Results

Systemic therapy trial

Keynote-716 : Adjuvant Therapy With Pembrolizumab Versus Placebo in Resected High-risk Stage II...

This phase III trial is evaluating the safety and effectiveness of the immunotherapy drug, Pembrolizumab, in patients with surgically removed high-risk stage II melanoma

Cancer type : Melanoma (Skin)

Systemic therapy trial

KEYNOTE-348 : A Phase 1b Open Label Study Investigating the Safety and Efficacy of Blinatumomab in...

This phase I trial is combining a new drug (blinatumomab) with a commonly used immunotherapy drug (pembrolizumab) for the treatment of relapsed or refractory Diffuse Large B-Cell Lymphoma (DLBCL)

Cancer type : Blood

Systemic therapy trial

HALO : A Phase 3, Randomized, Double-Blind, Placebo-Controlled, Multicenter Study of PEGylated...

This phase III trial is evaluating nab-paclitaxel and gemcitabine (chemotherapy) alone and in combination with PEGylated Recombinant Human Hyaluronidase (PEGPH20) for the treatment of stage IV previously untreated pancreatic ductal adenocarcinoma

Cancer type : Pancreas

Systemic therapy trial

IRiC : A Phase II Study of Ibrutinib, Rituximab and mini-CHOP (cyclophosphamide, doxorubicin,...

This phase II trial is assessing 6 cycles of chemotherapy in patients with Diffuse Large B-Cell Lymphoma

Cancer type : Diffuse Large Cell Lymphoma

Systemic therapy trial

A Phase 3, Double-blind, Randomized Study of BGB-290 Versus Placebo as Maintenance...

This phase III study is evaluating a drug (BGB-290) as maintenance therapy for the treatment of advanced or inoperable gastric cancer in patients who have previously been treated with platinum based chemotherapy

Cancer type : Stomach

Systemic therapy trial

GO30140 : An Open-Label, Multicenter Phase Ib Study of The Safety and Efficacy of Atezolizumab...

This phase I trial is evaluating the safety and effectiveness of two immunotherapy drugs (atezolizumab and bevacizumab) in combination with other treatments, including chemotherapy, for patients with select solid cancer types

Cancer type : Stomach

Systemic therapy trial

A Randomized, Open-label, Phase II Clinical Trial of Relatlimab (Anti-LAG-3) Plus...

This phase II trial is assessing two immunotherapy drugs (Relatlimab + Nivolumab) in combination with chemotherapy for the treatment of previously untreated, advanced stomach or gastro-oesophageal junction cancers

Cancer type : Stomach

Multiple treatment types

AZTEC : A Randomised Phase II Trial Comparing the Efficacy of Single-fraction or Multi-fraction...

This phase II trial is evaluating radiotherapy and immunotherapy for the treatment of advanced triple negative breast cancer (TNBC)

Cancer type : Breast

Systemic therapy trial

MK-4280-003 : A Phase 1/Phase 2 Clinical Study to Evaluate the Safety and Efficacy of a Combination of...

This phase I/II trial is evaluating an immunotherapy combination (MK-4280 and Pembrolizumab) in patients with Hodgkin Lymphoma, Non-Hodgkin Lymphoma or B-Cell Lymphoma

Cancer type : Blood

Systemic therapy trial

M16-183 : Phase 1b Study of Venetoclax and Dinaciclib (MK7965) in Patients With Relapsed/Refractory...

This phase I trial is evaluating two drugs (one oral and one intravenous) in Acute Myeloid Leukaemia (AML) patients who have gotten worse or not responded to treatment

Cancer type : Acute Myeloid Leukaemia

Systemic therapy trial

ALLG MM19 : A Phase 3 trial of thalidomide-dexamethasone consolidation versus...

This phase III trial is evaluating a chemotherapy-steroid combination as maintenance therapy for transplant-eligible multiple myeloma (MM) patients who are undergoing single autologous stem cell transplantation (ASCT) as part of front-line therapy

Cancer type : Multiple Myeloma

Systemic therapy trial

IMAGO MF : A Multi-Center, Open Label Study to Assess the Safety, Steady-State Pharmacokinetics and...

This phase I trial is evaluating an oral drug (IMG-7289) in patients with Myelofibrosis

Cancer type : Myelofibrosis

Systemic therapy trial

CML12 DIRECT : A single arm phase II study to individualize dasatinib dosing based on trough levels and...

This phase II trial is evaluating oral dosing of the drug dasatinib in elderly patients with Chronic Myelogenous Leukaemia (CML)

Cancer type : Chronic Myelogenous Leukaemia

Systemic therapy trial

SADAL : Selinexor (KPT-330) in Patients With Relapsed/Refractory Diffuse Large B-Cell Lymphoma...

This phase II trial is using a new oral drug (selinexor) to treat patients with Diffuse Large B-Cell Lymphoma who have no other beneficial treatment options available

Cancer type : Blood

Systemic therapy trial

CARDINAL : A Phase 3, Pivotal, Open-label, Multicenter Study to Assess the Efficacy and Safety of...

This phase III trial is evaluating an investigational drug (Sutimlimab) in patients with Primary Cold Agglutinin disease, who have recently received a blood transfusion

Cancer type : Aplastic Anaemia

Systemic therapy trial

A Phase 2, Open-Label Study of Intratumoral Tavokinogene Telseplasmid Plus...

This phase II trial is evaluating a biological therapy (Tavokinogene Telseplasmid - delivered by electroporation), in combination with an immunotherapy drug (Pembrolizumab), in patients with advanced triple negative breast cancer

Cancer type : Breast

Systemic therapy trial

EX-TEM : Phase III Trial of Extended Temozolomide in Newly Diagnosed Glioblastoma

This phase III trial is trying to determine if extended post-radiation chemotherapy will improve survival outcomes in patients with newly diagnosed glioblastoma

Cancer type : Brain and Spinal

Systemic therapy trial

ICON9 : International Phase III Randomised Study to Evaluate the Efficacy of Maintenance Therapy...

This phase III trial is comparing maintenance therapy with two oral drugs (Olaparib and Cediranib), versus Olaparib as a maintenance therapy alone, in patients with relapsed ovarian cancer

Cancer type : Female Reproductive System

Systemic therapy trial

A Phase 1 Pharmacokinetic and Pharmacodynamic Study of TG-1701, an Irreversible Bruton's...

This phase I trial is evaluating the safety and effectiveness of a new oral drug (TG-1701) for patients with B-cell malignancies that have not responded or gotten worse with prior treatments

Cancer type : Blood

Systemic therapy trial

THOR : A Phase 3 Study of Erdafitinib Compared With Vinflunine or Docetaxel or Pembrolizumab in...

This phase III trial is evaluating an oral drug (Erdafitinib) for the treatment of advanced urothelial cancer, compared to standard treatment with chemotherapy or immunotherapy agents

Cancer type : Urinary System

Systemic therapy trial

CheckMate 9LA : A Phase 3, Randomized Study of Nivolumab Plus Ipilimumab in Combination With Chemotherapy...

This phase III trial is trying to determine whether treatment with immunotherapy (Nivolumab Plus Ipilimumab) and chemotherapy is better than chemotherapy alone in treating patients with Stage 4 Non-Small Cell (NSC) Lung Cancer

Cancer type : Non-Small Cell Lung Cancer

Systemic therapy trial

A Phase IB Open-label, Dose Escalation and Expansion Study to Investigate the Safety,...

This phase I trial is evaluating the drug GSK525762 in combination with androgen deprivation therapy and three other drugs (abiraterone, enzalutamide and prednisone) for the treatment of castrate-resistant prostate cancer (CRPC)

Cancer type : Prostate

Systemic therapy trial

APROC : A phase1b/2 Study Evaluating the Efficacy of APR-246, a First-in-class Agent Targeting...

This phase Ib/II trial is trying to determine whether the drug APR-246 and two chemotherapy drugs (5-FU and cisplatin) are safe and effective in the treatment of platinum resistant oesophageal cancer

Cancer type : Stomach

Systemic therapy trial

Spotlight : A Phase 3, Global, Multi-Center, Double-Blind, Randomized, Efficacy Study of Zolbetuximab...

This phase III trial is comparing treatment with an intravenous drug (Zolbetuximab) and chemotherapy (mFOLFOX6), versus chemotherapy alone, in patients with CLDN, HER2- advanced or metastatic gastric or gastroesophageal junction cancer

Cancer type : Stomach

Systemic therapy trial

Patina : A Randomized, Open Label, Phase III Trial to Evaluate the Efficacy and Safety of...

This phase III trial is trying to show the benefit of adding a chemotherapy drug (palbociclib) to anti-HER2 therapy plus endocrine therapy in the treatment of HER 2+ breast cancer that has spread to other parts of the body

Cancer type : Breast

Systemic therapy trial

A Phase 1 Clinical Trial of CEND-1 in Combination With Nabpaclitaxel and Gemcitabine in...

This phase I trial is testing a new drug (CEND-1) in combination with chemotherapy (Nabpaclitaxel and Gemcitabine) in patients with exocrine pancreatic cancers that have spread to other parts of the body

Cancer type : Pancreas

Systemic therapy trial

NILE : A Phase III, Randomized, Open-Label, Controlled, Multi-Center, Global Study of...

This phase III trial is assessing a first line treatment combining immunotherapy and chemotherapy, versus chemotherapy alone, in patients with locally advanced or metastatic urothelial cancer

Cancer type : Urinary System

Systemic therapy trial

ELARA : A Phase II, Single Arm, Multicenter Open Label Trial to Determine the Efficacy and Safety...

This phase II trial is testing a new biological therapy (tisagenlecleucel) that is made using a patient's T-Cells, to treat people who have been diagnosed with Follicular Lymphoma but have gotten worse or not responded to other therapies

Cancer type : Follicular Lymphoma

Systemic therapy trial

Resilient : A Randomized, Open Label Phase 3 Study of Irinotecan Liposome Injection (ONIVYDE®) Versus...

This phase II/III trial is comparing two intravenous drugs (Irinotecan liposome injection and Topotecan injection) in patients with small cell lung cancer who have gotten worse after first line therapy

Cancer type : Lung

Multiple treatment types

NUTMEG : A Randomised Phase II Study of NivolUmab and TeMozolomide vs Temozolomide alone in newly...

This phase II trial is comparing the effect of a chemotherapy drug (Temozolomide) alone and in combination with an immunotherapy drug (Nivolumab) for the treatment of elderly patients with a newly diagnosed glioblastoma

Cancer type : Brain and Spinal

Systemic therapy trial

DIAmOND : An investigator-initiated, non-randomised, phase II study of combination CTLA-4 and PD-L1...

This phase II trial is trying to determine whether combining an anti-HER2 therapy (trastuzumab) with two immunotherapy drugs (durvalumab and tremelimumab) will improve clinical outcomes for patients that are diagnosed with advanced HER2+ breast cancer

Cancer type : Breast

Multiple treatment types

Ave-Rec study : Phase II Trial PD-L1/PD-1 Blockade Avelumab (MSB0010718C) With Chemoradiotherapy for...

This phase II trial is evaluating the addition of an immunotherapy drug following long-course chemo-radiotherapy in patients with a locally advanced rectal cancer that is able to be surgically removed

Cancer type : Rectum

Systemic therapy trial

Efficacy of Epidermal Growth Factor Receptor (EGFR) inhibitor Panitumumab for the...

This phase II trial is evaluating a targeted cancer drug (Panitumumab) as a second line therapy for patients with advanced pancreatic ductal adenocarcinoma with wild-type KRAS mutation

Cancer type : Pancreas

Systemic therapy trial

INTEGRATE II : A Randomised Phase III Double-Blind Placebo-Controlled Study of Regorafenib in Refractory...

This phase III trial is testing the oral drug, regorafenib, for the treatment of refractory and advanced gastro-oesophageal cancers

Cancer type : Stomach

Systemic therapy trial

BEACON : A Multicenter, Randomized, Open-label, 3-Arm Phase 3 Study of Encorafenib + Cetuximab...

This phase III trial is comparing three orally administered chemotherapy drugs (encorafenib, binimetinib, cetuximab) with another treatment, as chosen by the investigator, for the treatment of metastatic colorectal cancer

Cancer type : Bowel

Multiple treatment types

VERTU : A Randomised Phase II study of veliparib and radiotherapy with adjuvant temozolomide and...

This phase II trial is evaluating the effectiveness of an anti-cancer drug (veliparib), radiotherapy and adjuvant (temozolomide) chemotherapy in patients with newly diagnosed Glioblastoma (GBM)

Cancer type : Glioma

Systemic therapy trial

NABNEC : A phase II study to establish if carboplatin and nab-paclitaxel combination is an...

This phase II trial is evaluating nab-paclitaxel in combination with carboplatin as a first line treatment for gastrointestinal neuroendocrine cancer

Cancer type : Stomach

Systemic therapy trial

DYNAMIC-II : Circulating tumour DNA (ctDNA) analysis informing adjuvant chemotherapy in Stage II Colon...

This study is looking at circulating DNA and how it could inform adjuvant chemotherapy for recurrence-free survival in patient with stage II colon cancer

Cancer type : Bowel

Systemic therapy trial

MONARCC : A randomised phase II study of Panitumumab monotherapy and panitumumab plus 5...

This phase II trial is trying to determine whether it is better to give a targeted therapy (Panitumumab) alone or in combination with standard chemotherapy (5-FU) as a primary treatment for advanced colorectal cancer

Cancer type : Bowel

Systemic therapy trial

VOYAGER : An International, Multicenter, Open-label, Randomized, Phase 3 Study of BLU-285 vs...

This phase III trial is comparing two oral drugs (BLU-285 vs Regorafenib) in patients who have been diagnosed with a Gastrointestinal Stromal Tumor (GIST) that has spread to other parts of the body

Cancer type : Stomach

Systemic therapy trial

Checkmate 577 : A Randomized, Multicenter, Double Blind, Phase III Study of Adjuvant Nivolumab or Placebo...

This phase III trial is trying to determine how effective nivolumab is in the treatment of surgically removed oesophageal and gastro-oesophageal junction cancers

Cancer type : Stomach

Systemic therapy trial

ASCOLT : Aspirin for Dukes C and High Risk Dukes B Colorectal Cancers - An International,...

This phase III trial is investigating asprin for Dukes C and high risk Dukes B colorectal cancers

Cancer type : Bowel

Systemic therapy trial

KEYPAD : Denosumab and Pembrolizumab in Clear Cell Renal Carcinoma: a Phase II Trial

This Phase II trial is evaluating the combination of an immunotherapy (Pembrolizumab) and a targeted therapy (Denosumab) for the treatment of advanced clear cell renal cell carcinoma (ccRCC)

Cancer type : Urinary System

Systemic therapy trial

CheckMate 9KD : A Phase 2 Study of Nivolumab in Combination With Either Rucaparib, Docetaxel, or...

This phase II trial is trying to determine the best drug (out of three drugs) to use in combination with Nivolumab (a type of immunotherapy) in the treatment of castration-resistant prostate cancer that has spread

Cancer type : Prostate

Multiple treatment types

ICE-PAC : A phase II study of Avelumab + stereotactic ablative body radiosurgery (SABR) for...

This phase II trial is assessing the combination of an immunotherapy drug (Avelumab) and stereotactic ablative body radiotherapy (SABR) for the treatment of castrate-resistant prostate cancer

Cancer type : Prostate

Systemic therapy trial

IPATential150 : A Phase III, Randomized, Double-Blind, Placebo-Controlled, Multicenter Trial Testing...

