-ascending Dose Trial to Investigate the Safety,...

This phase I trial is assessing a new drug known as M7824, given to patients with a solid cancer (not blood) every two weeks

Systemic therapy trial

STARTRK-2 : An Open-Label, Multicenter, Global Phase 2 Basket Study of Entrectinib for the Treatment...

This phase II trial is evaluating an investigational drug (entrectinib) for the treatment of patients with solid cancers that express the NTRK1/2/3, ROS1 or ALK gene

Systemic therapy trial

IMagyn050 : A Phase III, Multicenter, Randomized, Study of Atezolizumab Versus Placebo Administered...

This phase III trial is trying to determine the effect of combining atezolizumab and three other drugs (paclitaxel, carboplatin and bevacizumab) in patients with ovarian, fallopian tube or peritoneal cancer

Systemic therapy trial

ENG8 : A Phase 1 Study of Anti-Human EGFR (Vectibix Sequence) Targeted EDVs Carrying the...

This phase I trial is using a new technology (EDV) to deliver chemotherapy (PNU-159682) and immunotherapy (EDVs40-mer) drugs in patients with advanced solid tumours

Systemic therapy trial

CT898 : A Phase 1 First Time in Human Study to Evaluate the Safety, Pharmacokinetics and...

This phase I trial is comparing a biological therapy (MEDI5083) alone and in combination with an immunotherapy agent (Durvalumab) for the treatment of select advanced cancers

Systemic therapy trial

STORM : A Phase 1, Dose-finding and Signal-seeking Study of the Safety and Efficacy of...

This phase I trial is evaluating an intravenously administered immunotherapy (CAVATAK) alone and in combination with pembrolizumab, for the treatment of non-small cell lung cancer, prostate cancer, melanoma and bladder cancer

Systemic therapy trial

CT789 : A Phase 1/2a Study of BMS-986205 Administered in Combination With Nivolumab (Anti-PD-1...

This phase I/II immunotherapy trial is using a new drug (BMS-986205) in combination with Nivolumab and Ipilimumab for the treatment of cancers that are advanced or have spread

Systemic therapy trial

CT855 : A Phase I, Open-label, Multi-center, Dose Escalation Study to Assess the Safety,...

This phase I trial is trying to determine whether or not the drug HMPL-453 is effective in treating patients with advanced cancers (excluding blood cancer)

Systemic therapy trial

ABBV-927 : A Multi-Center, Phase 1, Open-Label, Dose-Escalation Study of ABBV-927, an...

This phase I trial is evaluating ABBV-927 (an immunotherapy) alone and in combination with nivolumab for the treatment of advanced cancer

Systemic therapy trial

EZ7438 : An Open-Label, Multicenter, Phase 1/2 Study of E7438 (EZH2 Histone Methyl Transferase...

This phase I/II trial is evaluating an oral drug (tazemetostat) alone and in combination with a steroid (prednisolone) for the treatment of advanced solid cancers and patients with B Cell Lymphoma

Systemic therapy trial

CBT-501 : A Phase 1 Multicenter, Dose Escalation Study of CBT-501 in Subjects With Select Advanced...

This phase I trial is trying to determine how safe and effective CBT-501 is in individuals with an advanced solid cancer (excluding blood cancer) that has gotten worse or come back

Systemic therapy trial

INDUCE-1 : A Phase I Open Label Study of GSK3359609 Administered Alone and in Combination With...

This phase I trial is evaluating a new drug (GSK3359609) administered alone and in combination with an anticancer agent (pembrolizumab) for the treatment of advanced cancer

Systemic therapy trial

CT822 : A Phase1b/2 Study Assessing Safety and Anti-tumor Activity of AMG 820 in Combination With...

This phase I/II trial is combining two drugs (AMG 820 and pembrolizumab) for the treatment of advanced Pancreatic, Colorectal and Non Small Cell Lung Cancer

Systemic therapy trial

CT829 : A Phase I/II Study of Safety and Efficacy of Ribociclib (LEE011) in Combination With...

This phase I/II trial is evaluating two drugs (ribociclib and trametinib) for the treatment of advanced cancers (excluding blood cancer)

Treatment trial

CT832 : A Phase 1/1b, Open-Label, Multicenter, Repeat-Dose, Dose-Selection Study of CPI-444 as...

This phase I trial is evaluating a new drug (CPI-444) alone and in combination with atezolizumab in patients with advanced cancers

Systemic therapy trial

BMS-986148 : A Phase I/IIa Study of BMS-986148, a Mesothelin Directed Antibody Drug Conjugate, in...

This phase I trial is evaluating two drugs (BMS-986148 and nivolumab) alone and in combination for the treatment of select advanced cancers

Systemic therapy trial

KEYNOTE-051 : A Phase I/II Study of Pembrolizumab (MK-3475) in Children With Advanced Melanoma or a...

This phase I/II trial is evaluating pembrolizumab (an immunotherapy drug) in children with advanced Melanoma, PD-L1 positive solid cancer or Lymphoma

Systemic therapy trial

CT680 : A Dose-Finding Phase 1 Study of TAS-120 in Patients With Advanced Solid Tumors With or...

This phase I/II trial is evaluating an oral drug (TAS-120) in patients with an advanced solid cancer or Multiple Myeloma

Systemic therapy trial

CT830 : A Phase I/II Open-Label, Dose Escalation Study to Investigate the Safety,...

This phase I/II trial is evaluating a new drug (GSK525762) for select midline and advanced cancers

Systemic therapy trial

A8081001 : Phase 1 Safety, Pharmacokinetic And Pharmacodynamic Study Of PF-02341066, A c-Met/HGFR...

