TIGIT: This phase I trial is evaluating a new drug (MTIG7192A) alone and in combination with atezolizumab (an immunotherapy drug) for the treatment of advanced cancerA Phase Ia/Ib Open-Label, Dose-Escalation Study of the Safety and Pharmacokinetics of MTIG7192A as a Single Agent and in Combination With Atezolizumab in Patients With Locally Advanced or Metastatic Tumors

Exclusion

• Any anti-cancer therapy, whether investigational or approved, including chemotherapy, hormonal therapy, or radiotherapy, within 3 weeks prior to initiation of study treatment
• Malignancies other than disease under study within 5 years prior to Day 1 of Cycle 1
• Primary central nervous system (CNS) malignancy, or untreated/active CNS metastases
• Leptomeningeal disease
• History of idiopathic pulmonary fibrosis, pneumonitis, organizing pneumonia, or evidence of active pneumonitis on Screening chest computed tomograph (CT) scan
• History of autoimmune disease
• Positive human immunodeficiency virus (HIV) test
• Active hepatitis B or C, or tuberculosis
• Severe infection within 4 weeks prior to randomization
• Prior allogeneic bone marrow or solid organ transplant
• Significant cardiovascular disease
• Known clinically significant liver disease