This phase III trial is trying to determine the effect of adding an investigational drug (Ipatasertib) to treatment with two other drugs (Abiraterone and Prednisone/Prednisolone) in patients with metastatic Castration-Resistant Prostate Cancer (mCRPC)

Cancer type : Prostate

Multiple treatment types

TheraP : A Randomised Phase 2 Trial of 177Lu-PSMA617 Theranostic Versus Cabazitaxel in Progressive...

This phase II trial is comparing a type of radionuclide therapy with a type of chemotherapy for the treatment of metastatic castration resistant prostate cancer that has advanced on other therapies

Cancer type : Prostate

Systemic therapy trial

A Phase 2, Open-label, 2-arm, Response Rate Study Of Talazoparib In Men With Dna Repair...

This phase II trial is evaluating an oral drug (Talazoparib) in men who have previously received treatment for metastatic Castration-Resistant Prostate Cancer (CRPC)

Cancer type : Prostate

Systemic therapy trial

UNISoN / ANZUP1602 : A Phase II Sequential Treatment Trial of Single Agent Nivolumab, Then Combination...

This Phase II trial is evaluating two new immunotherapy treatments (Nivolumab and Ipilimumab) for patients with metastatic Non-Clear Cell Renal Cell Carcinoma

Cancer type : Urinary System

Systemic therapy trial

FRACTION-RCC : A Phase 2, Real-time Assessment of Combination Therapies in Immuno-Oncology Study in...

This phase II trial is evaluating different combinations of therapies in patients with advanced renal cell carcinoma

Cancer type : Urinary System

Systemic therapy trial

Javelin Bladder 100 : A Phase 3, Multicenter, Multinational, Randomized, Open-label, Parallel-arm Study Of...

This phase III trial is comparing maintenance treatment with avelumab and best standard care, with best standard care alone, in patients with advanced urothelial cancer

Cancer type : Urinary System

Systemic therapy trial

OSCILLATE : Phase 2 trial to determine the efficacy, safety, and feasibility of alternating...

This phase II trial is alternating the use of two oral drugs (Osimertinib and Gefitinib) in patients with advanced EGFR-T790M positive Non-Small Cell (NSC) Lung Cancer

Cancer type : Lung

Systemic therapy trial

FRACTION-Lung : A Phase 2, Fast Real Time Assessment of Combination Therapies in Immuno-Oncology Study in...

This phase II trial is assessing four combination immunotherapies for the treatment of advanced Non-Small Cell (NSC) Lung Cancer

Cancer type : Lung

Systemic therapy trial

BR.31 : A Phase III Prospective Double Blind Placebo Controlled Randomized Study of Adjuvant...

This phase III trial is trying to determine whether it is better to receive a new drug (MEDI4736) after surgery for Lung Cancer, or if it is better to have no further treatment

Cancer type : Lung

Systemic therapy trial

CheckMate 651 : An Open Label, Randomized, Two Arm Phase III Study of Nivolumab in Combination With...

This phase III trial is comparing immunotherapy (with nivolumab and ipilimumab) with the 'extreme study regimen' as a first line treatment for patients with a squamous cell carcinoma of the head and neck that has come back or has spread to other parts of the body

Cancer type : Head and Neck

Systemic therapy trial

CT837 : A Phase 2, Randomized Study of MLN0128 (a Dual TORC1/2 Inhibitor), MLN0128+MLN1117 (a...

This phase II trial is trying to determine what effect adding an oral drug (MLN1028) to weekly paclitaxel will have in the treatment of advanced, recurrent or persistant Endometrial Cancer

Cancer type : Endometrium

Systemic therapy trial

ODONATE CONTESSA : Randomized, Phase 3 Study of Tesetaxel Plus a Reduced Dose of Capecitabine Versus...

This phase III trial is comparing two oral drugs (tesetaxel plus a reduced dose of capecitabine) with the approved dose of capecitabine alone in patients with hormone positive, HER 2- breast cancer

Cancer type : Breast

Radiotherapy trial

VERITAS : Vaginal Effects after Radiation Therapy in Anal Cancer Study (Other ID: U1111-1135-9316)

This trial is looking at the effects of vaginal dilator use, following pelvic radiotherapy for anal cancer

Cancer type : Anus

Systemic therapy trial

ATTAIN : A Phase 3 Open-Label, Randomized, Multicenter Study of NKTR-102 Versus Treatment of...

This phase III trial is comparing the drug NKTR-102 with a treatment chosen by the doctor in patients who have have been treated for breast cancer that has spread to the brain

Cancer type : Breast

Systemic therapy trial

KEYNOTE-755 : A Multicenter, Open-label, Randomized, Phase 3 Trial to Compare the Efficacy and Safety...

This phase III trial is comparing two immunotherapy drugs (pembrolizumab and lenvatinib) with a chemotherapy drug (either doxorubicin or paclitaxel, as chosen by the doctor) in the treatment of advanced endometrial cancer

Cancer type : Endometrium

Systemic therapy trial

Tiger : A Randomized Phase III Trial Comparing Conventional-Dose Chemotherapy Using Paclitaxel,...

This phase III trial is comparing conventional-dose chemotherapy (TIP regimen) with high-dose chemotherapy plus an autologous stem cell transplant (TI-CE regimen) as initial salvage treatment for patients with germ cell tumours that have gotten worse or not responded to prior therapies

Cancer type : Urinary System

Systemic therapy trial

A Phase 1b Open-Label Study Investigating the Safety and Pharmacokinetics of...

This phase Ib trial is assessing the safety of a new drug (blinatumomab) for the treatment of indolent Non-Hodgkin's Lymphoma that has gotten worse or not responded to prior therapy

Cancer type : Blood

Systemic therapy trial

oral AG-120 : A Phase 1b/2 Open-label, Randomized Study of 2 Combinations of Isocitrate Dehydrogenase...

This phase I/II trial is assessing azacitidine (a chemotherapy drug) with one of two oral drugs (AG-120 or AG-221) for the treatment of Acute Myeloid Leukaemia (AML)

Cancer type : Acute Myeloid Leukaemia

Systemic therapy trial

PRofound : A Phase III, Open Label, Randomized Study to Assess the Efficacy and Safety of Olaparib...

This phase III trial is evaluating the safety and efficacy olaparib, versus enzalutamide or abiraterone, in patients with metastatic prostate cancer who have failed prior treatment

Cancer type : Prostate

Systemic therapy trial

A Phase II Open-label, Randomized, Three-arm, Multicenter Study of LAG525 Given in...

This phase II trial is assessing different chemotherapy and immunotherapy drug combinations in patients with metastatic triple negative breast cancer (TNBC) who have received up to one line of prior therapy

Cancer type : Breast

Multiple treatment types

CHARIOT : Phase II Single Arm Study evaluating safety, feasibility and efficacy of Ipilimumab and...

This phase II trial is evaluating two immunotherapy drugs (Ipilimumab and Nivolumab) in combination with a weekly chemotherapy drug (Paclitaxel) for the treatment of Triple Negative Breast Cancer, followed by surgery and further Nivolumab treatment

Cancer type : Breast

Systemic therapy trial

A Phase 3, Randomized, Open-label Study of NKTR-214 Combined With Nivolumab Versus...

This phase III trial is trying to determine how well an investigational drug (NKTR-214) works when combined with an immunotherapy drug (Nivolumab) for the treatment of previously untreated melanoma skin cancer that is either unable to be surgically removed or has spread

Cancer type : Melanoma (Skin)

Systemic therapy trial

MATCH : Tabelecleucel for Allogeneic Hematopoietic Cell Transplant Subjects With EBV+ PTLD After...

This phase III trial is evaluating an immunotherapy (tabelecleucel) for the treatment of Epstein-Barr Virus-associated post-transplant lymphoproliferative disease in the setting of allogeneic hematopoietic cell transplant (HCT) after failure of rituximab

Cancer type : Lymphoma

Multiple treatment types

The RaDD study : Phase I Dose Escalation Study of Radiotherapy and Durvalumab in Relapsed/Refractory...

This phase I trial is assessing simultaneous radiotherapy and immunotherapy (with durvalumab) in patients with relapsed Diffuse Large B Cell Lymphoma

Cancer type : Blood

Systemic therapy trial

ATHENA : A Multicenter, Randomized, Double-Blind, Placebo- Controlled Phase 3 Study in Ovarian...

This phase III trial is evaluating an oral drug (Rucaparib) and an intravenous immunotherapy drug (Nivolumab) as maintenance therapy for newly diagnosed ovarian cancer patients

Cancer type : Female Reproductive System

Systemic therapy trial

ALLG MM18 : Single Arm, Multicentre Study of Carfilzomib in Combination With Thalidomide and...

This phase II trial is combining the drug Carfilzomib with an immunotherapy agent (Thalidomide) and a steroid (Dexamethasone) in patients with relapsed or refractory Multiple Myeloma

Cancer type : Multiple Myeloma

Systemic therapy trial

Phase 1A/1B Dose Escalation and Expansion Study of SBP-101 in Combination With...

This phase I trial is combining a new drug (SBP-101, delivered as an injection) with two chemotherapy drugs (nab-paclitaxel and Gemcitabine) in patients with previously untreated pancreatic cancers that have spread to other parts of the body

Cancer type : Pancreas

Systemic therapy trial

POLARIX : A Phase III, Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial Comparing...

This phase III trial is comparing the addition of an investigational drug (polatuzumab vedotin) to R-CHP and R-CHOP chemotherapy in patients with previously untreated diffuse large B-cell lymphoma (DLBCL)

Cancer type : Blood

Systemic therapy trial

POSNOC : POsitive Sentinel NOde: Adjuvant Therapy Alone Versus Adjuvant Therapy Plus Clearance or...

This trial is comparing the effect of having adjuvant therapy on its own, or in combination with axillary treatment, in women with metastatic breast cancer

Cancer type : Breast

Systemic therapy trial

CT811 : A Phase 3 Placebo-Controlled Study of Carboplatin/Paclitaxel With or Without Concurrent...

This phase III trial is evaluating the use of an anti-cancer drug (veliparib) in women with previously untreated, stage III or IV high-grade serous Epithelial Ovarian, Fallopian Tube, or Primary Peritoneal Cancer

Cancer type : Female Reproductive System

Systemic therapy trial

CHARLI : A Phase Ib/II Trial of Ipilimumab-Nivolumab-Denosumab and Nivolumab-Denosumab in Patients...

This phase I/II trial is evaluating the addition of a new treatment (Denosumab) to standard immunotherapies for patients with metastatic melanoma

Cancer type : Melanoma (Skin)

Systemic therapy trial

EpiBrentlen : Brentuximab Vedotin and Lenalidomide in Patients With Relapsed/ Refractory T-cell...

This phase I trial is evaluating the combination of two drugs (Brentuximab vedotin and lenalidomide) for the treatment of relapsed/refractory T-cell lymphoma or Hodgkin Lymphoma

Cancer type : Blood

Systemic therapy trial

CADENZA : A Phase 3, Randomized, Double-blind, Placebo-controlled Study to Assess the Efficacy and...

This phase III trial is evaluating an investigational drug (Sutimlimab) in patients with primary cold agglutinin disease without a recent history of blood transfusion

Cancer type : Aplastic Anaemia

Systemic therapy trial

KEYNOTE-555 : Relative Bioavailability Study of Subcutaneous Injection Versus Intravenous Infusion of...

This phase I trial is assessing the safety of administering a drug (pembrolizumab) by injection beneath the skin for the treatment of advanced melanoma

Cancer type : Melanoma (Skin)

Multiple treatment types

KEYNOTE-799 : A Trial of Pembrolizumab in Combination With Chemotherapy and Radiotherapy in Stage III...

This phase II trial is testing a drug (pembrolizumab) in combination with chemotherapy and radiotherapy for the treatment of locally advanced Stage III non-small cell lung cancer that cannot be removed by surgery

Cancer type : Lung

Systemic therapy trial

CANTATA : A Randomized, Double-Blind, Placebo-Controlled Phase 2 Study Comparing CB-839 in...

This phase II trial is evaluating a new oral drug (CB-839) in combination with cabozantinib (a different oral drug), compared to cabozantinib alone in patients with advanced or metastatic renal cell carcinoma

Cancer type : Urinary System

Systemic therapy trial

DYNAMIC-III : Circulating Tumour DNA Analysis Informing Adjuvant Chemotherapy in Stage III Colon...

This phase II/III trial is evaluating the process of using ctDNA (tumour-derived DNA) results as a way to tailor treatment (in this case chemotherapy) in patients with stage III colon cancer

Cancer type : Bowel

Systemic therapy trial

MODULATE : Modulation Of The Tumour Microenvironment Using Either Vascular Disrupting Agents or...

This phase II trial is evaluating the combination of nivolumab (an immunotherapy drug) and two other drugs (BNC105 or BBI608) in patients with colorectal cancers that have spread to other parts of the body and have failed prior therapies

Cancer type : Bowel

Systemic therapy trial

KEYNOTE-789 : A Randomized, Double-Blind, Phase 3 Study of Pemetrexed + Platinum Chemotherapy with or...

This phase III trial is evaluating a chemotherapy combination (pemetrexed combined with carboplatin or cisplatin) with and without the drug KEYTRUDA® (pembrolizumab) for the treatment of metastatic non-squamous non-small cell lung cancer (NSCLC)

Cancer type : Lung

Systemic therapy trial

Phase II Open-label Global Study to Evaluate the Effect of Dabrafenib in Combination With...

This phase II trial is investigating the activity of two oral drugs (dabrafenib and trametinib) in children and adolescents who have BRAF V600 mutation positive low grade glioma or relapsed or refractory high grade glioma

Cancer type : Brain and Spinal

Systemic therapy trial

SCOUT : A Phase 1/2 Study of the Oral TRK Inhibitor LOXO-101 (Larotrectinib) in Pediatric...

This phase I/II trial is using an oral drug (LOXO-101) as a treatment in children and adolescents with central nervous system tumours

Cancer type : Central Nervous System

Systemic therapy trial

KB004 : A Phase I Safety and Bioimaging Trial of KB004 in Patients With Glioblastoma

This phase I trial is testing a new drug (KB004) in patients with recurrent glioblastoma

Cancer type : Brain and Spinal

Systemic therapy trial

M15-531 : A Randomized Phase 2 Study Evaluating the Safety, Pharmacokinetics and Efficacy of...

This phase II trial is evaluating Azacitidine alone and in combination with Venetoclax in patients with previously untreated Myelodysplastic Syndromes (MDS)

Cancer type : Myelodysplasia

Systemic therapy trial

Morpheus-CRC : A Phase Ib/II, Open-Label, Multicenter, Randomized Umbrella Study Evaluating The Efficacy...

This phase Ib/II trial is evaluating different combinations of immunotherapy-based treatments in patients with metastatic colorectal cancer that has not responded or gotten worse on other treatments

Cancer type : Bowel

Systemic therapy trial

IMmotion010 : A Phase III, Multicenter, Randomized, Placebo-Controlled, Double-Blind Study of...

This phase III trial is assessing atezolizumab (an immunotherapy) as an adjuvant therapy in patients whose renal cell carcinoma is at high risk of recurrence following surgery

Cancer type : Renal cell carcinoma

Multiple treatment types

P_LUNG GP : A Randomised Phase III Trial of High Dose Palliative Radiotherapy (HDPRT) Versus...

This phase III trial is comparing a high dose of palliative radiotherapy alone and in combination with concurrent chemotherapy in patients with metastatic Non-Small Cell (NSC) Lung Cancer

Cancer type : Lung

Treatment trial

ctDNA-06 : Evaluation of RAS mutations in cell free deoxyribonucleic acid (cfDNA) in response to...