This phase I trial is evaluating a new oral drug (PF-02341066) in patients with advanced cancer (excluding Leukaemia)

Systemic therapy trial

IMP4297 : A Phase I, Open-label, Dose-escalation Study of the Safety and Pharmacokinetics of...

This phase I trial is evaluating a new drug (IMP4297) for the treatment of advanced cancers (excluding blood cancer)

Systemic therapy trial

EBC-46 extension study : Phase I Dose-Escalation Extension Study to Determine the Safety and Tolerability of...

This phase I trial is evaluating an injection with EBC-46 in patients with skin cancer and cancers of the head and neck

Systemic therapy trial

EBC-46 : Phase I Dose-Escalation Study to Determine the Safety and Tolerability of an...

This phase I trial is evaluating an intratumoural injection in patients with skin cancer and cancers of the head and neck

Systemic therapy trial

APG-1387 : A phase 1, open label, multi-center, dose escalation study of the safety, tolerability,...

This phase I trial is evaluating an intravenously (in the vein) administered drug (APG-1387) in patients with advanced solid cancers or Lymphoma

Systemic therapy trial

Rap CV : A phase I study of vinorelbine, cyclophosphamide and Rapamycin for recurrent malignancies...

This phase I trial is evaluating chemotherapy for the treatment of children with a cancer that has come back

Radiotherapy trial

SHRINC : A Phase II Prospective Trial of Stereotactic Hypofractionated Radiation for Multiple...

This phase II trial is assessing a type of radiotherapy treatment for patients whose cancer has spread to the brain

Systemic therapy trial

TIGIT : A Phase Ia/Ib Open-Label, Dose-Escalation Study of the Safety and Pharmacokinetics of...

This phase I trial is evaluating a new drug (MTIG7192A) alone and in combination with atezolizumab (an immunotherapy drug) for the treatment of advanced cancer

Systemic therapy trial

KEYNOTE-158 : A Clinical Trial of Pembrolizumab (MK-3475) Evaluating Predictive Biomarkers in Subjects...

This phase II trial is testing pembrolizumab (an immunotherapy drug) in patients with advanced cancers that have not responded (or worsened) on standard treatment

Systemic therapy trial

PUMA : An Open-label, Multicenter, Multinational, Phase 2 Study Exploring the Efficacy and...

This phase II trial is evaluating neratinib (targeted) therapy in patients that have solid cancers with activating HER2, HER3 or EGFR mutations

Systemic therapy trial

A317/290 : A Phase 1b, Open Label, Multiple Dose, Dose Escalation and Expansion Study to Investigate...

This phase I trial is combining BGB-A317 and BGB-290 for the treatment of advanced cancers (excluding blood cancer)

Systemic therapy trial

REGN2810 : A First-in-Human Study of Repeat Dosing With REGN2810, a Monoclonal, Fully Human Antibody...

This phase III trial is evaluating REGN2810, alone and in combination with other anti-cancer therapies, for the treatment of advanced cancer

Systemic therapy trial

GO29313 : A PHASE I, OPEN-LABEL, DOSE-ESCALATION STUDY OF THE SAFETY AND PHARMACOKINETICS OF...

This phase I trial is assessing an intravenously (in the vein) administered drug (MOXR0916) for the treatment of locally advanced or metastatic solid cancers (excluding blood cancer)

Systemic therapy trial

ACT001 : A phase 1 dose-escalation study to evaluate the safety, tolerability and pharmacokinetics...

This phase I trial is evaluating the study drug ACT001 in patients with advanced (solid) cancers

Systemic therapy trial

Beigene 2 : A Phase IA, Open Label, Multiple Dose, Dose Escalation Study to Investigate the Safety...

This phase I trial is evaluating a new drug known as BGB-290 in patients with solid cancers

Systemic therapy trial

BGB-A317 : A Phase 1, Open Label, Multiple Dose, Dose Escalation and Expansion Study to Investigate...

This phase I trial is evaluating a new drug known as BGB-A317 in patients with advanced cancer

Systemic therapy trial

BRF116013 : Phase I/IIa, 2-Part, Multi-Center, Single-Arm, Open-Label Study to Determine the Safety,...

This phase I trial is evaluating an oral drug (dabrafenib) for children and adolescents with advanced BRAF V600-mutation positive cancers

Systemic therapy trial

LeYPh1-02 : A phase I study investigating the safety and tolerability of an infusion of T lymphocytes...

This phase I trial is assessing a new systemic therapy (LeY CAR-T cell therapy) in patients with solid cancers that express the LeY gene

Systemic therapy trial

CT821 : A Phase 1 Multicenter, Open-label, Dose-escalation and Dose-expansion Study to Evaluate...

This phase I trial is evaluating two drugs (MEDI94 and MEDI4736) alone and in combination for the treatment of adult patients with select solid cancers

Radiotherapy trial

StereoCav : Randomised trial of adjuvant versus delayed stereotactic radiotherapy to resection cavity...

This phase II trial is comparing adjuvant radiotherapy with delayed radiotherapy in people who have previously resected cancer that has spread to the brain

Systemic therapy trial

KEYNOTE-240 : A Phase III Study of Pembrolizumab (MK-3475) vs. Best Supportive Care as...

This phase III trial is evaluating pembrolizumab in patients who have previously received systemic treatment for advanced hepatocellular (liver) cancer

Systemic therapy trial

LDK378 : A Phase I, Open-label, Dose Escalation Study of LDK378 in Pediatric Patients With...

This phase I trial is assessing the recommended dose of LDK378 in children with Anaplastic Lymphoma Kinase (ALK) cancers

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