TOP GEAR : A randomised phase II/III trial of preoperative chemoradiotherapy versus preoperative chemotherapy for resectable gastric cancer (Other IDs: TROG 08.08, AG0407GR).

Male or<br/>FemaleGender Male or
Female

RecruitingStatus Recruiting

Multiple<Br/>Treatment TypesTypeMultiple
Treatment Types

Two/ThreePhase Two/Three

18 - 75Age 18 - 75

Stomach<br/>CancersCancer LocationStomach
Cancers

Systemic therapy,Radiotherapy,Multiple treatment types | Stomach and upper gastrointestinal tractStomach

Trial Overview Read MoreRead more

This phase II/III trial is comparing preoperative chemradiotherapy with preoperative chemotherapy for patients with resectable gastric cancer.
 

This trial is treating patients with Stomach (Gastric) and Gastro-Oesophageal Junction Cancers.

This is a systemic therapy and radiotherapy trial.

You may be able to join this trial if:

  • Your cancer has not spread to other parts of the body.
  • You have been diagnosed with cancer, but have not received any treatment.

You may be excluded from this trial if:

  • You have had certain treatments, surgical procedures or drugs.
  • You have a certain disease or psychological condition.
  • You have been diagnosed with a prior or secondary type of cancer.

Clinical trials have complex eligibility criteria - talk to your doctor about your interest in this trial.

Clinical Summary Read MoreRead more

Trial Identifiers

Use the hyperlinks, where available to access additional clinical trial information.

Scientific Title

A randomised phase II/III trial of preoperative chemoradiotherapy versus preoperative chemotherapy for resectable gastric cancer (Other IDs: TROG 08.08, AG0407GR).

Cooperative Group

Australasian Gastro-Intestinal Trials Group (AGITG)

Summary

The main treatment for stomach cancer is surgery. However, even with surgery there is still a risk that the cancer may come back if no further treatment is given. Over the last 5 years, 2 large international studies have shown that giving additional treatment with radiotherapy and chemotherapy may improve the chances of curing patients with stomach cancer. Firstly, a large British study called MAGIC has shown that giving chemotherapy BEFORE and AFTER surgery is better than just surgery alone. Secondly, a large US study called INT0116 has shown that giving combined chemotherapy and radiotherapy together (chemoradiation) AFTER surgery is better than surgery alone. The purpose of this study is to compare these 2 treatments to determine which is better. Unlike in the US study, in this study we will be giving chemoradiation BEFORE surgery (preoperative treatment), rather than AFTER surgery (postoperative treatment). This is because we know from studies in other types of cancers that preoperative treatment is better than postoperative treatment. In addition, preoperative treatment also produces fewer side effects so that patients are more likely to complete the planned treatment. The main aim of this study is therefore to determine if preoperative chemoradiation is more effective than preoperative chemotherapy alone for patients with localised stomach cancer who are going to be treated with surgery. We will also be looking at the side effects of the two treatment combinations.

Recruiting Hospitals Read MoreRead more

Peter MacCallum Cancer Centre
Moorabbin
Moorabbin Research
moorabbin.research@petermac.org
03 9928 8994

Peter MacCallum Cancer Centre, Radiation Oncology
East Melbourne
Ms Jenny Trinh
Jenny.Trinh@petermac.org
03 9656 3626

St Vincent's Hospital, Medical and Radiation Oncology
Fitzroy
Ms Nadia Ranieri
oncology.research@svha.org.au
03 9288 3167

Western Health - Sunshine Hospital
St Albans
Ms Heike Raunow
Heike Raunow@wh.org.au
03 8395 9167

Not Recruiting Hospitals Read MoreRead more

Closed

Austin Hospital
Heidelberg
Ms Samantha Chakar
samantha.chakar@austin.org.au
03 9496 3088

Barwon Health, University Hospital Geelong
Geelong
Dr Lea-Anne Harrison
leaanne.harrison@barwonhealth.org.au
03 42 15 2758