Cancer type : Bowel

Systemic therapy trial

CanStem303C : A Phase III Study of BBI-608 in Combination With 5-Fluorouracil, Leucovorin, Irinotecan...

This phase III trial is testing a drug called BBI-608 in combination with other drugs, for patients with previously treated metastatic colorectal cancer (CRC)

Cancer type : Bowel

Systemic therapy trial

Dynamic-Rectal : Circulating Tumour DNA Analysis Informing Adjuvant Chemotherapy in Locally Advanced...

This trial is evaluating the process of using tumour-derived DNA (ctDNA) results as a way of tailoring treatment (in this case, chemotherapy) for patients with locally advanced rectal cancer

Cancer type : Rectum

Systemic therapy trial

JAVELIN Lung 100 : A Phase III, Open-label, Multicenter Trial of Avelumab (MSB0010718C) Versus...

This phase III trial is comparing the drug, avelumab, with platinum-based doublet chemotherapy in Non-Small Cell (NSC) Lung Cancer patients with PD-L1+ tumours

Cancer type : Lung

Systemic therapy trial

EXAMINER : A Randomized, Double-blind Study To Evaluate the Efficacy and Safety of Cabozantinib...

This phase IV trial is assessing two doses (60mg and 140mg) of an oral drug (cabozantinib) in the treatment of progressive, metastatic Medullary Thyroid Cancer (MTC)

Cancer type : Thyroid

Systemic therapy trial

STELLAR : A phase 2, open label trial to evaluate safety, tolerability and efficacy of...

This phase II trial is evaluating a new drug (guadecitabine) in patients with T-Cell Lymphoma

Cancer type : T-Cell Lymphoma

Systemic therapy trial

ECHELON-2 : A Randomized, Double-blind, Placebo-controlled, Phase 3 Study of Brentuximab Vedotin and...

This phase III trial is comparing Brentuximab Vedotin and CHP chemotherapy, with standard chemotherapy, for the treatment of mature T-Cell Lymphoma

Cancer type : T-Cell Lymphoma

Systemic therapy trial

A Clinical Study to Demonstrate Safety and Efficacy of E7777 (Denileukin Diftitox) in...

This phase III trial is evaluating E7777 as an intravenous treatment for patients with persistant and recurrent Cutaneous T-cell Lymphoma

Cancer type : T-Cell Lymphoma

Systemic therapy trial

FRACTION-GC : A Phase 2, Fast Real-time Assessment of Combination Therapies in Immuno-ONcology Study in...

This Phase II trial is trying to determine the most effective combination therapy for the immunotherapy drug Nivolumab in patients with advanced gastric cancer

Cancer type : Stomach

Multiple treatment types

TOP GEAR : A randomised phase II/III trial of preoperative chemoradiotherapy versus preoperative...

This phase II/III trial is comparing preoperative chemradiotherapy with preoperative chemotherapy for patients with resectable gastric cancer

Cancer type : Stomach

Systemic therapy trial

CT777 : A Phase 3 Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and...

This phase III trial is assessing the addition of andecaliximab to a combination chemotherapy as a first line treatment for people with advanced gastric or gastro-oesophageal cancers

Cancer type : Stomach

Systemic therapy trial

TAHOE : A Randomized, Open-label, Multicenter, Phase 3 Study of Rovalpituzumab Tesirine Compared...

This phase III trial is comparing two drugs (Rovalpituzumab Tesirine and Topotecan) in patients with advanced or metastatic Small Cell Lung Cancer (SCLC) that has gotten worse following front-line chemotherapy

Cancer type : Small Cell Lung Cancer

Systemic therapy trial

A Phase 2 Open-label Extension Study for Subjects With Prostate Cancer Who Previously...

This phase II trial is collecting long term data about patients with prostate cancer, who previously participated in an enzalutamide clinical trial

Cancer type : Prostate

Radiotherapy trial

LuPSMA Trial : For men with metastatic prostate cancer refractory to hormonal and chemotherapy, what is...

This phase II trial is evaluating a targeted radiotherapy in men with an advanced prostate cancer that has spread to other parts of the body and is not responding to systemic treatment

Cancer type : Prostate

Systemic therapy trial

HERO : A Multinational Phase 3 Randomized, Open-label, Parallel Group Study to Evaluate the...

This phase III trial is evaluating an oral drug (Relugolix) in the treatment of advanced prostate cancer

Cancer type : Prostate

Systemic therapy trial

ATRIDIA SHR3680-002 : A Phase 1 Trial of SHR3680 in Subjects With Metastatic Castration-Resistant Prostate...

This phase I trial is testing a new oral drug (SHR3680) in patients with metastatic Castration Resistant Prostate Cancer (mCRPC)

Cancer type : Prostate

Systemic therapy trial

TRITON3 : A Multicenter, Randomized, Open Label Phase 3 Study of Rucaparib Versus Physician's...

This phase III trial is comparing an oral drug (Rucaparib) with standard treatment in patients who have metastatic castration-resistant prostate cancer

Cancer type : Prostate

Systemic therapy trial

TRITON2 : A Multicenter, Open-label Phase 2 Study of Rucaparib in Patients With Metastatic...

This phase II trial is evaluating the effect of the anti-cancer drug Rucaparib in patients with metastatic castration-resistant prostate cancer

Cancer type : Prostate

Systemic therapy trial

GALAHAD : A Phase 2 Efficacy and Safety Study of Niraparib in Men With Metastatic...

This phase II study is assessing the safety and efficacy of niraparib (an oral drug) in men with metastatic castrate resistant prostate cancer and DNA rapair anomolies

Cancer type : Prostate

Surgical trial

Irreversible Electroporation : The safety and efficacy of Irreversible Electroporation for the ablation of prostate...

This trial is assessing the safety and efficacy of Irreversible Electroporation for the removal of prostate cancer

Cancer type : Prostate

Systemic therapy trial

NP39761 : A Phase II, Single-Arm, Open-Label Study to Evaluate the Efficacy, Safety,...

This Phase II trial is evaluating an oral drug (Idasanutlin), on its own, in patients with Hydroxyurea-Resistant/Intolerant Polycythemia Vera

Cancer type : Polycythaemia vera

Multiple treatment types

COMPETE : A Prospective, Randomised, Controlled, Open-label, Multicentre Phase III Study to...

This phase III trial is comparing two molecular therapies in patients with neuroendocrine tumours of stomach, intestinal or pancreatic origin

Cancer type : Stomach

Multiple treatment types

CONTROL NETS : Capecitabine ON Temozolomide Radionuclide Therapy Octreotate Lutetium-177 NeuroEndocrine...

This phase II trial is evaluating a radionuclide therapy and a chemotherapy, alone and in combination, for the treatment of gastro neuroendocrine tumours

Cancer type : Stomach

Systemic therapy trial

Met Pancreatic : Randomized Study of AM0010 in Combination With FOLFOX Compared to FOLFOX Alone as...

This phase III trial is comparing the effectiveness of FOLFOX (drug) alone and in combination with AM0010 (a biologic therapy) for the treatment of metastatic pancreatic cancer

Cancer type : Pancreas

Systemic therapy trial

CanStem111P : A Phase III Study of BBI-608 Plus Nab-Paclitaxel With Gemcitabine in Adult Patients With...

This phase III trial is evaluating a new inhibitor drug (BBI-608) with two anti-cancer chemotherapy drugs (nab-paclitaxel and gemcitabine) in patients with metastatic pancreatic cancer

Cancer type : Pancreas

Systemic therapy trial

CheckMate 649 : A Randomized, Multicenter, Open-Label, Phase 3 Study of Nivolumab Plus Ipilimumab or...

This phase III trial trying to compare the relative survival of patients who receive either (i) nivolumab and ipilimumab (ii) nivolumab and chemotherapy or (iii) chemotherapy alone for the treatment of oesophageal and gastro-oesophageal junction cancers

Cancer type : Stomach

Systemic therapy trial

KEYNOTE-181 : A Phase III Randomized Open-label Study of Single Agent Pembrolizumab vs Physicians'...

This phase III trial is comparing pembrolizumab (an immunotherapy agent) with standard therapy for patients with advanced oesophageal and gastro-oesophageal junction cancers that have gotten worse after first line treatment

Cancer type : Stomach

Systemic therapy trial

KEYNOTE-590 : A Randomized, Double-Blind, Placebo-Controlled Phase III Clinical Trial of Pembrolizumab...

This Phase III trial is evaluating an immunotherapy drug (Pembrolizumab) and a combination chemotherapy (5-fluorouracil, given alone or in combination with Pemrolizumab) for the treatment of advanced oesophageal cancer

Cancer type : Oesophagus

Systemic therapy trial

IMpower030 : A Phase III, Double-Blinded, Multicenter, Randomized Study Evaluating the Efficacy and...

This phase III trial is evaluating neoadjuvant treatment with atezolizumab and a type of chemotherapy in patients with Stage II, IIIA, or select IIIB non−small cell (NSC) lung cancer that is able to be surgically removed

Cancer type : Non-Small Cell Lung Cancer

Multiple treatment types

NIVORAD : A randomised phase 2 trial of nivolumab and stereotactic ablative body radiotherapy in...

This phase II trial is evaluating an immunotherapy (Nivolumab) and stereotactic ablative body radiotherapy in patients with advanced Non-Small Cell (NSC) Lung Cancer whose cancer has gotten worse following chemotherapy treatment

Cancer type : Non-Small Cell Lung Cancer

Systemic therapy trial

M15-522-MDS : A Phase 1b Study Evaluating the Safety and Pharmacokinetics of Venetoclax as a...

This phase I trial is evaluating an oral drug (Venetoclax) alone and in combination with a chemotherapy drug (Azacitidine - given by injection) in patients with higher-risk Myelodysplastic Syndromes (MDS)

Cancer type : Myelodysplasia

Systemic therapy trial

ONCONOVA 04-30 : A Phase III, International, Randomized, Controlled Study of Rigosertib Versus Physician's...

This phase III trial is comparing a standard therapy with the investigational agent (Rigosertib) for the treatment of Myelodysplastic Syndrome

Cancer type : Myelodysplasia

Systemic therapy trial

A Phase 1/2 Study to Evaluate Safety, Pharmacokinetics and Efficacy of Isatuximab in...

This phase I/II trial is evaluating a combination of two intravenous drugs (Isatuximab and Cemiplimab) for patients with multiple myeloma that has gotten worse or not responded to prior treatment

Cancer type : Multiple Myeloma

Systemic therapy trial

AQUILA : A Phase 3 Randomized, Multicenter Study of Subcutaneous Daratumumab Versus Active...

This phase III trial is trying to determine whether treatment with an anti-cancer drug (daratumumab) is more effective than active monitoring in patients with high-risk smoldering multiple myeloma (SMM)

Cancer type : Multiple Myeloma

Systemic therapy trial

INTREPID-1 : A Phase 1b Study Evaluating the Safety, Tolerability, Pharmacokinetics and Efficacy of...

This phase I trial is evaluating two different types of an oral drug (oprozomib) in combination with dexamethasone (a steroid) and pomalidomide for the treatment of multiple myeloma

Cancer type : Multiple Myeloma

Systemic therapy trial

Takeda C16029 (RRMM) : A Phase 2/3, Randomized, Open-Label Study Comparing Oral Ixazomib/Dexamethasone and Oral...

This phase II/III trial is comparing two oral drugs (ixazomib and pomalidomide) both given in combination with a steroid (dexamethasone) in the treatment of Multiple Myeloma

Cancer type : Multiple Myeloma

Systemic therapy trial

ROCHE NP39403 (BET Inhibitor) : Open-label, Multicenter, Dose-escalation/Expansion Phase Ib Study to Evaluate Safety,...

This phase I trial is trying to determine whether it is better to give a new drug (RO6870810) alone or in combination with a different anti-cancer drug (daratumumab) when treating patients with advanced Multiple Myeloma

Cancer type : Multiple Myeloma

Systemic therapy trial

A Phase 3 Randomized, Multicenter Study of Subcutaneous vs. Intravenous Administration of...

This phase III trial is trying to determine the best way of delivering a drug in patients who have Multiple Myeloma

Cancer type : Multiple Myeloma

Systemic therapy trial

An Open-Label, Multicenter, Phase I Trial Evaluating the Safety and Pharmacokinetics of...

This phase I trial is evaluating an intravenous drug (BFCR4350A) in patients with multiple myeloma, who have progressed or not responded to prior treatment

Cancer type : Multiple Myeloma

Systemic therapy trial

IMROZ : A Phase 3 Randomized, Open-label, Multicenter Study Assessing the Clinical Benefit of...

This phase III trial is evaluating the addition of the drug Isatuximab (SAR650984) to chemotherapy treatment (with Bortezomib (Velcade), Lenalidomide (Revlimid) and Dexamethasone) in newly diagnosed patients with Multiple Myeloma

Cancer type : Multiple Myeloma

Systemic therapy trial

A Phase 1 Open-label Study Evaluating the Safety, Tolerability, Pharmacokinetics,...

This phase I trial will be comparing different doses of the drug AMG 701 in patients with Multiple Myeloma

Cancer type : Multiple Myeloma

Systemic therapy trial

AMaRC 03-16 : A Randomised phase 2 study of bortezomib, cyclophosphamide and dexamethasone induction...

This phase II trial is assessing an induction therapy (VCD) alone and with daratumumab maintenance (VCDD) as a treatment alternative for Multiple Myeloma patients who are unable to receive a transplant

Cancer type : Multiple Myeloma

Systemic therapy trial

ALLG MM20 : A Multicentre Phase 3 Trial Comparing...

This phase III trial is combining elotuzumab with three other drugs (cyclophosphamide, thalidomide and dexamethasone ) for the treatment of Multiple Myeloma

Cancer type : Multiple Myeloma

Systemic therapy trial

NMP : A Phase I, Open Label Dose Escalation Trial of Orally Administered N-methyl-pyrrolidone...

This phase I trial is evaluating an oral drug (N-methyl-pyrrolidone) in patients with relapsed Myeloma

Cancer type : Multiple Myeloma

Systemic therapy trial

KappaMab : A Phase IIb, open label, sequential cohort study comparing KappaMab alone to KappaMab in...

This phase II trial is evaluating an investigational antibody therapy (KappaMab) in combination with lenalidomide (a chemotherapy drug) and dexamethasone (a steroid) for the treatment of relapsed Multiple Myeloma

Cancer type : Multiple Myeloma

Systemic therapy trial

ROAR : A Phase Ib trial of oral azacitidine in combination with lenalidomide and dexamethasone...

This phase I trial is combining the oral drug azacitidine, with lenalidomide (a chemotherapy drug) and dexamethasone (a steroid) for the treatment of Multpile Myeloma

Cancer type : Multiple Myeloma

Radiotherapy trial

ROAM : Radiation versus Observation following surgical resection of Atypical Meningioma: a...

This trial is trying to determine how effective adjuvant fractionated radiotherapy is, in treating newly diagnosed atypical meningioma, in comparison to active monitoring

Cancer type : Meningioma

Systemic therapy trial

A Phase Ib Study Evaluating Cobimetinib Plus Atezolizumab in Patients With Advanced BRAF...

This phase I trial is evaluating an oral drug (Cobimetinib) and an immunotherapy agent (Atezolizumab) in combination for the treatment of BRAF V600-wild type (WT) melanoma that has spread or is unable to be surgically removed

Cancer type : Melanoma (Skin)

Systemic therapy trial

ILLUMINATE-301 : A Randomized Phase 3 Comparison of IMO-2125 With Ipilimumab Versus Ipilimumab Alone in...

This phase III trial is comparing the effectiveness of an immunotherapy drug (Ipilimumab) with and without an injection of IMO-2125 within the tumour of patients who have advanced melanoma that has gotten worse on prior immunotherapy treatment

Cancer type : Melanoma (Skin)

Systemic therapy trial

PISCES : A Multicenter Phase 2, Open-Label Trial of Intratumoral pIL-12 Plus Electroporation in...

This Phase II trial is evaluating an intratumoral therapy (within a tumor) and electroporation (a microbiology technique that applies an electric field to cells in the body) in combination with an immunotherapy agent (Pembrolizumab) in patients with advanced stage II/IV melanoma

Cancer type : Melanoma (Skin)

Systemic therapy trial

A Randomized, Double-blind, Placebo-controlled, Phase III Study Comparing the Combination...

This phase III trial is evaluating the addition of PDR001 biological therapy to two chemotherapy drugs (Dabrafenib and Trametinib) in patients with previously untreated metastatic BRAF V600 mutant melanoma

Cancer type : Melanoma (Skin)

Systemic therapy trial

KEYNOTE-022 : A Phase I/II Study to Assess the Safety and Efficacy of MK-3475 in Combination With...

This phase I/II trial is evaluating the combination of an immunotherapy drug (Pembrolizumab) and two chemotherapy drugs (Dabrafenib and Trametinib) for the treatment of advanced Melanoma

Cancer type : Melanoma (Skin)

Systemic therapy trial

TACTI-mel : A Multicentre, Open Label, Dose Escalation, Phase 1 Study in Patients With Unresectable...

This phase I trial is trying to determine the recommended dose of a new drug (IMP321) when given in combination with an immunotherapy agent (pembrolizumab) for people with metastatic melanoma

Cancer type : Melanoma (Skin)

Systemic therapy trial

Keynote-252 : A Phase 3 Randomized, Double-Blind, Placebo-Controlled Study of Pembrolizumab (MK-3475)...

This phase III trial is comparing pembrolizumab (immunotherapy) alone and in combination with epacadostat (an oral drug) for people with metastatic melanoma

Cancer type : Melanoma (Skin)

Radiotherapy trial

TROG 08.05 : Whole brain radiotherapy following local treatment of intracranial metastases of...

This phase III trial is assessing whole brain radiotherapy following local treatment for people with melanoma spread to the brain

Cancer type : Melanoma (Skin)

Systemic therapy trial

A Phase II Randomized, Open-label, Multi-center Study of the Safety and Efficacy of...

This phase II trial is comparing a new biological therapy (IMCgp100) with a chemotherapy drug (dacarbazine) and two immunotherapy drugs (ipilimumab or pembrolizumab) in patients with Uveal Melanoma

Cancer type : Melanoma (Ocular)

Radiotherapy trial

FSRT (EYE STUDY) : Can reduced dose radiotherapy delivered in standard fractionation improve the therapeutic...

This phase 0 trial is trying to determine the effect of adding radiotherapy to stereotactic treatment for patients with choroidal melanoma

Cancer type : Melanoma (Ocular)

Multiple treatment types

Yttrium-90 : A pilot study of combined modality treatment for hepatic metastases of uveal melanoma...

This phase I trial is combining radiation therapy and chemotherapy for patients with Uveal Melanoma (a cancer of the eye) that has spread to the liver

Cancer type : Melanoma (Ocular)

Multiple treatment types

SJMB12 : A Clinical and Molecular Risk-Directed Therapy for Newly Diagnosed Medulloblastoma (Other...

This phase II trial will assess the effectiveness of different Medullablastoma treatments in patients, according to their clinical risk and molecular subtype

Cancer type : Medullablastoma

Systemic therapy trial

SYMPATICO : Phase 3 Study of Ibrutinib in Combination With Venetoclax in Subjects With Mantle Cell...

This phase III trial is combining two oral drugs (Ibrutinib and Venetoclax) for the treatment of Mantle Cell Lymphoma

Cancer type : Mantle Cell Lymphoma

Systemic therapy trial

ACE-LY-308 : A Phase 3, Randomized, Double-blind, Placebo-controlled, Multicenter Study of...

This phase III trial is evaluating an oral drug (acalabrutinib) in combination with two other drugs (bendamustine and rituximab) for the treatment of Mantle Cell Lymphoma

Cancer type : Mantle Cell Lymphoma

Systemic therapy trial

AIM study : A Phase 2 Study of ABT-199 in Combination With Ibrutinib in the Treatment of Patients...

This phase II trial is assessing the combination of two drugs (ABT-199 and irutinib) for the treatment of Mantle Cell Lymphoma

Cancer type : Mantle Cell Lymphoma

Systemic therapy trial

MERU : A Randomized, Double-Blind, Placebo-Controlled Phase 3 Study of Rovalpituzumab Tesirine...

This phase III trial is evaluating an experimental drug (Rovalpituzumab tesirine) as a maintenance therapy in patients with extensive stage small cell lung cancer

Cancer type : Lung

Systemic therapy trial

M14-361 : A Phase 1 Dose Escalation and Phase 2 Randomized Double-Blind Study of Veliparib in...

This phase I trial is combining an anti-cancer drug (veliparib) with chemotherapy (carboplatin and etoposide) for the treatment of patients with extensive-stage Small Cell Lung Cancer (SCLC)

Cancer type : Lung

Systemic therapy trial

A Phase III, Open-Label, Randomized Study to Evaluate the Efficacy and Safety of Adjuvant...

This phase III trial is comparing an oral drug (Alectnib) and platinum based chemotherapy for the treatment of ALK+ Non-Small Cell (NSC) Lung Cancer

Cancer type : Lung

Multiple treatment types

STABLE-MATES : A Randomised Phase III study of sub-lobar resection (SR) versus Stereotactic Ablative...

This phase III trial is comparing surgery and radiation therapy in the treatment of stage I Non-Small Cell (NSC) Lung Cancer

Cancer type : Lung

Systemic therapy trial

A Phase I/II, Open-Label, Multicentre Study to Investigate the Safety, Tolerability,...

This phase I/II trial is testing a new drug (AZD4205) alone and in combination with an oral drug (Osimertinib) in patients with advanced Non-Small Cell (NSC) Lung Cancer who progressed on prior treatment

Cancer type : Lung

Multiple treatment types

SABRseq : Sequencing of Stereotactic Ablative Body Radiotherapy in Combination With PD-1 Blockade...

This Phase Ib trial is evaluating the safety and effect of giving pembrolizumab (commonly used as an immunotherapy drug), to patients with metastatic non-small cell (NSC) lung cancer, before or after radiotherapy treatment

Cancer type : Lung

Systemic therapy trial

KEYNOTE-598 : A Phase 3, Randomized, Double-Blind Study of Pembrolizumab Plus Ipilimumab vs...

This phase III trial is evaluating pembrolizumab (an immunotherapy drug) on its own and in combination with ipilimumab (a different immunotherapy drug) in patients with metastatic non-small cell (NSC) lung cancer

Cancer type : Lung

Systemic therapy trial

Morpheus Lung : A Phase Ib/II, Open-Label, Multicenter, Randomized Umbrella Study Evaluating The Efficacy...

This phase I/II trial is evaluating combinations of different immunotherapy-based treatments in patients with metastatic non-small cell (NSC) lung cancer

Cancer type : Lung

Systemic therapy trial

BFAST : A Phase II/III Multicenter Study Evaluating the Efficacy and Safety of Multiple Targeted...

This phase II/III trial is evaluating different targeted therapy and immunotherapy treatments in patients with advanced or metastatic Non-Small Cell (NSC) Lung Cancer

Cancer type : Lung

Systemic therapy trial

PEARLS : A Randomized, Phase 3 Trial With Anti-PD-1 Monoclonal Antibody Pembrolizumab (MK-3475)...

This phase III trial is evaluating an immunotherapy drug (Pembrolizumab) as an additional therapy in patients with Non Small Cell (NSC) Lung Cancer following surgery and the completion of a standard adjuvant therapy

Cancer type : Lung

Systemic therapy trial

A Phase Ib, Open-label, Multicenter Study of Oral LXH254 in Combination With Oral LTT462...

This phase I trial is comparing two oral drugs (LXH254 and LTT462) in patients with metastatic (KRAS or BRAF) Non-Small Cell (NSC) Lung Cancer

Cancer type : Lung

Systemic therapy trial

CAVATAK : A phase I/II open-label trial of intravenous CAVATAKTM in combination with Pembrolizumab...

This phase I trial is combining a biological therapy (CAVATAK/CVA21) and an immunotherapy (Pembrolizumab) for the treatment of advanced Non-Small Cell (NSC) Lung Cancer

Cancer type : Lung

Systemic therapy trial

CheckMate 384 : A Dose Frequency Optimization, Phase IIIB/IV Trial of Nivolumab 240 mg Every 2 Weeks vs...

This phase III trial is trying to determine the most effective dose of nivolumab to use in the treatment of advanced Non Small Cell Lung Cancer (NSCLC)

Cancer type : Lung

Systemic therapy trial

IMpower 132 : A Phase III, Open-Label, Randomized Study of Atezolizumab (MPDL3280A, Anti-Pd-L1...

This phase III trial is comparing Atezolizumab (an immunotherapy drug) in combination with Cisplatin and Pemetrexed (combination chemotherapy), with Cisplatin and Pemetrexed on its own, in patients with stage IV Non-Small Cell (NSC) Lung Cancer

Cancer type : Lung

Systemic therapy trial

Dublin 3 : Randomized Blinded Phase III Assessment of Second or Third-Line Chemotherapy With...

This phase III trial is comparing outcomes for patients with Non-Small Cell (NSC) Lung Cancer, who are receiving second- or third- line chemotherapy with docetaxel alone and in combination with plinabulin, for advanced stage or metastatic disease

Cancer type : Lung

Systemic therapy trial

LDK378 : A Multi-center, Open-label Study to Assess the Safety and Efficacy of Combination...

This phase I trial is trying to determine the safety and effectiveness of two drugs (Ceritinib and Nivolumab), in the treatment of ALK + Non-Small Cell (NSC) Lung Cancer

Cancer type : Lung

Systemic therapy trial

KEYNOTE-407 : A Randomized, Double-Blind, Phase III Study of Carboplatin-Paclitaxel/Nab-Paclitaxel...

This phase III trial is testing carboplatin and paclitaxel (or nab-paclitaxel) alone and in combination with pembrolizumab for the treatment of Non-Small Cell (NSC) Lung Cancer, in adults, that has spread to other parts of the body

Cancer type : Lung

Systemic therapy trial

PEARL : A Phase III Randomized, Open-Label, Multi-Center, Global Study of Durvalumab Versus...

This phase III trial is evaluating the safety of an immunotherapy drug (Durvalumab) and platinum based SoC chemotherapy as a first line treatment for patients with Non-Small Cell (NSC) Lung Cancer

Cancer type : Lung

Systemic therapy trial

ADAURA : A Phase III, Double-blind, Randomized, Placebo-controlled Multi-centre, Study to Assess...

This phase III trial is assessing the safety and effictiveness of the drug, AZD9291, in patients with EGFR positive Non-Small Cell (NSC) Lung Cancer

Cancer type : Lung

Systemic therapy trial

SHERLOC : A Phase 2 Study of MM-121 in Combination With Docetaxel or Pemetrexed Versus Docetaxel or...

This phase II trial is trying to determine whether adding a drug (MM-121) to treatment with Docetaxel or Pemetrexed is more effective than using either drug, alone, in patients with heregulin-positive Non-Small Cell (NSC) Lung Cancer

Cancer type : Lung

Systemic therapy trial

IMbrave150 : A Phase III, Open-Label, Randomized Study of Atezolizumab in Combination With Bevacizumab...

This phase III trial is comparing two immunotherapy drugs (Atezolizumab and Bevacizumab) with an oral targeted therapy (Sorafenib) in the treatment of previously untreated locally advanced or metastatic hepatocellular (liver) cancer

Cancer type : Liver

Multiple treatment types

RTOG 1112 : Randomized Phase III Study of Sorafenib Versus Stereotactic Body Radiation Therapy...

This phase III trial is trying to determine how well radiotherapy and an oral drug (sorafenib tosylate) work together in the treatment of patients with liver cancer

Cancer type : Liver

Systemic therapy trial

PHOCUS : A Phase 3 Randomized, Open-Label Study Comparing Pexa Vec (Vaccinia GM CSF / Thymidine...

This phase III trial is evaluating sorafenib, alone and in combination with immunotherapy treatment, in patients with hepatocellular (liver) cancer

Cancer type : Liver

Systemic therapy trial

CT711 : A Phase I/II Open-label, Dose Escalation Study to Investigate the Safety,...

This phase I/II trial is evaluating an oral drug (GSK525762) for the treatment of relapsed or refractory haematological conditions

Cancer type : Blood

Systemic therapy trial

LCH-IV : International Collaborative Treatment Protocol for Children and Adolescents With...

This phase II/III trial is looking at different treatment protocols for children and adolescents with Langerhans Cell Histiocytosis

Cancer type : Langerhans Cell Histiocytosis

Systemic therapy trial

CheckMate9ER : A Phase 3, Randomized, Open-Label Study of Nivolumab Combined With Cabozantinib Versus...

This phase III trial is comparing a doublet therapy (Nivolumab Combined With Cabozantinib) with a monotherapy (Sunitinib) in patients with advanced renal cell carcinoma that has spread to other parts of the body

Cancer type : Urinary System

Systemic therapy trial

KEYNOTE-564 : A Phase III, Randomized, Double-Blind, Placebo-Controlled Clinical Trial of Pembrolizumab...

This Phase III trial is evaluating an immunotherapy agent (Pembrolizumab) as a monotherapy for patients who have Renal Cell Carcinoma and have undergone a nephrectomy surgical procedure

Cancer type : Urinary System

Systemic therapy trial

CheckMate 914 : A Phase 3 Randomized Study Comparing Nivolumab and Ipilimumab Combination vs Placebo in...

This phase III trial is trying to determine whether the combination of two immunotherapy drugs (nivolumab and ipilimumab) is effective in preventing cancer recurrence in patients with renal cell carcinoma, who have had part or all of their kidney removed

Cancer type : Urinary System

Systemic therapy trial

CLEAR : A Multicenter, Open-label, Randomized, Phase 3 Trial to Compare the Efficacy and Safety...

This phase III trial is comparing three drugs (Lenvatinib in combination with Everolimus or Pembrolizumab) with another targeted drug (Sunitinib) as a first-line treatment for patients with advanced Renal Cell Carcinoma

Cancer type : Urinary System

Systemic therapy trial

Eisai 218 : A Randomized, Double-blind, Phase 2 Trial to Assess Safety and Efficacy of Lenvatinib at...

This phase II trial is evaluating two doses of Lenvatinib (an anti-cancer drug) in combination with Everolimus (an oral drug) in patients who have received prior treatment for Renal Cell Carcinoma

Cancer type : Urinary System

Radiotherapy trial

FASTRACK II : A Mulicentre Phase II clinical trial of STereotactic Ablative Body Radiotherapy for...

This phase II trial is trying to determine the effectiveness of using focal ablative stereotactic radiosurgery (targeted radiotherapy) for the treatment of primary kidney cancer

Cancer type : Kidney

Systemic therapy trial

HD21 : Treatment optimisation trial in the first-line treatment of advanced stage Hodgkin...

This phase III trial is comparing two 6-cycle chemotherapy treatments (BEACOPP and BrECADD) in the first-line treatment of advanced Hodgkin's Lymphoma

Cancer type : Hodgkin's Disease (Hodgkin's Lymphoma)

Systemic therapy trial

PLIMATH : A Multi-centre Phase II Study to Determine the Response Kinetics, Safety and Efficacy of...

This Phase II trial is evaluating the drug pembrolizumab (commonly used in immunotherapy) as a treatment for patients with newly diagnosed Hodkgin Lymphoma

Cancer type : Hodgkin's Disease (Hodgkin's Lymphoma)

Systemic therapy trial

EURONET-PHL-C2 : Second International Inter-Group Study for Classical Hodgkin Lymphoma in Children and...

This phase III trial is evaluating chemotherapy intensification in Hodgkin Lymphoma patients who receive less radiotherapy

Cancer type : Hodgkin's Disease (Hodgkin's Lymphoma)

Systemic therapy trial

KEYNOTE-204 : A Phase III, Randomized, Open-label, Clinical Trial to Compare Pembrolizumab With...

This phase III trial is evaluating pembrolizumab (an immunotherapy drug) as a treatment for patients with Hodgkin Lymphoma

Cancer type : Hodgkin's Disease (Hodgkin's Lymphoma)

Multiple treatment types

KEYNOTE-412 : A Randomized Phase III Study of Pembrolizumab Given Concomitantly With Chemoradiation and...

This phase III trial is trying to determine the effect of adding an immunotherapy drug (Pembrolizumab) to chemoradiation (CRT) concomitantly and as maintenance therapy in patients with locally advanced Head and Neck Squamous Cell Carcinoma (HNSCC)

Cancer type : Head and Neck

Multiple treatment types

JAVELIN HEAD AND NECK 100 : A Randomized Double-blind Phase 3 Study Of Avelumab In Combination With Standard Of Care...

This phase III trial is evaluating the addition of an immunotherapy drug (Avelumab) to standard chemoradiation as a first line treatment for locally advanced cancers of the head and neck

Cancer type : Head and Neck

Systemic therapy trial

Imvoke10 : A Phase III, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study of...

This phase III trial is evaluating an immunotherapy drug (Atezolizumab) for the treatment of high-risk locally advanced head and neck cancer

Cancer type : Head and neck

Systemic therapy trial

OZM-063 : A Phase II, Open-Labeled, Multi-Center, Randomized Controlled Trial of Vinblastine +/-...

This phase II trial is trying to determine the benefit of adding Bevacizumab (an intravenous drug) to chemotherapy treatment with Vinblastine, in children and adolescents with low grade gliomas

Cancer type : Glioma

Systemic therapy trial

BIOMEDE : Biological Medicine for Diffuse Intrinsic Pontine Glioma (DIPG) Eradication

This phase II trial is testing three oral drugs (Erlotinib, Everolimus and Dasatinib) as a possible treatment for Diffuse Intrinsic Pontine Glioma (DIPG)

Cancer type : Glioma

Systemic therapy trial

INTELLANCE 2 : ABT-414 Alone or ABT-414 Plus Temozolomide vs. Lomustine or Temozolomide for Recurrent...

This phase II trial is evaluating ABT414 alone and in combination with chemotherapy for patients with recurrent glioblastoma

Cancer type : Glioma

NAT-105 : A Feasibility Study of the Nativis Voyagerâ„¢ System in Patients With Recurrent...

This study will assess the effects of Nativis Voyager therapy in patients with recurrent Glioblastoma (GBM).

Cancer type : Brain and Spinal

Systemic therapy trial

P3BEP : Phase 3 Accelerated BEP Trial: A randomised phase 3 trial of accelerated versus standard...

This phase III trial is tyring to determine whether an accerated two-week treatment of BEP chemotherapy is as effective as receiving the standrard three-week cycle, for patients with metastatic germ cell tumours

Cancer type : Germ cell tumour

Systemic therapy trial

A Phase 3, INterVentional, Double-Blind, Placebo-Controlled Study to Assess the Safety...

This phase III trial is evaluating a new oral drug (DCC-2618) for the treatment of advanced gastrointestinal stromal tumours that have previously been treated

Cancer type : Stomach

Systemic therapy trial

PERSPECTIVE : A Multicenter, Randomized, Double-blind, Placebo-controlled Phase 3 Study of the Bruton's...

This phase III trial is trying to determine the benefit of adding an immunotherapy drug (Ibrutinib) to Rituximab treatment in patients who have been diagnosed with Follicular Lymphoma and not yet received treatment

Cancer type : Blood

Systemic therapy trial

CHRONOS-3 : A Phase III, Randomized, Double-blind, Placebo-controlled Study Evaluating the Efficacy...

This phase III trial is evaluating the drug rituximab, alone and in combination with copanlisib (another drug), for the treatment of Non Hodgkin Lymphoma

Cancer type : Blood

Systemic therapy trial

BGB3111_212 (FL) : An International, Phase 2, Open-Label, Randomized Study of BGB-3111 Combined With...

This phase II trial is evaluating Obinutuzumab alone and in combination with a new oral drug (BGB-3111) for the treatment of non-Hodgkin follicular lymphoma that has gotten worse or not responded to prior treatment

Cancer type : Follicular Lymphoma

Systemic therapy trial

1st FLOR : First-line Treatment for Grade 1-3A Follicular Lymphoma Using Opdivo (Nivolumab) Plus...

This phase I trial is trying to determine whether it is safe to give the drug Nivolumab before and in combination with the drug Rituximab, in patients who have previously untreated Follicular Lymphoma

Cancer type : Follicular Lymphoma

Systemic therapy trial

RePLY : ALLG NHL26 A Phase 2 Study of patients treated for relapsed Follicular Lymphoma: with...

This phase II trial is evaluating the combination of revlimid (chemotherapy) and rituximab maintenance therapy in the treatment of patients with Follicular Lymphoma

Cancer type : Follicular Lymphoma

Systemic therapy trial

iPRIME : A Phase II Study of Durvalumab and Tremelimumab in combination with Neoadjuvant...

This phase II trial is trying to determine how effective it is to combine two targeted cancer drugs (durvalumab and tremelimumab) with standard chemotherapy treatment in patients with ovarian, fallopian tube or peritoneal cancers

Cancer type : Female Reproductive System

Systemic therapy trial

A Phase 2 Study of Prexasertib in Platinum-Resistant or Refractory Recurrent Ovarian...

This phase II trial is evaluating an intravenous drug (prexasertib) in women with platinum-resistant or refractory recurrent ovarian cancer

Cancer type : Female Reproductive System

Systemic therapy trial

TREATT : A double blind, randomised controlled TRial EvaluAting the safety and efficacy of...

This phase III trial is trying to determine whether it is effective to give tranexamic acid (a drug that reduces heavy bleeding) to patients with Thrombocytopenia

Cancer type : Blood

Multiple treatment types

ACNS0831 : Phase III Randomized Trial of Post-Radiation Chemotherapy in Patients With Newly...

This phase III trial is comparing post-radiation chemotherapy and observation for the treatment of young people with newly diagnosed ependymomas

Cancer type : Ependymomas

Systemic therapy trial

VIP : Phase II Study of Intravenous Vinorelbine in Patients With Relapsed Platinum Resistant or...

This phase II trial is evaluating an intravenous drug (Vinorelbine) for the treatment of recurrent C5 high grade serous, endometrioid, or undifferentiated primary peritoneum, fallopian tube or ovarian cancer

Cancer type : Female Reproductive System

Systemic therapy trial

A Phase IB Combination Study of Rucaparib (CO-338) and Atezolizumab (MPDL3280A) in...

This phase I trial is combining two anti-cancer drugs (Rucaparib and Atezolizumab) in patients with advanced cancers of the female reproductive system, ovarian cancer in particular

Cancer type : Female Reproductive System

Systemic therapy trial

feMMe : A Phase II Randomised Clinical Trial of Mirena ± Metformin ± Weight Loss Intervention in...

This phase II trial is trying to determine whether the use of mirena, metformin or a weight loss intervention is effective in the treatment of early-stage endometrial cancer

Cancer type : Endometrium

Systemic therapy trial

CARINA : An Open Label, Phase 2 Study to Evaluate Efficacy and Safety of Daratumumab in Relapsed...

This phase II trial is evaluating an anti-cancer drug (daratumumab) for the treatment of Follicular, Mantle Cell and Diffuse Large Cell Lymphoma

Cancer type : Blood

Systemic therapy trial

Harmony : A Phase Ib/II Study Evaluating the Safety and Efficacy of Obinutuzumab in Combination...

This phase I/II trial is combining two investigational agents (obinutuzumab and rituximab) with two drugs (polatuzumab vedotin and venetoclax) in the treatment of Follicular Lymphoma and Diffuse Large Cell Lymphoma

Cancer type : Blood

Systemic therapy trial

B-MIND : A Phase 2/3, Randomised, Multicentre Study of MOR208 With Bendamustine Versus Rituximab...

This phase II/III trial is combining bendamustine (a chemotherapy drug) with either MOR208 or rituximab (two types of antibody therapy) for the treatment of Diffuse Large B-cell Lymphoma

Cancer type : Diffuse Large Cell Lymphoma

Systemic therapy trial

Regeneron 2 : A Phase 2 Study of REGN2810, a Fully Human Monoclonal Antibody to Programmed Death-1...

This phase II trial is evaluating the drug REGN2810 as a monotherapy for people with metastatic or locally advanced cutaneous squamous cell carcinoma (CSCC)

Cancer type : Cutaneous Squamous Cell Carcinoma (CSCC)

Systemic therapy trial

BGB-3111-304 (TN CLL) : An International, Phase 3, Open-Label, Randomized Study of BGB-3111 Compared With...

This phase III trial is comparing an oral drug (BGB-3111) with a combined treatment of Bendamustine and Rituximab, in patients with previously untreated Chronic Lymphocytic Leukaemia (CLL) or Small Lymphocytic Lymphoma (SLL)

Cancer type : Blood

Systemic therapy trial

Captivate : Phase 2 Study of the Combination of Ibrutinib Plus Venetoclax in Subjects With...

This phase II trial is combining a targetted therapy (ibrutinib) with a chemotherapy drug (venetoclax) for the treatment of Chronic Lymphocytic Leukaemia and Small Lymphocytic Leukaemia

Cancer type : Blood

Systemic therapy trial

KEYNOTE-155 : Phase Ib Trial of Pembrolizumab (MK-3475) in Combination With Dinaciclib (MK-7965) in...

This phase I trial is combining pembrolizumab (an immunotherapy drug) and dinaciclib (an investigational agent) for the treatment of Multiple Myeloma, Diffuse Large Cell Lymphoma and Chronic Lymphocytic Leukaemia

Cancer type : Blood

Systemic therapy trial

M14-728 : A Phase 2 Open-Label Study of the Efficacy of Venetoclax in Subjects With Relapsed or...

This phase II trial is evaluating an oral chemotherapy drug (Venetoclax) in participants with Chronic Lymphocytic Leukaemia (CLL)

Cancer type : Chronic Lymphocytic Leukaemia

Systemic therapy trial

OFOCIR : An Australasian, phase II, multicentre, randomised, dose intensification study...

This phase II trial is assessing two oral drugs and one intravenous drug in previously untreated elderly patients with Chronic Lymphocytic Leukaemia (CLL)

Cancer type : Chronic Lymphocytic Leukaemia

Systemic therapy trial

ACE-CL-006 : A Randomized, Multicenter, Open-Label, Non-Inferiority, Phase 3 Study of ACP-196 Versus...

This phase III trial is evaluating two drugs (acalabrutinib and ibrutinib) for the treatment of patients who have been diagnosed Chronic Lymphocytic Leukemia (CLL)

Cancer type : Chronic Lymphocytic Leukaemia

Systemic therapy trial

ACE-CL-309 : A Randomized, Multicenter, Open-Label, Phase 3 Study of Acalabrutinib (ACP-196) Versus...

This phase III trial is evaluating acalabrutinib and rituximab (two anti-cancer drugs), given in combination with idelalisib or bendamustine (chemotherapy), for the treatment of Chronic Lymphocytic Leukaemia (CLL)

Cancer type : Chronic Lymphocytic Leukaemia

Systemic therapy trial

CheckMate 908 : Phase Ib /II Clinical Trial of Nivolumab Monotherapy and Nivolumab in Combination With...

This phase I/II trial is evaluating two biological therapies (Nivolumab alone and in combination with Ipilimumab) in children and adolescents that have been diagnosed with advanced Central Nervous System (CNS) cancers

Cancer type : Brain and Spinal

Systemic therapy trial

A Phase II, Multicenter, Randomized Study To Compare The Efficacy Of Venetoclax Plus...

This phase II trial is trying to determine whether it is more effective to give a type of hormonal treatment (Fulvestrant) alone or in combination with an oral chemotherapy drug (Venetoclax) in the treatment of ER+, HER2 negative locally advanced or metastatic breast cancer that has come back or gotten worse after treatment

Cancer type : Breast

Systemic therapy trial

Morpheus-TNBC : A Phase Ib/II, Open-Label, Multicenter, Randomized Umbrella Study Evaluating The Efficacy...

This phase I/II trial is evaluating various immunotherapy based treatment combinations as a way of treating patients with a Triple Negative Breast Cancer (TNBC) that has spread to other parts of the body

Cancer type : Breast

Systemic therapy trial

IPATunity130 : A Double-Blind, Placebo-Controlled, Randomized Phase III Study of Ipatasertib in...

This phase II/III trial is evaluating an oral drug (Ipatasertib) alone and in combination with a chemotherapy drug, for the treatment of advanced triple negative breast cancer or hormone receptor-positive, HER-2 negative breast cancer

Cancer type : Breast

Systemic therapy trial

monarchE : A Randomized, Open-Label, Phase 3 Study of Abemaciclib Combined With Standard Adjuvant...

This phase III trial is evaluating the addition of an oral drug (Abemaciclib) to standard adjuvant endocrine therapy in patients with high risk, early stage, hormone receptor and node positive, HER 2- breast cancer

Cancer type : Breast

Multiple treatment types

Local HER-O : A Phase II study of local therapy only (stereotactic radiosurgery and/or surgery) for...

This phase II trial is using radiosurgery and/or surgery to treat brain metastases that have spread from HER 2+ breast cancer

Cancer type : Breast

Systemic therapy trial

A Phase I/II Dose Escalation and Expansion Study to Investigate the Safety,...

This phase II trial is evaluating two drugs (oral GSK525762 tablets and a Fulvestrant injection) in patients with a breast cancer that has spread to other parts of the body and progressed after a previous treatment

Cancer type : Breast

Radiotherapy trial

EXPERT : A Randomised Phase III Trial of Adjuvant Radiation Therapy Versus Observation Following...

This phase III trial is examining personalised radiation therapy for low-risk early breast cancer

Cancer type : Breast

Systemic therapy trial

HER2CLIMB : Phase 2 Randomized, Double-Blinded, Controlled Study of Tucatinib vs Placebo in...

This phase II trial is evaluating the addition of an oral drug (Tucatinib) to treatment with Capecitabine and Trastuzumab in patients with an advanced HER 2+ Breast Cancer that has spread to other parts of the body

Cancer type : Breast

Systemic therapy trial

OlympiA : A Randomised, Double-blind, Parallel Group, Placebo-controlled Multi-centre Phase III...

This phase III trial is evaluating an oral drug (Olaparib) as an adjuvant therapy in patients with primary (gBRCA 1/2, HER2-) breast cancer

Cancer type : Breast

Systemic therapy trial

METRIC : A Randomized Multicenter Pivotal Study of CDX-011 (CR011-vcMMAE)in Patients With...

This phase II trial will determine whether CDX-011 is an effective treatment for people with triple negative breast cancer

Cancer type : Breast

Systemic therapy trial

SETUP : Neoadjuvant chemotherapy with docetaxel and anthracycline based chemotherapy in patients...

This phase III trial is assessing the safety and effectiveness of neoadjuvant chemotherapy, with docetaxel and anthracycline, in patients with advanced breast cancer

Cancer type : Breast

Systemic therapy trial

BL12 : A Multicentre Randomized Phase II Trial Comparing Nab-Paclitaxel to Paclitaxel in...

This phase II trial is comparing two types of chemotherapy (Nab-Paclitaxel and Paclitaxel) in patients with advanced urothelial cancer

Cancer type : Urinary System

Systemic therapy trial

CA209-901 : A Phase 3, Open-label, Randomized Study of Nivolumab Combined With Ipilimumab, or With...

This phase III trial is trying to determine whether the combination of two investigational immunotherapies (ipilimumab and nivolumab) or the combination of an investigational immunotherapy (nivolumab) and chemotherapy is better than recieveing chemotherapy alone in treating patients with urothelial cancer that has spread to other parts of their body

Cancer type : Urinary System

Systemic therapy trial

PCR-MIB study : Pembrolizumab With Chemoradiotherapy as Treatment for Muscle Invasive Bladder Cancer

This phase II study is assessing the safety and feasibility of combining pembrolizumab (an immunotherapy agent) with chemoradiotherapy in the treatment of bladder cancer

Cancer type : Bladder

Systemic therapy trial

BCG+MMC : Adding mitomycin C to Bacillus of Calmette-Guerin (BCG) as adjuvant intravesical therapy...

This phase III trial is looking at the effect of adding mitomycin C (a chemotherapy drug) to standard treatment, in patients with invasive bladder cancer

Cancer type : Bladder

Systemic therapy trial

TreeTopp : A Multicenter, Double-Blind, Randomized, Placebo-Controlled Study of Varlitinib Plus...

This phase II/III trial is evaluating two oral drugs (Varlitinib and Capecitabine) in the treatment of Biliary Tract Cancer

Cancer type : Bile duct

Systemic therapy trial

CITADEL-203 : A Phase 2, Multicenter, Open-Label Study of INCB050465, a PI3Kδ Inhibitor in Relapsed or...

This phase II trial is evaluating whether a new drug (INCB050465) will be an effective treatment option for patients with follicular lymphoma who have gotten worse or not responded on other therapies

Cancer type : Blood

Systemic therapy trial

CHRONOS-4 : A Phase III, Randomized, Double-blind, Controlled Multicenter Study of Intravenous PI3K...

This phase III trial is adding the investigational drug copanlisib, to standard immunochemotherapy (R-B or R-CHOP) for patients with Non Hodgkin Lymphoma

Cancer type : Blood

Systemic therapy trial

JASMINE : A Randomized, Double-Blind Study Evaluating the Efficacy, Safety and Immunogenicity of...

This phase III trial is comparing an investigational drug (ABP 798) with rituximab (another drug) for the treatment of B-Cell Non Hodgkin Lymphoma

Cancer type : Blood

Systemic therapy trial

A Phase 1B Study Evaluating RO7082859 in Combination With Rituximab (R) or Obinutuzumab...

This phase I trial is combining a new intravenous drug (RO7082859) with an immunotherapy (Rituximab or Obinutuzumab) and chemotherapy (CHOP) treatment in patients with newly diagnosed Diffuse Large B-Cell Lymphoma (DLBCL)

Cancer type : Blood

Systemic therapy trial

CAPILANO : A Phase 2 Open-Label Study to Determine the Effect of Blinatumomab on Minimal Residual...

This phase II trial is evaluating the effectiveness of an intravenous drug (Blinatumomab) in treating patients with High-risk Diffuse Large B-cell Lymphoma following an autologous Hematopoietic Stem-cell Transplantation

Cancer type : Blood

Systemic therapy trial

AvR-CHOP : Feasibility Study of Induction and Maintenance Avelumab Plus R-CHOP in Patients With...

This phase I trial is assessing induction and maintenance therapy (with Avelumab and R-CHOP chemotherapy) in patients with Diffuse Large B Cell Lymphoma (DLBCL)

Cancer type : Blood

Systemic therapy trial

BGB-3111-BGB-A317 : A Phase 1b, Open Label, Multiple Dose, Dose Escalation and Expansion Study to Assess...

This phase I trial is evaluating the oral drug BGB-3111 in combination with BGB-A317 for patients with B-Cell Lymphoma

Cancer type : Blood

Systemic therapy trial

HMPL-523 : A Phase I, open-label, dose-escalation study of the safety and pharmacokinetics of...

This phase I trial is evaluating a drug (HMPL-523) in patients with Chronic Lymphocytic Leukaemia, Lymphoma and Multiple Myeloma

Cancer type : Blood

Systemic therapy trial

BGB-3111_001 : A Phase 1b Study to Assess Safety, Tolerability and Antitumor Activity of the Combination...

This phase I trial is evaluating an oral drug (BGB-3111) in combination with another drug (obinutuzumab) for the treatment of B-Cell Non Hodgkin Lymphoma

Cancer type : Blood

Systemic therapy trial

GO29365 : A Phase IB/II Study Evaluating The Safety, Tolerability and Anti-Tumor Activity of...

This phase I/II trial is testing a new investigational drug called Polatuzumab vedotin in combination with a standard dose of Bendamustine (a chemotherapy drug), Rituximab (a biological therapy) or Obinutuzumab (another chemotherapy drug) in patients with follicular lymphoma (FL) or diffuse large B-cell lymphoma (DLBCL)

Cancer type : Blood

Systemic therapy trial

CITADEL-202 : A Phase 2, Multicenter, International, Open-Label, Safety and Efficacy Study of...

This phase II trial is testing an investigational drug (INCB050465) in patients with Diffuse Large B-Cell Lymphoma that has gotten worse or is not responsive to treatment

Cancer type : Blood

Systemic therapy trial

BGB-3111 : A Phase IA, Open Label, Multiple Dose, Dose Escalation Study to Investigate the Safety...

This phase I trial is investigating a new drug (BGB3111) for the treatment of B-Cell Lymphomas

Cancer type : Blood

Systemic therapy trial

RATIONAL : A randomised controlled feasibility trial comparing the efficacy of prophylactic...

This phase II trial is comparing an oral antbiotic treatment with an intravenous treatment for patients with blood cancer who have low levels of antibodies in their blood (hypogammaglobulinemia)

Cancer type : Blood

Systemic therapy trial

BGB-3111-302 : A Phase 3, Randomized, Open-Label, Multicenter Study Comparing the Efficacy and Safety of...

This phase III trial is comparing two drugs (BGB-3111 and ibrutinib) in the treatment of Waldenström's Macroglobulinemia (a type of Non Hodgkin Lymphoma)

Cancer type : B-Cell Non Hodgkin Lymphoma

Systemic therapy trial

BLIN : A Phase 2/3 Multi-center Study to Evaluate the Safety and Efficacy of Blinatumomab in...

This phase II/III trial is evaluating a drug (Blinatumomab) for the treatment of relapsed or refractory B-Cell Non-Hodgkin Lymphoma

Cancer type : B-Cell Non Hodgkin Lymphoma

Systemic therapy trial

A Phase 3 Randomized Double-Blind Placebo-Controlled Study Investigating the Efficacy and...

This phase III trial is evaluating a treatment for anaemia in patients with lower risk Myelodysplastic Syndrome (MDS) and low red blood cell (RBC) transfusion burden (LTB)

Cancer type : Blood

Systemic therapy trial

AAML1331 : A Phase III Study for Patients With Newly Diagnosed Acute Promyelocytic Leukemia (APL)...

This phase III trial is evaluating tretinoin and arsenic trioxide for the treatment of patients with newly diagnosed Acute Promyelocytic Leukemia

Cancer type : Acute Promyelocytic Leukaemia

Systemic therapy trial

A Phase 1/2, Multicenter, Open-label Study of FT-2102 as a Single Agent and in...

This phase I/II trial is evaluating an oral drug (FT-2102) alone and in combination with a chemotherapy drug (Cytarabine or Azacitidine) in patients with Acute Myeloid Leukaemia (AML) or Myelodysplastic Syndrome

Cancer type : Blood

Systemic therapy trial

GOSSAMER ASTELLAS : A Phase 3 Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial of the FLT3...

This phase III trial is assessing the relapse-free survival of patients who are in complete first remission for Acute Myeliod Leukaemia (AML) and who are randomised to receive gilteritinib after they have completed two years of induction chemotherapy

Cancer type : Blood

Systemic therapy trial

S055746 : Phase I dose-escalation study of the orally administrered selective Bcl-2 inhibitor...

This phase I trial is assessing the oral administration of the drug S 055746 in patients with Acute Myeloid Leukaemia or Myelodysplastic Syndrome

Cancer type : Blood

Systemic therapy trial

MAX-40279-001 : A Phase I Trial of MAX-40279 Given Orally to Subjects With Acute Myelogenous Leukemia...

This phase I trial is testing a new oral drug (MAX-40279) for the treatment of Acute Myelogenous Leukaemia (AML)

Cancer type : Acute Myeloid Leukaemia

Systemic therapy trial

ASLAN003-003 : A Phase IIA Dose Optimisation Study of ASLAN003 in Acute Myeloid Leukemia

This Phase II trial is evaluating a new oral drug (ASLAN003) as a single treatment for Acute Myeloid Leukaemia (AML)

Cancer type : Acute Myeloid Leukaemia

Systemic therapy trial

A Phase 1 First-In-Human Study Evaluating the Safety, Tolerability, Pharmacokinetics,...

This early Phase I trial is evaluating a new drug (AMG 673), administered intravenously to patients with Acute Myeloid Leukaemia (AML) that has gotten worse or come back following prior therapy

Cancer type : Acute Myeloid Leukaemia

Systemic therapy trial

M15-656 - AML (Venetoclax/Aza) : A Randomized, Double-Blind, Placebo Controlled Phase 3 Study of Venetoclax in Combination...

This phase III trial is trying to determine whether adding venetoclax (an oral drug) to azacitidine treatment works better than azacitidine treatment on its own in patients with newly diagnosed Acute Myeloid Leukaemia (AML)

Cancer type : Acute Myeloid Leukaemia

Systemic therapy trial

MORPHO : A Multi-center, Randomized, Double-blind, Placebo-controlled Phase III Trial of the FLT3...

This phase III trial is comparing the outcomes of patients with acute myeloid leukaemia (AML) who receive an oral drug (gilteritinib) following stem cell transplantation, with those who receive stem cell transplantation alone

Cancer type : Acute Myeloid Leukaemia

Systemic therapy trial

PRIMULA : A Phase III, Double-Blind, Placebo-Controlled, Multicenter, Randomized Study Of...

This phase III trial is combining two drugs (Pracinostat and Azacitidine) in patients with newly diagnosed Acute Myeloid Leukaemia (AML)

Cancer type : Acute Myeloid Leukaemia

Systemic therapy trial

M14-387 : A Phase 1/2 Study of ABT-199 in Combination With Low-Dose Cytarabine in Treatment-Naive...

This phase I/II trial is combining two chemotherapy drugs (venetoclax and cytarabine) in people who haven't received treatment for Acute Myelogenous Leukemia (AML)

Cancer type : Acute Myeloid Leukaemia

Systemic therapy trial

CAVEAT : A phase Ib clinical evaluation of Venetoclax in combination with chemotherapy in older...

This phase I trial is evaluating the investigational drug, venetoclax, in combination with chemotherapy for the treatment of Acute Myeloid Leukaemia (AML)

Cancer type : Acute Myeloid Leukaemia

Systemic therapy trial

S64315 : Phase I, International, Multicentre, Open-label, Non-randomised, Non-comparative Study of...

This phase I trial is evaluating an intravenously administered drug (S64315) for the treatment of Acute Myeloid Leukaemia (AML) or Myelodysplastic Syndrome

Cancer type : Acute Myeloid Leukaemia

Systemic therapy trial

Phase I Open Label, Multi-center Study to Characterize the Safety, Tolerability and...

This phase I trial is assessing a new drug (MIK665) that will be given intravenously in patients with advanced Lymphoma or Multiple Myeloma

Cancer type : Blood

Systemic therapy trial

Interfant 06 : International collaborative treatment protocol for infants under one year with acute...

This trial is studying how well different therapies work in treating infants with newly diagnosed acute leukemia

Cancer type : Acute Lymphoblastic Lymphoma

Systemic therapy trial

AALL0932 : Treatment of Patients With Newly Diagnosed Standard Risk B-Precursor Acute Lymphoblastic...

This phase III trial is evaluating different combinations of chemotherapy for the treatment of children who have Lymphoblastic Leukaemia or Lymphoblastic Lymphoma

Cancer type : Blood

Systemic therapy trial

M16-106 : A Phase 1 Dose Escalation, Open-Label Study of Venetoclax in Combination With Navitoclax...

This phase I trial is combining two oral drugs (Venetoclax and Navitoclax) with chemotherapy in patients with Acute Lymphoblastic Leukaemia (ALL) or Lymphoblastic Lymphoma that has gotten worse or not responded to treatment

Cancer type : Blood

Systemic therapy trial

BLAM : A phase IIb study of Blinatumomab + Cytarabine (AraC) and Methotrexate in adult...

This phase II trial is evaluating a biological and chemotherapy treatment protocol (Blinatumomab + Cytarabine (AraC) and Methotrexate) for patients with Acute Lymphoblastic Leukaemia

Cancer type : Acute Lymphoblastic Leukaemia

Systemic therapy trial

IntReALL SR 2010 : International Study for Treatment of Standard Risk Childhood Relapsed ALL 2010 A...

This phase III trial is evaluating treatment options for children and adolescents with standard risk of first relapsed Acute Lymphoblastic Leukemia (ALL)

Cancer type : Acute Lymphoblastic Leukaemia

Systemic therapy trial

AALL1131 : A Phase III Randomized Trial for Newly Diagnosed High Risk B-precursor Acute...

This phase III trial is trying to determine how well combination chemotherapy works in treating young patients with newly diagnosed B-Cell Acute Lymphoblastic Leukaemia that is likely to come back or spread

Cancer type : Acute Lymphoblastic Leukaemia

Systemic therapy trial

REACH2 : A Phase III Randomized Open-label Multi-center Study of Ruxolitinib Versus Best Available...

This phase III trial is comparing an oral drug (Ruxolitinib) with the best available therapy in patients with Acute Graft vs. Host Disease

Cancer type : Graft versus Host disease

Systemic therapy trial

PRE-TREAT : A window study to determine short-term effects of Pre-operative Treatment with tamoxifen...

This study is trying to determine the effects of having short term endocrine therapy (tamoxifen or letrozole) in the treatment of newly diagnosed oestrogen receptor positive breast cancer

Cancer type : Breast

Surgical trial

SNAC2 : A randomised phase III study to determine in women with early breast cancer whether...

This phase III trial is assessing the effect of sentinal node based management on risk of recurrence in patients with early stage breast cancer

Cancer type : Breast

Systemic therapy trial

ROBIN : A Randomised, Open Label, Multi-centre, Phase III Study to Investigate the Efficacy of...

This phase III trial is comparing bendamustine (a chemotherapy drug) with another treatment (chosen by the investigator) in patients with Non-Hodgkin Lymphoma

Cancer type : B-Cell Non Hodgkin Lymphoma

Systemic therapy trial

MIRROS : A Multicenter, Double-Blind, Randomized, Placebo-Controlled, Phase III Study of...

This phase III trial evaluating a drug (cytarabine) alone and in combination with a chemotherapy (idasanutlin) for the treatment of Acute Myeloid Leukaemia (AML)

Cancer type : Acute Myeloid Leukaemia

Systemic therapy trial

PonAZA : A phase Ib/II clinical evaluation of Ponatinib in combination with 5-azacytidine in...

This phase I/II trial is combining an oral drug (ponatinib) with 5- azacitidine for the treatment of Acute Myeloid Leukaemia (AML)

Cancer type : Acute Myeloid Leukaemia

Systemic therapy trial

CX-5461 : A Phase 1, Open-Label, Dose Escalation, Safety, Pharmacokinetic, and Pharmacodynamic...

This phase I trial is evaluating an intravenously administered drug (CX-5461) for the treatment of advanced blood cancer

Cancer type : Blood

Systemic therapy trial

AML-001 : A Phase 3, Randomized, Double-blind, Placebo-controlled Study to Compare Efficacy and...

This phase III trial is comparing best supportive care with and without oral azacitidine (chemotherapy) as a maintenance therapy for patients in remission for Acute Myeloid Leukaemia (AML)

Cancer type : Acute Myeloid Leukaemia

Systemic therapy trial

CT803 : A Phase 1 First in Human Study Evaluating the Safety, Tolerability, Pharmacokinetics and...

This phase I trial is evaluating an investigational drug (AMG 176) in patients with Multiple Myeloma

Cancer type : Multiple Myeloma

Systemic therapy trial

IDHENTIFY : A Phase 3, Multicenter, Open-label, Randomized Study Comparing the Efficacy and Safety of...

This phase III trial is comparing an investigational drug (AG-221) with standard treatment in older patients with Acute Myeloid Leukaemia (AML)

Cancer type : Acute Myeloid Leukaemia

Systemic therapy trial

ALLG AML M16 : Sorafenib in combination with intensive chemotherapy for previously untreated adult...

This phase II trial is investigating the role of the drug sorafenib, given in combination with intensive chemotherapy for the treatment of Acute Myeloid Leukaemia (AML)

Cancer type : Acute Myeloid Leukaemia

Systemic therapy trial

CT787 : A Non-Randomised Open-Label Phase Ib Exploratory Study of TG02-treatment as Monotherapy...

This phase Ib trial is testing an investigational TG02 treatment in patients with locally recurrent rectal cancer

Cancer type : Rectum

Systemic therapy trial

PIKNIC : A Phase II Exploratory, Open-label, Single Arm Study of BYL719 Monotherapy, a Selective...

This phase II trial is investigating the oral drug BYL719 as a monotherapy for people with advanced metastatic breast cancer after first line treatment

Cancer type : Breast

Systemic therapy trial

M14-031 : A Phase 3, Multicenter, Randomized, Double Blind Study of Bortezomib and Dexamethasone in...

This phase III trial is evaluating two drugs (bortezomib and dexamethasone) in combination with a chemotherapy drug (venetoclax) for the treatment of Multiple Myeloma

Cancer type : Multiple Myeloma

Systemic therapy trial

HCT versus CT : Randomized Phase III Study Comparing Conventional Chemotherapy to Low Dose Total Body...

This phase III trial is comparing two types of consolidation therapy (standard chemotherapy and hematopoietic cell transplantation) for patients in complete remission for Acute Myeloid Leukaemia (AML)

Cancer type : Acute Myeloid Leukaemia

Systemic therapy trial

ALLG MM16 : Phase II study assessing the effect of carfilzomib treatment on early free light chain...

This phase II trial is assessing carfilzomib (an anti-cancer drug) in patients with Multiple Myeloma who suffer from renal damage

Cancer type : Multiple Myeloma

Systemic therapy trial

PANORAMA_3 : A Multicenter, Randomized, Open-label Phase 2 Study Evaluating the Safety and Efficacy of...

This phase II trial is evaluating three ways to administer an oral drug (panobinostat) in combination with chemotherapy (subcutaneous bortezomib) and steroids (dexamethasone) for the treatment of Multiple Myeloma

Cancer type : Multiple Myeloma

Systemic therapy trial

CR107273 : A Randomized Phase 2/3 Study of DACOGEN® (Decitabine) Plus JNJ-56022473 (Anti CD123)...

This phase II/III trial is evaluating the investigational drug, talacotuzumab, alone and in combination with decitabine (an anti-cancer chemotherapy) for the treatment of Acute Myeloid Leukaemia (AML)

Cancer type : Acute Myeloid Leukaemia

Systemic therapy trial

C16021 : A Phase 3, Randomized, Placebo-Controlled, Double-Blind Study of Oral Ixazomib...

This phase III trial is testing an oral chemotherapy drug (ixazomib) as a maintenance therapy for patients with newly diagnosed Multiple Myeloma

Cancer type : Multiple Myeloma

Systemic therapy trial

M17 : A Strategy of High-Dose Lenalidomide in Combination with Epigenetic Therapies for...

This phase I trial is evaluating a chemotherapy drug (lenalidomide) with epigenetic therapy for the treatment of Acute Myeloid Leukaemia (AML)

Cancer type : Blood

Systemic therapy trial

ITD : A prospective, multi-centre, single arm, phase 2 assessment of the efficacy and safety of...

This phase II trial is combining three drugs (ixazomib, thalidomide and a steroid) for the treatment of relapsed and/or refractory multiple myeloma

Cancer type : Multiple Myeloma

Systemic therapy trial

PIM447 : A Phase Ib, Multi-center, Open-label, Dose-escalation Study of PIM447 in Combination With...

This phase I trial is evaluating the investigational agent, PIM447, in combination with ruxolitinib (a targetted therapy) and LEE011 (an oral drug) for the treatment of Myelofibrosis

Cancer type : Myelofibrosis

Systemic therapy trial

CFZ008 : Phase 1b/2 Study of Carfilzomib in Combination With Dexamethasone, Mitoxantrone,...

This phase I/II trial is trying to determine how much carfilzomib (an anti-cancer drug) should be used, alone and in combination with induction chemotherapy, to treat children with Acute Lymphoblastic Leukaemia (ALL)

Cancer type : Acute Lymphoblastic Leukaemia

FORUM : Allogeneic Stem Cell Transplantation for Children and Adolescents With Acute...

This phase II/III trial is evaluating allogenic stem cell transplatation as an optimal therapy for children and adolescents diagnosed with Acute Lymphoblastic Leukaemia (ALL)

Cancer type : Acute Lymphoblastic Leukaemia

Systemic therapy trial

Oral LGH447 : A Phase I, Multicenter, Open-label Study of Oral LGH447 in Patients With Acute Myeloid...

This phase I trial is evaluating an oral drug (LGH447) alone and in combination with midostaurin for the treatment of Acute Myeloid Leukaemia or Myelodysplastic Syndrome

Cancer type : Blood

Systemic therapy trial

GSK200200 - LSD1 : A Phase I Open-label, Dose Escalation Study to Investigate the Safety, Pharmacokinetics,...

This phase I trial is assessing an oral drug (GSK2879552) in patients with relapsed Acute Myeloid Leukaemia (AML)

Cancer type : Acute Myeloid Leukaemia

Systemic therapy trial

NCT02393859 : Phase 3 Trial to Investigate the Efficacy, Safety, and Tolerability of Blinatumomab as...

This phase III trial is trying to determine whether blinatumomab (a drug) is better as a consolidation therapy than standard chemotherapy for patients with Acute Lymphoblastic Leukaemia (ALL)

Cancer type : Acute Lymphoblastic Leukaemia

Systemic therapy trial

RV-003607 : Lenalidomide consolidation post allogeneic stem cell transplant for patients with high...

This phase II trial is evaluating lenalidomide as a maintenance therapy for patients with high risk multiple myeloma who have receivied an allogenic stem cell transplant

Cancer type : Multiple Myeloma

Surgical trial

Sentinal : Prospective collection of clinical data following sentinel node biopsy for vulval...

This trial will collect data following a sentinal node biopsy in patients with vulval carcinoma

Cancer type : Vulva

Radiotherapy trial

SHRINC : A Phase II Prospective Trial of Stereotactic Hypofractionated Radiation for Multiple...

This phase II trial is assessing a type of radiotherapy treatment for patients whose cancer has spread to the brain

Cancer type : Multi-Cancer

Systemic therapy trial

A Phase I, Open-Label, Dose-Escalation Study of the Safety and Pharmacokinetics of...

This phase I trial is evaluating a new intravenous drug (BTRC4017A) in patients with locally advanced or metastatic HER2-expressing cancers

Cancer type : Multi-Cancer

Systemic therapy trial

A317/290 : A Phase 1b, Open Label, Multiple Dose, Dose Escalation and Expansion Study to Investigate...

This phase I trial is combining BGB-A317 and BGB-290 for the treatment of advanced cancers (excluding blood cancer)

Cancer type : Multi-Cancer

Systemic therapy trial

CT898 : A Phase 1 First Time in Human Study to Evaluate the Safety, Pharmacokinetics and...

This phase I trial is comparing a biological therapy (MEDI5083) alone and in combination with an immunotherapy agent (Durvalumab) for the treatment of select advanced cancers

Cancer type : Multi-Cancer

Systemic therapy trial

CT855 : A Phase I, Open-label, Multi-center, Dose Escalation Study to Assess the Safety,...

This phase I trial is trying to determine whether or not the drug HMPL-453 is effective in treating patients with advanced cancers (excluding blood cancer)

Cancer type : Multi-Cancer

Systemic therapy trial

STORM : A Phase 1, Dose-finding and Signal-seeking Study of the Safety and Efficacy of...

This phase I trial is evaluating an intravenously administered immunotherapy (CAVATAK) alone and in combination with pembrolizumab, for the treatment of non-small cell lung cancer, prostate cancer, melanoma and bladder cancer

Cancer type : Multi-Cancer

Radiotherapy trial

SC-24 : A Randomized Phase II/III Study Comparing Stereotactic Body Radiotherapy(SBRT) Versus...

This phase II/III trial is comparing conventional radiotherapy and stereotactic radiotherapy in patients with spinal metastases

Cancer type : Multi-Cancer

Systemic therapy trial

BGB-900-103 : A Phase 1b Study to Assess the Safety, Tolerability, Pharmacokinetics, and Preliminary...

This phase I trial is combining an oral drug (sitravatinib) with an immuno-oncology drug (Tislelizumab) for the treatment of patients with locally advanced or metastatic Non-small Cell Lung Cancer (NSCLC), Renal Cell Carcinoma (RCC) or Ovarian Cancer (OC)

Cancer type : Multi-Cancer

Systemic therapy trial

Rare cancers : A Phase II Clinical Trial Evaluating Ipilimumab and Nivolumab in Combination for the...

This phase II trial is evaluating two immunotherapy drugs (Ipilimumab and Nivolumab) for the treatment of rare gastrointestinal, neuroendocrine and female reproductive cancers

Cancer type : Multi-Cancer

Systemic therapy trial

Oraxol : A Randomized Crossover Study to Determine the Bioequivalence of Three Consecutive Daily...

This phase I trial is comparing oral versus intravenous (IV) chemotherapy in patients for whom IV chemotherapy (paclitaxel 80mg/m2) has been recommended by their oncologist

Cancer type : Multi-Cancer

Systemic therapy trial

AMG T-vec : A Phase 1b Study of Talimogene Laherparepvec in Combination With Atezolizumab in Subjects...

This phase 1b trial is combining two different biological injections (a talimogene laherparepvec injection into the liver and an atezolizumab injection into the vein) in patients who have triple negative breast cancer or colorectal cancer that has spread to the liver

Cancer type : Multi-Cancer

Systemic therapy trial

CT832 : A Phase 1/1b, Open-Label, Multicenter, Repeat-Dose, Dose-Selection Study of CPI-444 as...

This phase I trial is evaluating a new drug (CPI-444) alone and in combination with atezolizumab in patients with advanced cancers

Cancer type : Multi-Cancer

Systemic therapy trial

CT789 : A Phase 1/2a Study of BMS-986205 Administered in Combination With Nivolumab (Anti-PD-1...

This phase I/II immunotherapy trial is using a new drug (BMS-986205) in combination with Nivolumab and Ipilimumab for the treatment of cancers that are advanced or have spread

Cancer type : Multi-Cancer

Systemic therapy trial

C-Stone : A Phase Ia/Ib, Open-Label, Multiple-Dose, Dose-Escalation and Expansion Study of the...

This phase I trial is evaluating the safety and effectiveness of a new biological drug (CS1003) in patients with advanced cancers

Cancer type : Multi-Cancer

Systemic therapy trial

CT958 : Phase 1/2 Study Investigating Safety, Tolerability, Pharmacokinetics and Preliminary...

This phase I/II trial is evaluating two anti-PD-L1 monoclonal antibodies in patients who have advanced cancers (excluding some blood cancers)

Cancer type : Multi-Cancer

Systemic therapy trial

Javelin Chemotherapy Medley : A Multicenter, Open-label, Phase 1b/2 Study To Evaluate Safety And Efficacy Of Avelumab...

This phase I/II trial is evaluating the safety and effectiveness of an immunotherapy (Avelumab) when given in combination with a chemotherapy (gemcitabine / cisplatin) or another type of immunotherapy (pemetrexed / carboplatin) in the treatment of advanced cancer

Cancer type : Multi-Cancer

Systemic therapy trial

An open-label, multi-centre Phase Ib study of the safety and tolerability of IV infused...

This phase I trial is assessing the combination of a new intravenous drug (PG545) and an immunotherapy drug (Nivolumab) in patients with advanced solid cancers, as well as patients with metastatic pancreatic cancer

Cancer type : Multi-Cancer

Systemic therapy trial

A Study to Evaluate the Safety, Pharmacokinetics and Clinical Activity of RO6870810 and...

This phase I trial is evaluating two drugs (RO6870810 and atezolizumab) for the treatment of advanced ovarian cancer or triple negative breast cancer

Cancer type : Multi-Cancer

Systemic therapy trial

Phase 1/2 Study Exploring the Safety, Tolerability, and Efficacy of INCAGN01876 Combined...

This phase I/II trial is evaluating a drug (INCAGN01876) in combination with two immunotherapy drugs (Ipilimumab and/or Nivolumab) to treat patients with advanced or metastatic solid tumours

Cancer type : Multi-Cancer

Systemic therapy trial

A Phase 1A/1B Multicenter, Open-label, Dose-escalation, and Dose-expansion Study to...

This phase I trial is evaluating a new biological therapy (AK-105) in patients with advanced solid cancers

Cancer type : Multi-Cancer

Systemic therapy trial

Study to Evaluate the Safety, Tolerability, Pharmacokinetics (PK) and Anti-tumor Activity...

This phase I trial is evaluating the safety of a drug (FN-1501) in patients with advanced solid tumours

Cancer type : Multi-Cancer

Systemic therapy trial

ENG8 : A Phase 1 Study of Anti-Human EGFR (Vectibix Sequence) Targeted EDVs Carrying the...

This phase I trial is using a new technology (EDV) to deliver chemotherapy (PNU-159682) and immunotherapy (EDVs40-mer) drugs in patients with advanced solid tumours

Cancer type : Multi-Cancer

Systemic therapy trial

ABBV-927 : A Multi-Center, Phase 1, Open-Label, Dose-Escalation Study of ABBV-927, an...

This phase I trial is evaluating ABBV-927 (an immunotherapy) alone and in combination with nivolumab for the treatment of advanced cancer

Cancer type : Multi-Cancer

Systemic therapy trial

AGCT1531 : A Phase 3 Study of Active Surveillance for Low Risk and a Randomized Trial of Carboplatin...

This phase III trial is evaluating how well active surveillance and four different chemotherapy drugs (bleomycin, carboplatin, etoposide, or cisplatin) work in treating paediatric or adult patients with germ cell tumours

Cancer type : Multi-Cancer

Systemic therapy trial

A Phase 1, First-in-Human, Open-label Study Evaluating the Safety, Tolerability,...

This phase I trial is trying to find the optimal dose of an oral drug (AMG 510) to treat patients with advanced cancers with a specific KRAS mutation

Cancer type : Multi-Cancer

Systemic therapy trial

HLX20 : A Phase 1 Study of HLX20, a Human Monoclonal Antibody Targeting Programmed Death Ligand 1...

This phase I trial is testing a new drug (HLX20) for people whose cancer has spread or come back following prior therapy

Cancer type : Multi-Cancer

Systemic therapy trial

MYPHISMO : First-in-human Phase I Clinical Trial of a Combined Immune Modulatory Approach Using...

This phase I trial is looking at the effects of two immunotherapies (TetMYB Vaccine in combination with BGB-A317) in patients with advanced cancers ( including colorectal and adenoid cystic cancer) that may have spread to other parts of the body

Cancer type : Multi-Cancer

Systemic therapy trial

A Phase I/Ib, Open-label, Multi-center, Study of NZV930 as a Single Agent and in...

This phase I trial is evaluating a new intravenous drug (NZV930) alone and in combination with two other drugs (one intravenous and one oral) for the treatment of specific advanced cancers

Cancer type : Multi-Cancer

Systemic therapy trial

A Phase 1, Open-label, Dose-escalation and Dose-expansion Study to Evaluate the Safety,...

This phase I trial is evaluating a new biological therapy (MEDI5752) alone and in combination with various chemotherapy / immunotherapy drugs for the treatment of advanced solid cancers

Cancer type : Multi-Cancer

Systemic therapy trial

An Open-Label, Multi-center, Dose-Escalation Phase I Study to Evaluate Safety,...

This phase I trial is testing a new drug (KN046) in patients with advanced cancers who are not able to have any other standard therapies

Cancer type : Multi-Cancer

Systemic therapy trial

MK7123-034 : A Phase II Study of Navarixin (MK-7123) in Combination With Pembrolizumab (MK-3475) in...

This phase II trial is testing the effectiveness of an oral drug (MK-7123 / Navarixin) when given in combination with an immunotherapy treatment (Pembrolizumab) in patients with non-small cell (NSC) lung cancer, castration resistant prostate cancer or microsatellite stable colorectal cancer

Cancer type : Multi-Cancer

Systemic therapy trial

MK-7684-001 : A Phase 1 Trial of MK-7684 as Monotherapy and in Combination With Pembrolizumab in...

This Phase I trial is evaluating a new biological immunotherapy drug (MK-7684) alone and in combination with another immunotherapy drug (Pembrolizumab) in patients with advanced solid tumours

Cancer type : Multi-Cancer

Systemic therapy trial

A Phase 1 Study Evaluating the Safety, Pharmacokinetics, and Anti-tumor Activity of...

This Phase I trial is evaluating an intravenous drug (ABBV-321) in patients with advanced cancers that are associated with EGFR overexpression

Cancer type : Multi-Cancer

Systemic therapy trial

Akeso : A Phase 1A/1B Multicenter, Open-label, Dose-escalation, and Dose-expansion Study to...

This phase I trial is evaluating a new biological therapy (AK-104) in adult patients with advanced solid cancers (excluding some blood cancers)

Cancer type : Multi-Cancer

Systemic therapy trial

A Multicenter, Phase 1, Open-Label, Dose-Escalation Study of ABBV-181, a Monoclonal...

This phase I trial is combining two anti-cancer therapies (ABBV-181 and Rovalpituzumab Tesirine) in patients with advanced solid tumours

Cancer type : Multi-Cancer

Systemic therapy trial

A Phase I, Open Label, Multicenter Study of the Safety and Efficacy of MIW815 (ADU-S100)...

This phase I trial is combining to drugs (PDR001 and MIW815) for the treatment of advanced solid cancers and Lymphomas

Cancer type : Multi-Cancer

Systemic therapy trial

CBT-501 : A Phase 1 Multicenter, Dose Escalation Study of CBT-501 in Subjects With Select Advanced...

This phase I trial is trying to determine how safe and effective CBT-501 is in individuals with an advanced solid cancer (excluding blood cancer) that has gotten worse or come back

Cancer type : Multi-Cancer

Systemic therapy trial

SHR-1210 : An Open-label, Multicenter, Non-randomized, Dose Escalation Phase 1 Trial to Evaluate...

This phase I trial is trying to determine the most appropriate dose of a new injection (INCSHR01210) to treat patients with advanced solid cancers (excluding blood cancers)

Cancer type : Multi-Cancer

Systemic therapy trial

CT829 : A Phase I/II Study of Safety and Efficacy of Ribociclib (LEE011) in Combination With...

This phase I/II trial is evaluating two drugs (ribociclib and trametinib) for the treatment of advanced cancers (excluding blood cancer)

Cancer type : Multi-Cancer

Systemic therapy trial

STARTRK-2 : An Open-Label, Multicenter, Global Phase 2 Basket Study of Entrectinib for the Treatment...

This phase II trial is evaluating an investigational drug (entrectinib) for the treatment of patients with solid cancers that express the NTRK1/2/3, ROS1 or ALK gene

Cancer type : Multi-Cancer

Systemic therapy trial

INDUCE-1 : A Phase I Open Label Study of GSK3359609 Administered Alone and in Combination With...

This phase I trial is evaluating a new drug (GSK3359609) administered alone and in combination with an anticancer agent (pembrolizumab) for the treatment of advanced cancer

Cancer type : Multi-Cancer

Systemic therapy trial

TIGIT : A Phase Ia/Ib Open-Label, Dose-Escalation Study of the Safety and Pharmacokinetics of...

This phase I trial is evaluating a new drug (MTIG7192A) alone and in combination with atezolizumab (an immunotherapy drug) for the treatment of advanced cancer

Cancer type : Multi-Cancer

Systemic therapy trial

PUMA : An Open-label, Multicenter, Multinational, Phase 2 Study Exploring the Efficacy and...

This phase II trial is evaluating neratinib (targeted) therapy in patients that have solid cancers with activating HER2, HER3 or EGFR mutations

Cancer type : Multi-Cancer

Systemic therapy trial

REGN2810 : A First-in-Human Study of Repeat Dosing With REGN2810, a Monoclonal, Fully Human Antibody...

This phase III trial is evaluating REGN2810, alone and in combination with other anti-cancer therapies, for the treatment of advanced cancer

Cancer type : Multi-Cancer

Systemic therapy trial

GO29313 : A PHASE I, OPEN-LABEL, DOSE-ESCALATION STUDY OF THE SAFETY AND PHARMACOKINETICS OF...

This phase I trial is assessing an intravenously (in the vein) administered drug (MOXR0916) for the treatment of locally advanced or metastatic solid cancers (excluding blood cancer)

Cancer type : Multi-Cancer

Radiotherapy trial

StereoCav : Randomised trial of adjuvant versus delayed stereotactic radiotherapy to resection cavity...

This phase II trial is comparing adjuvant radiotherapy with delayed radiotherapy in people who have previously resected cancer that has spread to the brain

Cancer type : Multi-Cancer

Systemic therapy trial

M7824 : A Phase I, Open-label, Multiple-ascending Dose Trial to Investigate the Safety,...

This phase I trial is assessing a new drug known as M7824, given to patients with a solid cancer (not blood cancer) every two weeks

Cancer type : Multi-Cancer

Systemic therapy trial

ACT001 : A phase 1 dose-escalation study to evaluate the safety, tolerability and pharmacokinetics...

This phase I trial is evaluating the study drug ACT001 in patients with advanced (solid) cancers

Cancer type : Multi-Cancer

Systemic therapy trial

Beigene 2 : A Phase IA, Open Label, Multiple Dose, Dose Escalation Study to Investigate the Safety...

This phase I trial is evaluating a new drug known as BGB-290 in patients with solid cancers

Cancer type : Multi-Cancer

Systemic therapy trial

BRF116013 : Phase I/IIa, 2-Part, Multi-Center, Single-Arm, Open-Label Study to Determine the Safety,...

This phase I trial is evaluating an oral drug (dabrafenib) for children and adolescents with advanced BRAF V600-mutation positive cancers

Cancer type : Multi-Cancer

Systemic therapy trial

LeYPh1-02 : A phase I study investigating the safety and tolerability of an infusion of T lymphocytes...

This phase I trial is assessing a new systemic therapy (LeY CAR-T cell therapy) in patients with solid cancers that express the LeY gene

Cancer type : Multi-Cancer

Systemic therapy trial

CT821 : A Phase 1 Multicenter, Open-label, Dose-escalation and Dose-expansion Study to Evaluate...

This phase I trial is evaluating two drugs (MEDI94 and MEDI4736) alone and in combination for the treatment of adult patients with select solid cancers

Cancer type : Multi-Cancer

Systemic therapy trial

A8081001 : Phase 1 Safety, Pharmacokinetic And Pharmacodynamic Study Of PF-02341066, A c-Met/HGFR...

This phase I trial is evaluating a new oral drug (PF-02341066) in patients with advanced cancer (excluding Leukaemia)

Cancer type : Multi-Cancer

Systemic therapy trial

EZ7438 : An Open-Label, Multicenter, Phase 1/2 Study of E7438 (EZH2 Histone Methyl Transferase...

This phase I/II trial is evaluating an oral drug (tazemetostat) alone and in combination with a steroid (prednisolone) for the treatment of advanced solid cancers and patients with B Cell Lymphoma

Cancer type : Multi-Cancer

Systemic therapy trial

APG-1387 : A phase 1, open label, multi-center, dose escalation study of the safety, tolerability,...

This phase I trial is evaluating an intravenously (in the vein) administered drug (APG-1387) in patients with advanced solid cancers or Lymphoma

Cancer type : Multi-Cancer

Systemic therapy trial

CT680 : A Dose-Finding Phase 1 Study of TAS-120 in Patients With Advanced Solid Tumors With or...

This phase I/II trial is evaluating an oral drug (TAS-120) in patients with an advanced solid cancer or Multiple Myeloma

Cancer type : Multi-Cancer

Systemic therapy trial

LOXO-RET-17001 : A Phase 1 Study of Oral LOXO-292 in Patients With Advanced Solid Tumors, Including...

This phase I trial is evaluating a new oral drug (LOXO-292) in patients with Non-Small Cell (NSC) Lung Cancer, Medullary Thyroid Cancer (MTC) or another type of cancer with increased RET activity

Cancer type : Multi-Cancer

Systemic therapy trial

KEYNOTE-240 : A Phase III Study of Pembrolizumab (MK-3475) vs. Best Supportive Care as...

This phase III trial is evaluating pembrolizumab in patients who have previously received systemic treatment for advanced hepatocellular (liver) cancer

Cancer type : Liver

Multiple treatment types

RTN2 : A Randomised Trial of Post-operative Radiation Therapy Following Wide Excision of...

This phase III trial is comparing surgery alone and in combination with radiation therapy for the treatment of primary melanoma that has histoglogical features of neurotropism

Cancer type : Multi-Cancer

Systemic therapy trial

CT952 : A Phase 1, Open-label, Multicenter, Dose-escalation Study of CK-301 Administered...

This phase I trial is evaluating an intravenous drug (CK-301) in patients with select advanced cancers

Cancer type : Multi-Cancer

Systemic therapy trial

IMagyn050 : A Phase III, Multicenter, Randomized, Study of Atezolizumab Versus Placebo Administered...

This phase III trial is trying to determine the effect of combining atezolizumab and three other drugs (paclitaxel, carboplatin and bevacizumab) in patients with ovarian, fallopian tube or peritoneal cancer

Cancer type : Multi-Cancer

Systemic therapy trial

EBC-46 : Phase I Dose-Escalation Study to Determine the Safety and Tolerability of an...

This phase I trial is evaluating an intratumoural injection in patients with skin cancer and cancers of the head and neck

Cancer type : Multi-Cancer

Systemic therapy trial

A Phase 1, Multicenter, Open-label, Multiple Dose-escalation Study of ARX788,...

This phase I trial is evaluating a new intravenous drug (ARX788) in patients with HER2+ advanced cancers

Cancer type : Multi-Cancer

Systemic therapy trial

The EMBRACE study : Phase II clinical trial of the PARP inhibitor, olaparib, in HR-deficient metastatic...

This Phase II trial is evaluating an oral drug (Olaparib) in the treatment of HR-deficient metastatic breast cancer and relapsed ovarian cancer without BRCA1 and BRCA2 mutations

Cancer type : Multi-Cancer

Radiotherapy trial

CORE : A Randomised Trial of Conventional Care Versus Radioablation (Stereotactic Body...

This phase II/III trial is comparing standard of care techniques for patients with Prostate, Breast or Non-Small Cell (NSC) Lung cancer, with a type of stereotactic body radiotherapy

Cancer type : Multi-Cancer

Systemic therapy trial

JAVELIN Medley : A Phase 1b/2 Open-Label Study To Evaluate Safety, Clinical Activity, Pharmacokinetics And...

This phase I/II trial is combining avelumab with other immunotherapies for the treatment of patients with advanced cancer

Cancer type : Multi-Cancer

Systemic therapy trial

NORTH : A Phase II Study of Panobinostat in Paediatric, Adolescent and Young Adult Patients with...

This phase II trial is testing the effectiveness of a new oral drug (Pabinostat) in paediatric and adult patients who have an osteosarcoma, rhabdoid tumour and/or neuroblastoma that has gotten worse or not responded to prior treatment

Cancer type : Multi-Cancer

Systemic therapy trial

Rap CV : A phase I study of vinorelbine, cyclophosphamide and Rapamycin for recurrent malignancies...

This phase I trial is evaluating chemotherapy for the treatment of children with a cancer that has come back

Cancer type : Multi-Cancer

Systemic therapy trial

CT959 : A Phase I/2a Dose Escalation and Cohort Expansion Study of the Safety, Tolerability, and...

This phase I/II trial is assessing a new experimental drug (BMS-986016) alone and in combination with Nivolumab immunotherapy in patients with select solid tumours that have spread or cannot be removed by surgery

Cancer type : Multi-Cancer

Systemic therapy trial

TRuST : Tazemetostat Rollover Study (TRuST): An Open-Label Rollover Study

This study will provide continuing availability to tazemetostat as a single agent to subjects who have completed their participation in a previous study

Cancer type : Multi-Cancer

Systemic therapy trial

KEYNOTE-158 : A Clinical Trial of Pembrolizumab (MK-3475) Evaluating Predictive Biomarkers in Subjects...

This phase II trial is testing pembrolizumab (an immunotherapy drug) in patients with advanced cancers that have not responded (or worsened) on standard treatment

Cancer type : Multi-Cancer

Systemic therapy trial

M13-833 : A Phase 1 Study of the Safety and Pharmacokinetics of Venetoclax in Pediatric and Young...

This phase I trial is evaluating an oral drug (venetoclax) with or without chemotherapy in children and young adults with relapsed or refractory malignancies

Cancer type : Multi-Cancer

Systemic therapy trial

KEYNOTE-051 : A Phase I/II Study of Pembrolizumab (MK-3475) in Children With Advanced Melanoma or a...

This phase I/II trial is evaluating pembrolizumab (an immunotherapy drug) in children with advanced Melanoma, PD-L1 positive solid cancer or Lymphoma

Cancer type : Multi-Cancer

Systemic therapy trial

IMP4297 : A Phase I, Open-label, Dose-escalation Study of the Safety and Pharmacokinetics of...

This phase I trial is evaluating a new drug (IMP4297) for the treatment of advanced cancers (excluding blood cancer)

Cancer type : Multi-Cancer

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